{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:16:44Z","timestamp":1772583404543,"version":"3.50.1"},"reference-count":17,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-127"],"award-info":[{"award-number":["2022-PUMCH-B-127"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-A-036"],"award-info":[{"award-number":["2022-PUMCH-A-036"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022YFC2402305"],"award-info":[{"award-number":["2022YFC2402305"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022YFC2407101"],"award-info":[{"award-number":["2022YFC2407101"]}]},{"name":"National Key R&amp;D Program of China, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2022-PUMCH-B-127"],"award-info":[{"award-number":["2022-PUMCH-B-127"]}]},{"name":"National Key R&amp;D Program of China, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2022-PUMCH-A-036"],"award-info":[{"award-number":["2022-PUMCH-A-036"]}]},{"name":"National Key R&amp;D Program of China, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2022YFC2402305"],"award-info":[{"award-number":["2022YFC2402305"]}]},{"name":"National Key R&amp;D Program of China, Ministry of Science and Technology of the People\u2019s Republic of China","award":["2022YFC2407101"],"award-info":[{"award-number":["2022YFC2407101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Nodal failure is a major failure pattern for patients with FIGO IIIC cervical cancer, which is further associated with worse survival. This study was designed to investigate risk factors for nodal failure in FIGO IIIC cervical cancer patients. Methods: The characteristics of positive lymph nodes (LNs) and relevant clinical factors of 162 FIGO IIIC cervical cancer patients were collected. The chi-square test and logistic regression model were used to identify risk factors for nodal failure. Results: In total, 368 positive LNs were identified, including 307 pelvic LNs and 61 para-aortic LNs. The nodal failure rates for all LNs, pelvic LNs, and para-aortic LNs were 9.2%, 7.8%, and 16.4%, respectively. After 20 fractions of RT, a nodal short diameter (D20F) \u2265 0.95 cm and a ratio of nodal shrinkage (\u0394V20F) &lt; 0.435 resulted; &lt;4 cycles of chemotherapy indicated higher nodal failure rates for all LNs. For pelvic LNs, \u0394V20F &lt; 0.435 and &lt;4 cycles of chemotherapy were associated with a higher incidence of nodal failure. For para-aortic LNs, \u0394V20F &lt; 0.435 was the only risk factor for nodal failure. Conclusions: Para-aortic LNs were more likely to experience nodal failure than pelvic LNs. Nodal shrinkage during radiotherapy and cycles of chemotherapy were associated with nodal failure in patients with FIGO IIIC cervical cancer.<\/jats:p>","DOI":"10.3390\/curroncol30120756","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T05:47:30Z","timestamp":1702014450000},"page":"10385-10395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors for Nodal Failure in Patients with FIGO IIIC Cervical Cancer Receiving Definitive Image-Guided Radiotherapy"],"prefix":"10.3390","volume":"30","author":[{"given":"Xiaoliang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-2320","authenticated-orcid":false,"given":"Fuquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1002\/1097-0142(19910601)67:11<2776::AID-CNCR2820671111>3.0.CO;2-L","article-title":"Carcinoma of the cervix treated with radiation therapy. 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