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Among these, some clinical and pathological BCC variants pose a higher risk due to their more aggressive biological behavior. Morpheaform BCC (morBCC), also known as sclerosing, fibrosing, or morpheic BCC, represents up to 5\u201310% of all BCC. Overall, morBCC carries a poorer prognosis due to late presentation, local tissue destruction, tumor recurrence, and higher frequency of metastasis. In this systematic review, we review the epidemiological, clinical, morphological, dermatoscopical, and molecular features of morBCC. After the title and abstract screening of 222 studies and the full-text review of 84 studies, a total of 54 studies met the inclusion criteria and were thus included in this review.<\/jats:p>","DOI":"10.3390\/curroncol30110720","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:04:32Z","timestamp":1699959872000},"page":"9906-9928","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-5738","authenticated-orcid":false,"given":"Santina","family":"Conte","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ghezelbash","sequence":"additional","affiliation":[{"name":"Cancer Axis, Lady Davis Institute for Medical Research, Montreal, QC H3T 1E2, Canada"},{"name":"Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonika","family":"Nallanathan","sequence":"additional","affiliation":[{"name":"Cancer Axis, Lady Davis Institute for Medical Research, Montreal, QC H3T 1E2, Canada"},{"name":"Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-7956","authenticated-orcid":false,"given":"Philippe","family":"Lefran\u00e7ois","sequence":"additional","affiliation":[{"name":"Cancer Axis, Lady Davis Institute for Medical Research, Montreal, QC H3T 1E2, Canada"},{"name":"Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada"},{"name":"Division of Dermatology, Department of Medicine, McGill University, Montreal, QC H3G 2M1, Canada"},{"name":"Division of Dermatology, Department of Medicine, Jewish General Hospital, Montreal, QC H3T 1E2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Camela, E., Ilut Anca, P., Lallas, K., Papageorgiou, C., Manoli, S.M., Gkentsidi, T., Eftychidou, P., Liopyris, K., Sgouros, D., and Apalla, Z. 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