{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:34:27Z","timestamp":1787243667882,"version":"build-2736575974"},"reference-count":140,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) represents a significant clinical challenge due to limited therapeutic options and poor prognosis. Beyond mere survivorship, setting up an effective framework to improve functioning and quality of life is an urgent need in the comprehensive management of MPM patients. Therefore, this study aims to review the current understanding of MPM sequelae and the effectiveness of rehabilitative interventions in the holistic approach to MPM. A narrative review was conducted to summarize MPM sequelae and their impact on functioning, disability, and quality of life, focusing on rehabilitation interventions in MPM management and highlighting gaps in knowledge and areas for further investigation. Our findings showed that MPM patients experience debilitating symptoms, including fatigue, dyspnea, pain, and reduced exercise tolerance, decreasing quality of life. Supportive and rehabilitative interventions, including pulmonary rehabilitation, physical exercise improvement, psychological support, pain management, and nutritional supplementation, seem promising approaches in relieving symptoms and improving quality of life but require further research. These programs emphasize the pivotal synergy among patient-tailored plans, multidisciplinary team involvement, and disease-specific focus. Despite advancements in therapeutic management, MPM remains a challenging disease with limited effective interventions that should be adapted to disease progressions. Rehabilitative strategies are essential to mitigate symptoms and improve the quality of life in MPM patients. Further research is needed to establish evidence-based guidelines for rehabilitative interventions tailored to the unique needs of MPM patients.<\/jats:p>","DOI":"10.3390\/curroncol31080322","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T11:54:19Z","timestamp":1722945259000},"page":"4318-4337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rehabilitation for Functioning and Quality of Life in Patients with Malignant Pleural Mesothelioma: A Scoping Review"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-1485","authenticated-orcid":false,"given":"Lorenzo","family":"Lippi","sequence":"first","affiliation":[{"name":"Department of Scientific Research, Off-Campus Semmelweis University of Budapest, Campus LUdeS Lugano (CH), 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-8346","authenticated-orcid":false,"given":"Alessandro","family":"de Sire","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Catanzaro \u201cMagna Graecia\u201d, 88100 Catanzaro, Italy"},{"name":"Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro Magna Graecia, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-1719","authenticated-orcid":false,"given":"Vittorio","family":"Aprile","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-2497","authenticated-orcid":false,"given":"Dario","family":"Calafiore","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, ASST Carlo Poma, 46100 Mantova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-8540","authenticated-orcid":false,"given":"Arianna","family":"Folli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Eastern Piedmont \u201cA. Avogadro\u201d, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fjorelo","family":"Refati","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Eastern Piedmont \u201cA. Avogadro\u201d, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5902-3205","authenticated-orcid":false,"given":"Andrea","family":"Balduit","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Burlo Garofolo, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-1274","authenticated-orcid":false,"given":"Alessandro","family":"Mangogna","sequence":"additional","affiliation":[{"name":"Institute of Pathological Anatomy, Department of Medicine, University of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-1000","authenticated-orcid":false,"given":"Mariia","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Division of Pathology, European Institute of Oncology, IRCCS, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Venetis","sequence":"additional","affiliation":[{"name":"Division of Pathology, European Institute of Oncology, IRCCS, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-9131","authenticated-orcid":false,"given":"Nicola","family":"Fusco","sequence":"additional","affiliation":[{"name":"Division of Pathology, European Institute of Oncology, IRCCS, 20141 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-0681","authenticated-orcid":false,"given":"Marco","family":"Invernizzi","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Eastern Piedmont \u201cA. Avogadro\u201d, 28100 Novara, Italy"},{"name":"Translational Medicine, Dipartimento Attivit\u00e0 Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1183\/16000617.0063-2016","article-title":"Malignant pleural mesothelioma: An update on investigation, diagnosis and treatment","volume":"25","author":"Bibby","year":"2016","journal-title":"Eur. Respir. