{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:52:05Z","timestamp":1776865925884,"version":"3.51.2"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Patients with cancer and diabetes face unique challenges. Limited data are available on diabetes management in patients undergoing concurrent chemoradiotherapy (CCRT), a curative intent anticancer therapy commonly associated with glucocorticoid administration, weight fluctuations and enteral feeds. This retrospective case\u2013control study examined the real-world incidence of acute diabetes-related complications in patients with head and neck cancer receiving CCRT, along with the impact of diabetes on CCRT tolerance and outcomes. Methods: Consecutive patients with head and neck squamous cell or nasopharyngeal cancer who underwent definitive or adjuvant CCRT between 2010 and 2019 at two large cancer centers in Australia were included. Clinicopathological characteristics, treatment complications and outcomes were collected from medical records. Results: Of 282 patients who received CCRT, 29 (10.3%) had pre-existing type 2 diabetes. None had type 1 diabetes. The majority (74.5%) required enteral feeding. A higher proportion of patients with diabetes required admission to a high-dependency or intensive care unit (17.2 versus 4.0%, p = 0.003). This difference was driven by the group who required insulin at baseline (n = 5), of which four (80.0%) were admitted to a high-dependency unit with diabetes-related complications, and three (60.0%) required omission of at least one cycle of chemotherapy. Conclusions: Patients with diabetes requiring insulin have a high risk of acute life-threatening diabetes-related complications while receiving CCRT. We recommend multidisciplinary management involving a diabetes specialist, educator, dietitian, and pharmacist, in collaboration with the cancer care team, to better avoid these complications.<\/jats:p>","DOI":"10.3390\/curroncol31020061","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T11:25:55Z","timestamp":1706786755000},"page":"828-838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acute Diabetes-Related Complications in Patients Receiving Chemoradiotherapy for Head and Neck Cancer"],"prefix":"10.3390","volume":"31","author":[{"given":"Rhiannon","family":"Mellor","sequence":"first","affiliation":[{"name":"Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M.","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, NSW 2145, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"The Kinghorn Cancer Centre, St Vincent\u2019s Hospital, Darlinghurst, NSW 2010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charley","family":"Chen","sequence":"additional","affiliation":[{"name":"Blacktown Cancer and Haematology Centre, Blacktown Hospital, Blacktown, NSW 2148, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Cuan","sequence":"additional","affiliation":[{"name":"Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvind","family":"Gambhir","sequence":"additional","affiliation":[{"name":"Blacktown Cancer and Haematology Centre, Blacktown Hospital, Blacktown, NSW 2148, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3527-0207","authenticated-orcid":false,"given":"Lakmalie","family":"Perera","sequence":"additional","affiliation":[{"name":"Nepean Cancer Care Centre, Nepean Hospital, Kingswood, NSW 2747, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Veness","sequence":"additional","affiliation":[{"name":"Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW 2145, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW 2050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purnima","family":"Sundaresan","sequence":"additional","affiliation":[{"name":"Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW 2145, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW 2050, Australia"},{"name":"Blacktown Cancer and Haematology Centre, Blacktown Hospital, Blacktown, NSW 2148, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-6603","authenticated-orcid":false,"given":"Bo","family":"Gao","sequence":"additional","affiliation":[{"name":"Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW 2145, Australia"},{"name":"Faculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW 2050, Australia"},{"name":"Blacktown Cancer and Haematology Centre, Blacktown Hospital, Blacktown, NSW 2148, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"ref_1","unstructured":"Global Burden of Disease Collaborative Network (2021). Global Burden of Disease Study 2019 (GBD 2019), Institute for Health Metrics and Evaluation (IHME)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1001\/archinternmed.2009.21","article-title":"Lifestyle risk factors and new-onset diabetes mellitus in older adults: The cardiovascular health study","volume":"169","author":"Mozaffarian","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/annonc\/mdq763","article-title":"Today\u2019s lifestyles, tomorrow\u2019s cancers: Trends in lifestyle risk factors for cancer in low- and middle-income countries","volume":"22","author":"McCormack","year":"2011","journal-title":"Ann. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/ijc.31365","article-title":"Diabetes in midlife and risk of cancer in late life: A nationwide Swedish twin study","volume":"143","author":"Bao","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Shahid, R.K., Ahmed, S., Le, D., and Yadav, S. (2021). Diabetes and Cancer: Risk, Challenges, Management and Outcomes. Cancers, 13.","DOI":"10.3390\/cancers13225735"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1001\/jama.2008.824","article-title":"Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis","volume":"300","author":"Barone","year":"2008","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2337\/dc09-1721","article-title":"Postoperative mortality in cancer patients with preexisting diabetes: Systematic review and meta-analysis","volume":"33","author":"Barone","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0300-483X(82)90009-9","article-title":"Glucose intolerance following cisplatin treatments in rats","volume":"24","author":"Goldstein","year":"1982","journal-title":"Toxicology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0041-008X(83)90266-1","article-title":"The effects of cisplatin and other divalent platinum compounds on glucose metabolism and pancreatic endocrine function","volume":"69","author":"Goldstein","year":"1983","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00726-015-2159-y","article-title":"Mass spectrometric studies on the interaction of cisplatin and insulin","volume":"48","author":"Li","year":"2016","journal-title":"Amino Acids"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4158\/EP08331.RAR","article-title":"Glucocorticoid-Induced Hyperglycemia","volume":"15","author":"Clore","year":"2009","journal-title":"Endocr. