{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:43:59Z","timestamp":1790963039175,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Men with localized invasive penile cancer (PC) can be treated with organ-sparing treatments with different functional and aesthetical outcomes. Thus, the aim of this study is to investigate sexual outcomes in patients with PC confined to the glans that underwent wide local excision (WLE) vs. glansectomy with urethral glanduloplasty. Methods: Complete data from 60 patients with PC were analyzed at our institution from 2017 to 2022. Patients were asked for personal habits and clinical features. PC was assessed with a clinical visit and imaging techniques. At the outpatient follow-up visit or phone call, all patients compiled the Changes in Sexual Function Questionnaire (CSFQ) and the International Index of Erectile Function in its short 5-item form (IIEF-5). Erectile function (EF) impairment was categorized using Cappelleri\u2019s criteria. Results: Overall, 34 patients with PC confined to the glans (c \u2264 T2N0) were included. Of those, 12 underwent WLE and 22 underwent glansectomy with urethral glanduloplasty. Using multivariable logistic regression, glansectomy (OR: 3.49) and diabetes (OR: 2.33) were associated with erectile disfunction (IEEF &lt; 22). Meanwhile, using multivariable linear regression analysis, younger patients (Coeff: \u22122.41) and those that underwent glansectomy (Coeff: \u22127.5) had a higher risk of sexual function impairment, according to the CSFQ. Conclusions: Patients with PC \u2264 T2N0 that underwent WLE have better outcomes in terms of sexual functioning than the patients who underwent glansectomy and uretheral gladuloplasty. Further research is needed to clarify the outcomes of penile-sparing surgery, to inform patients in pre-surgical counseling more comprehensively, and to meet their post-operative expectations more effectively.<\/jats:p>","DOI":"10.3390\/curroncol30120765","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T12:57:56Z","timestamp":1702904276000},"page":"10501-10508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sexual Outcomes after Conservative Management for Patients with Localized Penile Cancer"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8431-9830","authenticated-orcid":false,"given":"Simone","family":"Cilio","sequence":"first","affiliation":[{"name":"Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Tufano","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, Policlinico Umberto I Hospital, \u201cSapienza\u201d Rome University, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Pezone","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Alvino","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-9315","authenticated-orcid":false,"given":"Gianluca","family":"Spena","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savio Domenico","family":"Pandolfo","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Del Prete","sequence":"additional","affiliation":[{"name":"Scientific Directorate, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, Via M. Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Amato","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Damiano","sequence":"additional","affiliation":[{"name":"Urology Unit, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salonia","sequence":"additional","affiliation":[{"name":"Unit of Urology\/Division of Experimental Oncology, URI, IRCCS Ospedale San Raffaele, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7045-7725","authenticated-orcid":false,"given":"Riccardo","family":"Autorino","sequence":"additional","affiliation":[{"name":"Department of Urology, Rush University Medical Center, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Izzo","sequence":"additional","affiliation":[{"name":"Uro-Gynecological Department, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, Via M. Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Passaro","sequence":"additional","affiliation":[{"name":"Urology Unit, Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisto","family":"Perdon\u00e0","sequence":"additional","affiliation":[{"name":"Uro-Gynecological Department, Istituto Nazionale Tumori di Napoli, IRCCS \u201cG. Pascale\u201d, Via M. Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.eururo.2023.02.027","article-title":"European Association of Urology-American Society of Clinical Oncology Collaborative Guideline on Penile Cancer: 2023 Update","volume":"83","author":"Brouwer","year":"2023","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41443-022-00557-5","article-title":"Analysis of quality information provided by \u201cDr. YouTubeTM\u201d on Phimosis","volume":"35","author":"Cilio","year":"2023","journal-title":"Int. J. Impot. