{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:46:42Z","timestamp":1792118802321,"version":"4.4.0"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Resection of additional tissue circumferentially around the cavity left by lumpectomy (cavity shave) was suggested to reduce rates of positive margins and re-excision. Methods: A single center retrospective study which analyzed margins status, re-excision, and surgical time in patients who underwent breast conserving surgery and cavity shave or intraoperative evaluation of resection margins. Results: Between 2021 and 2023, 594 patients were enrolled in the study. In patients subjected to cavity shave, a significant reduction in positive, focally positive, or closer margins was reported 8.9% vs. 18.5% (p = 0.003). No difference was reported in terms of surgical re-excision (p &lt; 0.846) (5% vs. 5.5%). Surgical time was lower in patients subjected to cavity shave (&lt;0.001). The multivariate analysis intraoperative evaluation of sentinel lymph node OR 1.816 and cavity shave OR 2.909 were predictive factors for a shorter surgical time. Excluding patients subjected to intraoperative evaluation of sentinel lymph node and patients with ductal carcinoma in situ, patients that underwent the cavity shave presented a reduced surgical time (67.9 + 3.8 min vs. 81.6 + 2.8 min) (p = 0.006). Conclusions: Cavity shaving after lumpectomy reduced the rate of positive margins and it was associated with a significant reduction in surgical time compared to intraoperative evaluation of resection margins.<\/jats:p>","DOI":"10.3390\/curroncol31010035","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:56:59Z","timestamp":1705381019000},"page":"511-520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cavity Shave Margins in Breast Conservative Surgery a Strategy to Reduce Positive Margins and Surgical Time"],"prefix":"10.3390","volume":"31","author":[{"given":"Gianluca","family":"Vanni","sequence":"first","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pellicciaro","sequence":"additional","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"},{"name":"PhD Program in Applied Medical-Surgical Sciences, Department of Surgical Science, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Renelli","sequence":"additional","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Materazzo","sequence":"additional","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"},{"name":"PhD Program in Applied Medical-Surgical Sciences, Department of Surgical Science, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Sadri","sequence":"additional","affiliation":[{"name":"Plastic Surgery, Great Ormond Hospital for Children NHS Foundation Trust, London WC1N3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Enrica","family":"Marsella","sequence":"additional","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Tacconi","sequence":"additional","affiliation":[{"name":"Unit of Thoracic Surgery, Department of Surgical Sciences, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano Angelo","family":"Bastone","sequence":"additional","affiliation":[{"name":"PhD Program in Applied Medical-Surgical Sciences, Department of Surgical Science, Tor Vergata University, 00133 Rome, Italy"},{"name":"Unit of Thoracic Surgery, Department of Surgical Sciences, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8671-0609","authenticated-orcid":false,"given":"Benedetto","family":"Longo","sequence":"additional","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6067-277X","authenticated-orcid":false,"given":"Giordana","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Department of Human Pathology \u201cG. Barresi\u201d, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Cervelli","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery at Department of Surgical Science, Tor Vergata University, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-9148","authenticated-orcid":false,"given":"Massimiliano","family":"Berretta","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oreste Claudio","family":"Buonomo","sequence":"additional","affiliation":[{"name":"Breast Unit Policlinico Tor Vergata, Department of Surgical Science, Tor Vergata University, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","unstructured":"(2023, December 19). National Comprehensive Cancer Network Guidelines Version 2.2017 Invasive Breast Cancer: Margin Status in Infiltrating Carcinoma. Available online: http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/breast.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1200\/JCO.2014.55.1572","article-title":"Margins for breast-conserving surgery with whole-breast irradiation in stage I and II invasive breast cancer: American Society of Clinical Oncology endorsement of the Society of Surgical Oncology\/American Society for Radiation Oncology consensus guideline","volume":"32","author":"Buchholz","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1200\/JCO.2016.68.3573","article-title":"Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery with Whole-Breast Irradiation in Ductal Carcinoma In Situ","volume":"34","author":"Morrow","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/canjclin.52.5.277","article-title":"Standard for breast conservation therapy in the management of invasive breast carcinoma","volume":"52","author":"Morrow","year":"2002","journal-title":"CA Cancer J. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1016\/j.ejca.2010.07.043","article-title":"Meta-analysis of the impact of surgical margins on local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy","volume":"46","author":"Houssami","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/jamasurg.2014.926","article-title":"Repeat surgery after breast conservation for the treatment of stage 0 to II breast carcinoma: A report from the National Cancer Data Base, 2004\u20132010","volume":"149","author":"Wilke","year":"2014","journal-title":"JAMA Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1504473","article-title":"A Randomized, Controlled Trial of Cavity Shave Margins in Breast Cancer","volume":"373","author":"Chagpar","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1524-4741.2008.00649.x","article-title":"Effect of cavity shaving on reoperation rate following breast-conserving surgery","volume":"14","author":"Marudanayagam","year":"2008","journal-title":"Breast J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1097\/01.pas.0000180448.08203.70","article-title":"Separate cavity margin sampling at the time of initial breast lumpectomy significantly reduces the need for reexcisions","volume":"29","author":"Cao","year":"2005","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.amjsurg.2006.06.021","article-title":"The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery","volume":"192","author":"Huston","year":"2006","journal-title":"Am. J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1245\/s10434-018-6604-5","article-title":"Basic Oncoplastic Surgery for Breast Conservation: Tips and Techniques","volume":"25","author":"Kopkash","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.6004\/jnccn.2022.0030","article-title":"Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology","volume":"20","author":"Gradishar","year":"2022","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1056\/NEJMc1511344","article-title":"Cavity Shave Margins in Breast Cancer","volume":"373","author":"Bartelink","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1245\/s10434-010-1420-6","article-title":"Impact of routine cavity shave margins on breast cancer re-excision rates","volume":"18","author":"Kobbermann","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/00031348211030464","article-title":"The Effect of Lumpectomy and Cavity Shave Margin Status on Recurrence and Survival in Breast-Conserving Surgery","volume":"89","author":"Abdelsattar","year":"2023","journal-title":"Am. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clbc.2016.02.002","article-title":"Importance of Surgical Margin Status in Ductal Carcinoma In Situ","volume":"16","author":"Shaikh","year":"2016","journal-title":"Clin. Breast Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.breast.2023.08.003","article-title":"Effect of high-dose radiation therapy on positive margins after breast-conserving surgery for invasive breast cancer","volume":"71","author":"Kim","year":"2023","journal-title":"Breast"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.21873\/anticanres.16305","article-title":"Surgical Treatments for Ductal Carcinoma In Situ (DCIS) in Elderly Patients","volume":"43","author":"Buonomo","year":"2023","journal-title":"Anticancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.21873\/invivo.11884","article-title":"Does Age Matter? Estimating Risks of Locoregional Recurrence after Breast-conservative Surgery","volume":"34","author":"Vanni","year":"2020","journal-title":"In Vivo"},{"key":"ref_21","first-page":"e31","article-title":"The Effect of Intraoperative Margin Assessment During Breast Conserving Surgery for Breast Cancer in a Dutch Cohort","volume":"12","author":"Wooldrik","year":"2023","journal-title":"Clin. Breast Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1148\/rg.345130049","article-title":"Molecular classification of infiltrating breast cancer: Toward personalized therapy","volume":"34","author":"Trop","year":"2014","journal-title":"Radiographics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.suronc.2020.11.003","article-title":"Do we need to routinely perform cavity shaving with breast-conserving surgery for breast cancer? A systematic review and meta-analysis","volume":"36","author":"Mohamedahmed","year":"2021","journal-title":"Surg. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101521","DOI":"10.1016\/j.suronc.2021.101521","article-title":"Routine cavity shaves following breast conserving surgery; friend or foe?","volume":"37","author":"Monib","year":"2021","journal-title":"Surg. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jamcollsurg.2020.11.019","article-title":"Impact of Cavity Shave Margins on Margin Status in Patients with Pure Ductal Carcinoma In Situ","volume":"232","author":"Dupont","year":"2021","journal-title":"J. Am. Coll. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/SLA.0000000000003449","article-title":"Resection of Cavity Shave Margins in Stage 0-III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial","volume":"273","author":"ADupont","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1245\/s10434-017-5927-y","article-title":"A Validated Nomogram to Predict Upstaging of Ductal Carcinoma In Situ to Invasive Disease","volume":"24","author":"Jakub","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(07)61232-X","article-title":"MRI for diagnosis of pure ductal carcinoma in situ: A prospective observational study","volume":"370","author":"Kuhl","year":"2007","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1524-4741.2007.00513.x","article-title":"BI-RADS MRI enhancement characteristics of ductal carcinoma in situ","volume":"13","author":"Rosen","year":"2007","journal-title":"Breast J."},{"key":"ref_30","first-page":"2656","article-title":"Awake breast surgery and de-escalation treatment: Strategies for frail and elderly breast cancer patients","volume":"10","author":"Vanni","year":"2023","journal-title":"World Cancer Res. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12962-023-00477-1","article-title":"Cost minimization in breast conserving surgery: A comparative study of radiofrequency spectroscopy and full cavity shave margins","volume":"21","author":"Gilmore","year":"2023","journal-title":"Cost. Eff. Resour. Alloc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9271","DOI":"10.3390\/curroncol29120726","article-title":"Association of Surgical Margin Status with Oncologic Outcome in Patients Treated with Breast-Conserving Surgery","volume":"29","author":"Chae","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3747\/co.23.2989","article-title":"Reoperation costs in attempted breast-conserving surgery: A decision analysis","volume":"23","author":"Pataky","year":"2016","journal-title":"Curr. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/1\/35\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:47:37Z","timestamp":1760104057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/1\/35"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["curroncol31010035"],"URL":"https:\/\/doi.org\/10.3390\/curroncol31010035","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}