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E196","DOI":"10.1016\/j.clnesp.2015.03.045","article-title":"Enteral nutrition in head and neck cancer patients treated with intensity-modulated radiotherapy at a United Kingdom cancer centre","volume":"10","author":"Lewis","year":"2015","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1982","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/0194599815607852","article-title":"Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Surgery","volume":"154","author":"Raikundalia","year":"2016","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jcma.2018.05.008","article-title":"Hyperglycemia crisis in head and neck cancer patients with platinum-based chemotherapy","volume":"81","author":"Huang","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1038\/s41598-020-64844-1","article-title":"Impact of Diabetes Mellitus on Head and neck cancer patients undergoing concurrent chemoradiotherapy","volume":"10","author":"Kuo","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1245\/s10434-010-0996-1","article-title":"Impact of diabetes mellitus on the prognosis of patients with oral squamous cell carcinoma: A retrospective cohort study","volume":"17","author":"Wu","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"FSO683","DOI":"10.2144\/fsoa-2020-0150","article-title":"Survival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus","volume":"7","author":"Ederaine","year":"2021","journal-title":"Future Sci. OA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11795549221084832","DOI":"10.1177\/11795549221084832","article-title":"Body Mass Index and Diabetes Mellitus May Predict Poorer Overall Survival of Oral Squamous Cell Carcinoma Patients: A Retrospective Cohort from a Tertiary-Care Centre of a Resource-Limited Country","volume":"16","author":"Adnan","year":"2022","journal-title":"Clin. Med. Insights Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/hed.20737","article-title":"Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy","volume":"30","author":"Capuano","year":"2009","journal-title":"Head Neck"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/bjc.2013.458","article-title":"Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy","volume":"109","author":"Langius","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00520-011-1146-4","article-title":"Nutritional surveillance and weight loss in head and neck cancer patients","volume":"20","author":"Ehrsson","year":"2012","journal-title":"Support. Care Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13046-020-01715-7","article-title":"Oral mucositis: The hidden side of cancer therapy","volume":"39","author":"Pulito","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.radonc.2009.05.016","article-title":"Impact of the prophylactic gastrostomy for unresectable squamous cell head and neck carcinomas treated with radio-chemotherapy on quality of life: Prospective randomized trial","volume":"93","author":"Salas","year":"2009","journal-title":"Radiother. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hed.21700","article-title":"Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: A randomized study","volume":"34","author":"Silander","year":"2012","journal-title":"Head Neck"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clnu.2019.04.022","article-title":"ESPEN guideline on home enteral nutrition","volume":"39","author":"Bischoff","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_27","unstructured":"(2021). Society of Hospital Pharmacists of Australia (SHPA) Australian Don\u2019t Rush to Crush Handbook, The Society of Hospital Pharmacists of Australia. [4th ed.]."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/dme.13678","article-title":"Glycaemic management during the inpatient enteral feeding of people with stroke and diabetes","volume":"35","author":"Roberts","year":"2018","journal-title":"Diabet. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.2337\/dc12-2543","article-title":"Estimating the population prevalence of diagnosed and undiagnosed diabetes","volume":"36","author":"Leong","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/0115426504019002129","article-title":"Management of Blood Glucose and Diabetes in the Critically Ill Patient Receiving Enteral Feeding","volume":"19","author":"Charney","year":"2004","journal-title":"Nutr. Clin. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1210\/jcem.87.3.8341","article-title":"Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes","volume":"87","author":"Umpierrez","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/0284186X.2021.2022198","article-title":"Swallowing sparing intensity modulated radiotherapy versus standard parotid sparing intensity-modulated radiotherapy for treatment of head and neck cancer: A randomized clinical trial","volume":"61","author":"Ashour","year":"2022","journal-title":"Acta Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1470-2045(23)00265-6","article-title":"Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): A phase 3, multicentre, randomised, controlled trial","volume":"24","author":"Nutting","year":"2023","journal-title":"Lancet Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/2\/61\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:53:15Z","timestamp":1760104395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/2\/61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["curroncol31020061"],"URL":"https:\/\/doi.org\/10.3390\/curroncol31020061","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]}}}