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rossini, M., Rizzo, P., Bononi, I., Clementz, A., Ferrari, R., Martini, F., and Tognon, M.G. (2018). New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma. Front. Oncol., 8.","DOI":"10.3389\/fonc.2018.00091"},{"key":"ref_3","first-page":"S238","article-title":"Management of malignant pleural mesothelioma-The European experience","volume":"6","author":"Opitz","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/0300891620926239","article-title":"Analysis of survival of patients with metastatic malignant pleural mesothelioma","volume":"107","author":"Bille","year":"2021","journal-title":"Tumori J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S298","DOI":"10.21037\/jtd.2018.01.44","article-title":"Diaphragmatic and pericardial reconstruction after surgery for malignant pleural mesothelioma","volume":"10","author":"Solli","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1002\/cncr.33120","article-title":"Pharmacokinetics, safety, and activity of trabectedin as first-line treatment in elderly patients who are affected by advanced sarcoma and are unfit to receive standard chemotherapy: A phase 2 study (TR1US study) from the Italian Sarcoma Group","volume":"126","author":"Grosso","year":"2020","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.annonc.2019.12.009","article-title":"Lurbinectedin as second- or third-line palliative therapy in malignant pleural mesothelioma: An international, multi-centre, single-arm, phase II trial (SAKK 17\/16)","volume":"31","author":"Metaxas","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.ejso.2017.02.010","article-title":"Is less also better? A single-institution experience on treatment of early stage Malignant Pleural Mesothelioma","volume":"43","author":"Bertoglio","year":"2017","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/ccr3.1775","article-title":"Management of recurrent pleural mesothelioma: Successful rechallenge with nintedanib in combination with chemotherapy","volume":"6","author":"Grosso","year":"2018","journal-title":"Clin. Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Aprile, V., Lenzini, A., Lococo, F., Bacchin, D., Korasidis, S., Mastromarino, M.G., Guglielmi, G., Palmiero, G., Ambrogi, M.C., and Lucchi, M. (2021). Hyperthermic Intrathoracic Chemotherapy for Malignant Pleural Mesothelioma: The Forefront of Surgery-Based Multimodality Treatment. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173801"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1200\/JCO.2005.04.3190","article-title":"Phase II study of pemetrexed plus carboplatin in malignant pleural mesothelioma","volume":"24","author":"Ceresoli","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/JTO.0b013e31817c73d6","article-title":"Pemetrexed plus cisplatin or pemetrexed plus carboplatin for chemona\u00efve patients with malignant pleural mesothelioma: Results of the International Expanded Access Program","volume":"3","author":"Santoro","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrc.2017.42","article-title":"Novel insights into mesothelioma biology and implications for therapy","volume":"17","author":"Yap","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0140-6736(14)60418-9","article-title":"Efficacy and cost of video-assisted thoracoscopic partial pleurectomy versus talc pleurodesis in patients with malignant pleural mesothelioma (MesoVATS): An open-label, randomised, controlled trial","volume":"384","author":"Rintoul","year":"2014","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1470-2045(11)70149-8","article-title":"Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: Clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study","volume":"12","author":"Treasure","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(14)60795-9","article-title":"Surgical resection of mesothelioma: An evidence-free practice","volume":"384","author":"Lee","year":"2014","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1183\/09031936.00063109","article-title":"Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma","volume":"35","author":"Scherpereel","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mastromarino, M.G., Lenzini, A., Aprile, V., Al\u00ec, G., Bacchin, D., Korasidis, S., Ambrogi, M.C., and Lucchi, M. (2022). New Insights in Pleural Mesothelioma Classification Update: Diagnostic Traps and Prognostic Implications. Diagnostics, 12.","DOI":"10.3390\/diagnostics12122905"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jtho.2016.04.028","article-title":"Consensus Report of the 2015 Weinman International Conference on Mesothelioma","volume":"11","author":"Carbone","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.21037\/jtd.2017.09.142","article-title":"Endoscopic diagnosis and management of pleural effusion in malignant pleural mesothelioma","volume":"10","author":"Ceruti","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mcna.2010.01.003","article-title":"Respiratory chest pain: Diagnosis and treatment","volume":"94","author":"Brims","year":"2010","journal-title":"Med. Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2354.2009.01162.x","article-title":"Living with mesothelioma. A literature review","volume":"19","author":"Moore","year":"2010","journal-title":"Eur. J. Cancer Care"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Invernizzi, M., Kim, J., and Fusco, N. (2020). Editorial: Quality of Life in Breast Cancer Patients and Survivors. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.620574"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Invernizzi, M., de Sire, A., Lippi, L., Venetis, K., Sajjadi, E., Gimigliano, F., Gennari, A., Criscitiello, C., Cisari, C., and Fusco, N. (2020). Impact of Rehabilitation on Breast Cancer Related Fatigue: A Pilot Study. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.556718"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2340\/16501977-2292","article-title":"Effect of postsurgical rehabilitation programmes in patients operated for lung cancer: A systematic review and meta-analysis","volume":"50","author":"Sommer","year":"2018","journal-title":"J. Rehabil. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/bjsports-2017-098032","article-title":"Preoperative exercise halves the postoperative complication rate in patients with lung cancer: A systematic review of the effect of exercise on complications, length of stay and quality of life in patients with cancer","volume":"52","author":"Steffens","year":"2018","journal-title":"Br. J. Sports Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/bjc.2014.312","article-title":"Prognostic factors in elderly patients with malignant pleural mesothelioma: Results of a multicenter survey","volume":"111","author":"Ceresoli","year":"2014","journal-title":"Br. J. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/modpathol.2011.146","article-title":"A nuclear grading system is a strong predictor of survival in epitheloid diffuse malignant pleural mesothelioma","volume":"25","author":"Kadota","year":"2012","journal-title":"Mod. Pathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1200\/JCO.1998.16.1.145","article-title":"Prognostic factors in patients with pleural mesothelioma: The European Organization for Research and Treatment of Cancer experience","volume":"16","author":"Curran","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1378\/chest.113.3.723","article-title":"Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group, B","volume":"113","author":"Herndon","year":"1998","journal-title":"Chest"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jtho.2015.12.108","article-title":"A Novel Clinical Prediction Model for Prognosis in Malignant Pleural Mesothelioma Using Decision Tree Analysis","volume":"11","author":"Brims","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/sonc.2002.30299","article-title":"Prognostic factors in mesothelioma","volume":"29","author":"Steele","year":"2002","journal-title":"Semin. Oncol."},{"key":"ref_34","first-page":"1857","article-title":"Cyclooxygenase-2 expression is a novel prognostic factor in malignant mesothelioma","volume":"8","author":"Edwards","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1016\/j.cllc.2019.04.010","article-title":"Shorter Survival in Malignant Pleural Mesothelioma Patients with High PD-L1 Expression Associated with Sarcomatoid or Biphasic Histology Subtype: A Series of 214 Cases from the Bio-MAPS Cohort","volume":"20","author":"Brosseau","year":"2019","journal-title":"Clin. Lung Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/JTO.0b013e3182417da5","article-title":"Plasma cell membrane localization of c-MET predicts longer survival in patients with malignant mesothelioma: A series of 157 cases from the MESOPATH Group","volume":"7","author":"Levallet","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1158\/1078-0432.CCR-10-2873","article-title":"Thymidylate synthase and excision repair cross-complementing group-1 as predictors of responsiveness in mesothelioma patients treated with pemetrexed\/carboplatin","volume":"17","author":"Zucali","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/S0140-6736(03)14794-0","article-title":"Mesothelin-family proteins and diagnosis of mesothelioma","volume":"362","author":"Robinson","year":"2003","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1309\/F1B64CL7H8VJKEAF","article-title":"Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis","volume":"124","author":"Hassan","year":"2005","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1158\/1078-0432.CCR-06-2161","article-title":"Mesothelin expression in human lung cancer","volume":"13","author":"Ho","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/carcin\/bgu227","article-title":"Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival","volume":"36","author":"Baumann","year":"2015","journal-title":"Carcinogenesis"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(20)32714-8","article-title":"First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): A