{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:39:57Z","timestamp":1791578397159,"version":"4.3.4"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Contrast-enhanced ultrasound (CEUS) is a diagnostic tool that is gaining popularity for its ability to improve overall diagnostic accuracy in bladder cancer (BC) staging. Our aim is to determine the cumulative diagnostic performance of CEUS in predicting preoperative muscle invasiveness using a comprehensive systematic review and pooled meta-analysis. Methods: A systematic review until October 2023 was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Patients with BC suspicion were offered CEUS before the transurethral resection of the bladder tumor (TURBT). The diagnostic performance of CEUS was evaluated based on non-muscle-invasive bladder cancer (NMIBC) vs. muscle-invasive bladder cancer (MIBC) confirmed at the final histopathological examination after TURBT. The outcomes were determined through pooled sensitivity, specificity, pooled positive likelihood ratio (PLR+), negative likelihood ratio (PLR\u2212), and area under the summary receiver operating characteristic (SROC) along with their respective 95% confidence intervals (CI). Results: Overall, five studies were included. In these studies, a total of 362 patients underwent CEUS prior to TURBT. The pooled sensitivity and specificity were 0.88 (95% CI: 0.81\u20130.93) and 0.88 (95% CI: 0.82\u20130.92), respectively. SROC curve depicted a diagnostic accuracy of 0.94 (95% CI: 0.81\u20130.98). The pooled PLR+ and PLR\u2212 were 7.3 (95% CI: 4.8\u201311.2) and 0.14 (95% CI: 0.08\u20130.23), respectively. Conclusions: Our meta-analysis indicates that CEUS is highly accurate in the diagnosis and staging for BC. Beyond its accuracy, CEUS offers the advantage of being a cost-effective, safe, and versatile imaging tool.<\/jats:p>","DOI":"10.3390\/curroncol31020060","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T11:25:55Z","timestamp":1706786755000},"page":"818-827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic Accuracy of Contrast-Enhanced Ultrasound (CEUS) in the Detection of Muscle-Invasive Bladder Cancer: A Systematic Review and Diagnostic Meta-Analysis"],"prefix":"10.3390","volume":"31","author":[{"given":"Antonio","family":"Tufano","sequence":"first","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Rosati","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Moriconi","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Santarelli","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-7982","authenticated-orcid":false,"given":"Vittorio","family":"Canale","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4873-3257","authenticated-orcid":false,"given":"Stefano","family":"Salciccia","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7899-8056","authenticated-orcid":false,"given":"Alessandro","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Cantisani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oncology and Pathology, University La Sapienza of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2321-0548","authenticated-orcid":false,"given":"Giovanni Battista","family":"Di Pierro","sequence":"additional","affiliation":[{"name":"Department of Maternal-Infant and Urological Sciences, \u201cSapienza\u201d Rome University, Policlinico Umberto I Hospital, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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