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Guimaraes, M.J., Macieira, R., Azevedo, F., and Lisboa, C. (2023). Association between HPV infection and penile cancer and penile intraepithelial neoplasia: A retrospective observational study. J. Eur. Acad. Dermatol. Venereol. JEADV, 1\u20135.","DOI":"10.1111\/jdv.19393"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Borque-Fernando, \u00c1., Gaya, J.M., Esteban-Esca\u00f1o, L.M., G\u00f3mez-Rivas, J., Garc\u00eda-Baquero, R., Agreda-Casta\u00f1eda, F., Gallioli, A., Verri, P., Ortiz-Vico, F.J., and Amir-Nicolau, B.F. (2023). Epidemiology, Diagnosis and Management of Penile Cancer: Results from the Spanish National Registry of Penile Cancer. Cancers, 15.","DOI":"10.3390\/cancers15030616"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Flammia, R.S., Tufano, A., Antonelli, L., Bernardotto, A., Castro Bigalli, A.A., Tian, Z., Smaldone, M.C., Karakiewicz, P.I., Panebianco, V., and Leonardo, C. (2021). Diagnostic Performance of Magnetic Resonance Imaging for Preoperative Local Staging of Penile Cancer: A Systematic Review and Meta-Analysis. Appl. Sci., 11.","DOI":"10.3390\/app11157090"},{"key":"ref_6","first-page":"1010","article-title":"French AFU Cancer Committee Guidelines-Update 2022\u20132024: Penile cancer","volume":"32","author":"Savoie","year":"2022","journal-title":"Prog. En Urol. J. De L\u2019association Fr. D\u2019urologie De La Soc. Fr. D\u2019urologie"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.urolonc.2021.01.012","article-title":"Update on organ preserving surgical strategies for penile cancer","volume":"40","author":"Emmanuel","year":"2022","journal-title":"Urol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Maddineni, S.B., Lau, M.M., and Sangar, V.K. (2009). Identifying the needs of penile cancer sufferers: A systematic review of the quality of life, psychosexual and psychosocial literature in penile cancer. BMC Urol., 9.","DOI":"10.1186\/1471-2490-9-8"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12262-016-1543-5","article-title":"Sexuality in Surgically Treated Carcinoma Penis Patients and Their Partners","volume":"80","author":"Bhat","year":"2018","journal-title":"Indian J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/MOU.0000000000000711","article-title":"Localized disease: Types of reconstruction\/plastic surgery techniques after glans resurfacing\/glansectomy\/partial\/total penectomy","volume":"30","author":"Alnajjar","year":"2020","journal-title":"Curr. Opin. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.urology.2020.03.058","article-title":"Oncological and Functional Outcomes After Organ-Sparing Plastic Reconstructive Surgery for Penile Cancer","volume":"142","author":"Chavarriaga","year":"2020","journal-title":"Urology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction","volume":"11","author":"Rosen","year":"1999","journal-title":"Int. J. Impot. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/00926230500232909","article-title":"Clayton. Reliability and Construct Validity of the Changes in Sexual Functioning Questionnaire Short-Form (CSFQ-14)","volume":"32","author":"Keller","year":"2006","journal-title":"J. Sex Marital. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.eururo.2010.01.039","article-title":"EAU penile cancer guidelines 2009","volume":"57","author":"Pizzocaro","year":"2010","journal-title":"Eur. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/(SICI)1097-0142(19990401)85:7<1565::AID-CNCR18>3.0.CO;2-0","article-title":"Squamous cell carcinoma of the penis and microscopic pathologic margins: How much margin is needed for local cure?","volume":"85","author":"Hoffman","year":"1999","journal-title":"Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.juro.2017.01.088","article-title":"Organ Sparing Surgery for Penile Cancer: A Systematic Review","volume":"198","author":"Kamel","year":"2017","journal-title":"J. Urol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.urology.2011.08.006","article-title":"Organ-sparing surgery for penile cancer: Complications and outcomes","volume":"78","author":"Li","year":"2011","journal-title":"Urology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ejso.2018.03.021","article-title":"A Comparative study of two types of organ-sparing surgeries for early stage penile cancer: Wide local excision vs partial penectomy","volume":"44","author":"Wan","year":"2018","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/1008-682X.168690","article-title":"Sexual outcomes after partial penectomy for penile cancer: Results from a multi-institutional study","volume":"19","author":"Sansalone","year":"2017","journal-title":"Asian J. Androl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/sm2.56","article-title":"Outcomes for Organ-Preserving Surgery for Penile Cancer","volume":"3","author":"Scarberry","year":"2015","journal-title":"Sex. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"E423","DOI":"10.5489\/cuaj.2801","article-title":"Sexual function after surgical treatment for penile cancer: Which organ-sparing approach gives the best results?","volume":"9","author":"Sedigh","year":"2015","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/j.clgc.2018.09.018","article-title":"Development of a Novel Prognostic Risk Score for Predicting Complications of Penectomy in the Surgical Management of Penile Cancer","volume":"17","author":"Velazquez","year":"2019","journal-title":"Clin. Genitourin. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"329.e11","DOI":"10.1016\/j.urolonc.2023.03.017","article-title":"Penile cancer in younger men-A more aggressive disease?","volume":"41","author":"Browne","year":"2023","journal-title":"Urol. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/12\/765\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:40:25Z","timestamp":1760132425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/30\/12\/765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,17]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["curroncol30120765"],"URL":"https:\/\/doi.org\/10.3390\/curroncol30120765","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,17]]}}}