{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T21:23:45Z","timestamp":1793654625855,"version":"4.5.1"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Ovarian transposition (OT) has been proposed as a protective measure against radiation-induced damage to ovarian function and fertility. Despite its historical use, limited research has focused on evaluating endocrine and exocrine ovarian function after OT performed in adolescents and young adults (AYAs) before or during puberty. The purpose of our study was to investigate the fertility, pubertal development, and ovarian function of women with a previous history of OT during childhood, adolescence or young adulthood. In an observational bicentric retrospective study, we included 32 young female cancer patients who underwent OT before the age of 26 between 1990 and 2015 at Lyon L\u00e9on B\u00e9rard Cancer Center or Nancy University Hospital. The mean age at the time of OT was 15.6 years with a cancer diagnosis at 15 \u00b1 4.8 years. Among the 10 women attempting pregnancy post-treatment, 60% achieved successful pregnancies. After a mean follow-up of 9.6 \u00b1 7 years, 74% (17 out of 23) of women recovered spontaneous menstrual cycles (seven out of eight evaluable women with OT before or during puberty). Notably, 35% of women who did not attempt pregnancy demonstrated adequate ovarian reserve. Ovarian reserve and function recovery were influenced by the specific chemotherapy received. Importantly, our findings suggest that OT\u2019s effectiveness on ovarian activity resumption does not significantly differ when performed before or during puberty compared to pubertal stages. This study contributes valuable insights into the long-term reproductive outcomes of young women undergoing OT, emphasizing its potential efficacy in preserving ovarian function and fertility across different developmental stages.<\/jats:p>","DOI":"10.3390\/curroncol31060240","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T12:29:47Z","timestamp":1717417787000},"page":"3177-3188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Fertility Assessment after Ovarian Transposition in Children and Young Women Treated for a Malignant Tumor"],"prefix":"10.3390","volume":"31","author":[{"given":"Julie","family":"Valduga","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Regional Hospital Center, 54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Desmules","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, L\u00e9on B\u00e9rard Cancer Center, Institute for Paediatric Haematology and Oncology, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Claude","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Centre L\u00e9on B\u00e9rard, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Chastagner","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology, University Regional Hospital Center, 54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-5995","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Bernier-Chastagner","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Regional Hospital Center, 54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Marec-Berard","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, L\u00e9on B\u00e9rard Cancer Center, Institute for Paediatric Haematology and Oncology, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7087-5687","authenticated-orcid":false,"given":"Christine","family":"Rousset-Jablonski","sequence":"additional","affiliation":[{"name":"Department of Surgery, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"},{"name":"INSERM U1290 RESHAPE, H\u00f4pital Femme M\u00e8re Enfant, 69500 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref_1","unstructured":"L\u2019Institut National du Cancer (INCa) (2015). 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