multicentre, randomised, open-label, phase 3 trial","volume":"397","author":"Baas","year":"2021","journal-title":"Lancet"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(15)01238-6","article-title":"Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): A randomised, controlled, open-label, phase 3 trial","volume":"387","author":"Zalcman","year":"2016","journal-title":"Lancet"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.lungcan.2014.03.006","article-title":"Vinorelbine and gemcitabine as second- or third-line therapy for malignant pleural mesothelioma","volume":"84","author":"Zauderer","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S1470-2045(21)00404-6","article-title":"Randomized phase II study on gemcitabine with or without ramucirumab as second-line treatment for advanced malignant pleural mesothelioma (MPM): Results of Italian Rames Study","volume":"22","author":"Pinto","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/S1470-2045(21)00471-X","article-title":"Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): A multicentre, double-blind, randomised, phase 3 trial","volume":"22","author":"Fennell","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thoraxjnl-2017-211321","article-title":"British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma","volume":"73","author":"Woolhouse","year":"2018","journal-title":"Thorax"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.lungcan.2015.05.021","article-title":"Research priorities in mesothelioma: A James Lind Alliance Priority Setting Partnership","volume":"89","author":"Stephens","year":"2015","journal-title":"Lung Cancer"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10147-015-0925-1","article-title":"Trimodality strategy for treating malignant pleural mesothelioma: Results of a feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation (Japan Mesothelioma Interest Group 0601 Trial)","volume":"21","author":"Hasegawa","year":"2016","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S1470-2045(15)00208-9","article-title":"Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17\/04): A randomised, international, multicentre phase 2 trial","volume":"16","author":"Stahel","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"200226","DOI":"10.1183\/16000617.0226-2020","article-title":"Update on biology and management of mesothelioma","volume":"30","author":"Asciak","year":"2021","journal-title":"Eur. Respir. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1001\/jama.2015.16840","article-title":"Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy among Patients with Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial","volume":"314","author":"Rahman","year":"2015","journal-title":"JAMA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1001\/jama.2012.5535","article-title":"Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: The TIME2 randomized controlled trial","volume":"307","author":"Davies","year":"2012","journal-title":"JAMA"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1001\/jama.2017.17426","article-title":"Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients with Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial","volume":"318","author":"Thomas","year":"2017","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"975","DOI":"10.6004\/jnccn.2012.0102","article-title":"Optimal management of malignant pleural effusions (results of CALGB 30102)","volume":"10","author":"Demmy","year":"2012","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1097\/JTO.0b013e3182208e3f","article-title":"Recommendations for uniform definitions of surgical techniques for malignant pleural mesothelioma: A consensus report of the international association for the study of lung cancer international staging committee and the international mesothelioma interest group","volume":"6","author":"Rice","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e038892","DOI":"10.1136\/bmjopen-2020-038892","article-title":"Mesothelioma and Radical Surgery 2 (MARS 2): Protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma","volume":"10","author":"Lim","year":"2020","journal-title":"BMJ Open"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ejon.2010.01.003","article-title":"Quality of life, symptom experience and distress of lung cancer patients undergoing chemotherapy","volume":"14","author":"Akin","year":"2010","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.lungcan.2013.11.014","article-title":"Low physical activity levels and functional decline in individuals with lung cancer","volume":"83","author":"Granger","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/JTO.0b013e31819e77e8","article-title":"Prognostic value of the six-minute walk in advanced non-small cell lung cancer","volume":"4","author":"Kasymjanova","year":"2009","journal-title":"J. Thorac. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Guglielmucci, F., Franzoi, I.G., Bonafede, M., Borgogno, F.V., Grosso, F., and Granieri, A. (2018). \u201cThe Less I Think About It, the Better I Feel\u201d: A Thematic Analysis of the Subjective Experience of Malignant Mesothelioma Patients and Their Caregivers. Front. Psychol., 9.","DOI":"10.3389\/fpsyg.2018.00205"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e19180","DOI":"10.2196\/19180","article-title":"Advanced Symptom Management System for Patients with Malignant Pleural Mesothelioma (ASyMSmeso): Mixed Methods Study","volume":"22","author":"Maguire","year":"2020","journal-title":"J. Med. Internet Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Schwartz, R.M., Lieberman-Cribbin, W., Wolf, A., Flores, R.M., and Taioli, E. (2018). Systematic review of quality of life following pleurectomy decortication and extrapleural pneumonectomy for malignant pleural mesothelioma. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-5064-4"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/icvts\/ivab139","article-title":"Quality of life and lung function after pleurectomy\/decortication for malignant pleural mesothelioma","volume":"33","author":"Nakamichi","year":"2021","journal-title":"Interact. CardioVasc. Thorac. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/cncr.20315","article-title":"Adapting the Lung Cancer Symptom Scale (LCSS) to mesothelioma: Using the LCSS-Meso conceptual model for validation","volume":"101","author":"Hollen","year":"2004","journal-title":"Cancer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/0825859720948975","article-title":"Symptom Burden and Unmet Needs in Malignant Pleural Mesothelioma: Exploratory Analyses from the RESPECT-Meso Study","volume":"36","author":"Hoon","year":"2021","journal-title":"J. Palliat. Care"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1164\/rccm.201309-1634ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Key concepts and advances in pulmonary rehabilitation","volume":"188","author":"Spruit","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Olivier, C., Grosbois, J.M., Cortot, A.B., Peres, S., Heron, C., Delourme, J., Gierczynski, M., Hoorelbeke, A., Scherpereel, A., and Le Rouzic, O. (2018). Real-life feasibility of home-based pulmonary rehabilitation in chemotherapy-treated patients with thoracic cancers: A pilot study. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4102-6"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/s41430-019-0418-9","article-title":"Body composition and nutritional status in malignant pleural mesothelioma: Implications for activity levels and quality of life","volume":"73","author":"Jeffery","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(05)67025-0","article-title":"Malignant mesothelioma","volume":"366","author":"Robinson","year":"2005","journal-title":"Lancet"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00520-012-1569-6","article-title":"Health-related quality of life and inflammatory markers in malignant pleural mesothelioma","volume":"21","author":"Kao","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Invernizzi, M., Lippi, L., Folli, A., Turco, A., Zattoni, L., Maconi, A., de Sire, A., and Fusco, N. (2022). Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.930361"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Ferrillo, M., Migliario, M., Marotta, N., Lippi, L., Antonelli, A., Calafiore, D., Ammendolia, V., Fortunato, L., Ren\u00f2, F., and Giudice, A. (2022). Oral Health in Breast Cancer Women with Vitamin D Deficiency: A Machine Learning Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11164662"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.clnu.2017.05.027","article-title":"Effects of nutrition and physical exercise intervention in palliative cancer patients: A randomized controlled trial","volume":"37","author":"Uster","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s40520-021-02073-w","article-title":"Impact of exercise training on muscle mitochondria modifications in older adults: A systematic review of randomized controlled trials","volume":"34","author":"Lippi","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Lippi, L., de Sire, A., Folli, A., Turco, A., Moalli, S., Marcasciano, M., Ammendolia, A., and Invernizzi, M. (2024). Obesity and Cancer Rehabilitation for Functional Recovery and Quality of Life in Breast Cancer Survivors: A Comprehensive Review. Cancers, 16.","DOI":"10.3390\/cancers16030521"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.lungcan.2007.07.008","article-title":"Pneumonectomy: Post-operative quality of life and lung function","volume":"58","author":"Ilonen","year":"2007","journal-title":"Lung Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1590\/S1806-37132009000600005","article-title":"Assessment of pulmonary function and quality of life in patients submitted to pulmonary resection for cancer","volume":"35","author":"Lima","year":"2009","journal-title":"J. Bras. Pneumol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ejcts.2010.01.008","article-title":"Effect of induction chemotherapy on lung function and exercise capacity in patients affected by malignant pleural mesothelioma","volume":"37","author":"Marulli","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1245\/s10434-011-2171-8","article-title":"Clinical impact of extrapleural pneumonectomy for malignant pleural mesothelioma","volume":"19","author":"Ambrogi","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1007\/s00520-021-06171-3","article-title":"Physical function predicts mortality in patients with cancer: A systematic review and meta-analysis of observational studies","volume":"29","author":"Nakano","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"de Sire, A., Fusco, N., Sajjadi, E., Lippi, L., Cisari, C., and Invernizzi, M. (2021). Lymphedema Rehabilitation Using Self-Adaptive Inelastic Compression in Breast Cancer: A Proof-of-Principle Study. Appl. Sci., 11.","DOI":"10.3390\/app11041901"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.rehab.2019.04.007","article-title":"Blurred lines between axillary web syndrome and Mondor\u2019s disease after breast cancer surgery: A case report","volume":"63","author":"Invernizzi","year":"2020","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_84","first-page":"8028","article-title":"Axillary web syndrome in women after breast cancer surgery referred to an Oncological Rehabilitation Unit: Which are the main risk factors? A retrospective case-control study","volume":"24","author":"Losco","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_85","first-page":"4476","article-title":"Three-dimensional laser scanning as a reliable and reproducible diagnostic tool in breast cancer related lymphedema rehabilitation: A proof-of-principle study","volume":"24","author":"Losco","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s13665-016-0133-0","article-title":"Nutrition, exercise, and complementary medicine: Potential role in mesothelioma?","volume":"5","author":"Muruganandan","year":"2016","journal-title":"Curr. Pulmonol. Rep."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1007\/s00520-019-04704-5","article-title":"Physical function and health-related quality of life in the convalescent phase in surgically treated patients with malignant pleural mesothelioma","volume":"27","author":"Tanaka","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00520-017-3666-z","article-title":"Physical function and health-related quality of life in patients undergoing surgical treatment for malignant pleural mesothelioma","volume":"25","author":"Tanaka","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.pmrj.2016.03.010","article-title":"Pulmonary Rehabilitation in Lung Cancer","volume":"8","author":"Wang","year":"2016","journal-title":"PM&R"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/bmj.318.7188.901","article-title":"Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer","volume":"318","author":"Bredin","year":"1999","journal-title":"BMJ"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1191\/0269216303pm752oa","article-title":"Breathlessness clinics within specialist palliative care settings can improve the quality of life and functional capacity of patients with lung cancer","volume":"17","author":"Hately","year":"2003","journal-title":"Palliat. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.lungcan.2010.03.007","article-title":"A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study","volume":"70","author":"Barton","year":"2010","journal-title":"Lung Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Johnson, M.J., Kanaan, M., Richardson, G., Nabb, S., Torgerson, D., English, A., Barton, R., and Booth, S. (2015). A randomised controlled trial of three or one breathing technique training sessions for breathlessness in people with malignant lung disease. BMC Med., 13.","DOI":"10.1186\/s12916-015-0453-x"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00520-014-2511-x","article-title":"The effect of resistance inspiratory muscle training in the management of breathlessness in patients with thoracic malignancies: A feasibility randomised trial","volume":"23","author":"Molassiotis","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s40520-020-01589-x","article-title":"Early cardiac rehabilitation: Could it improve functional outcomes and reduce length of stay and sanitary costs in patients aged 75 years or older? A retrospective case-control study","volume":"33","author":"Pizzorno","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"de Sire, A., Lippi, L., Aprile, V., Calafiore, D., Folli, A., D\u2019Abrosca, F., Moalli, S., Lucchi, M., Ammendolia, A., and Invernizzi, M. (2022). Pharmacological, nutritional, and rehabilitative interventions to improve the complex management of osteoporosis in patients with chronic obstructive pulmonary disease: A narrative review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12101626"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.rmed.2005.03.006","article-title":"Inspiratory muscle training in adults with chronic obstructive pulmonary disease: A systematic review","volume":"99","author":"Geddes","year":"2005","journal-title":"Respir. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s40520-018-1090-y","article-title":"Effects of essential amino acid supplementation and rehabilitation on functioning in hip fracture patients: A pilot randomized controlled trial","volume":"31","author":"Invernizzi","year":"2019","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s40520-019-01436-8","article-title":"Myostatin as a potential biomarker to monitor sarcopenia in hip fracture patients undergoing a multidisciplinary rehabilitation and nutritional treatment: A preliminary study","volume":"32","author":"Baricich","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/pon.3122","article-title":"Effects of self-directed stress management training and home-based exercise on quality of life in cancer patients receiving chemotherapy: A randomized controlled trial","volume":"22","author":"Jacobsen","year":"2013","journal-title":"Psycho Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00520-012-1687-1","article-title":"Occupational therapy needs of patients with thoracic cancer at the time of diagnosis: Findings of a dedicated rehabilitation service","volume":"21","author":"Bentley","year":"2012","journal-title":"Support. Care Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0269215519888794","article-title":"Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: A multi-centre randomized controlled feasibility trial","volume":"34","author":"Bayly","year":"2020","journal-title":"Clin. Rehabil."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Bonafede, M., Granieri, A., Binazzi, A., Mensi, C., Grosso, F., Santoro, G., Franzoi, I.G., Marinaccio, A., and Guglielmucci, F. (2020). Psychological Distress after a Diagnosis of Malignant Mesothelioma in a Group of Patients and Caregivers at the National Priority Contaminated Site of Casale Monferrato. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17124353"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/pon.5454","article-title":"What are the psychological effects of mesothelioma on patients and their carers? A scoping review","volume":"29","author":"Sherborne","year":"2020","journal-title":"Psychooncology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/1097-0142(19870215)59:4<850::AID-CNCR2820590432>3.0.CO;2-1","article-title":"A validation study of the WHO method for cancer pain relief","volume":"59","author":"Ventafridda","year":"1987","journal-title":"Cancer."},{"key":"ref_106","first-page":"CD012592","article-title":"Opioids for cancer pain\u2014An overview of Cochrane reviews","volume":"7","author":"Wiffen","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"219","DOI":"10.12968\/hmed.2017.78.4.219","article-title":"Palliative care for patients with mesothelioma","volume":"78","author":"Tinkler","year":"2017","journal-title":"Br. J. Hosp. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1016\/S1470-2045(12)70040-2","article-title":"Use of opioid analgesics in the treatment of cancer pain: Evidence-based recommendations from the EAPC","volume":"13","author":"Caraceni","year":"2012","journal-title":"Lancet Oncol."},{"key":"ref_109","first-page":"CD008943","article-title":"Combination pharmacotherapy for the treatment of neuropathic pain in adults","volume":"7","author":"Chaparro","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1440-1673.1994.tb00177.x","article-title":"Radiotherapy in the treatment of malignant mesothelioma of the pleura, with special reference to its use in palliation","volume":"38","author":"Davis","year":"1994","journal-title":"Australas. Radiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0936-6555(05)80582-5","article-title":"The role of palliative radiotherapy in malignant mesothelioma","volume":"3","author":"Bissett","year":"1991","journal-title":"Clin. Oncol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S1470-2045(16)30095-X","article-title":"Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): A multicentre, open-label, phase 3, randomised controlled trial","volume":"17","author":"Clive","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.1016\/S1470-2045(17)30459-X","article-title":"Radiotherapy for the treatment of malignant pleural mesothelioma","volume":"18","author":"Wu","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/thorax.58.9.809","article-title":"Lung cancer * 8: Management of malignant mesothelioma","volume":"58","author":"Parker","year":"2003","journal-title":"Thorax"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/bmjspcare-2013-000508","article-title":"Cordotomy in mesothelioma-related pain: A systematic review","volume":"4","author":"France","year":"2014","journal-title":"BMJ Support. Palliat. Care"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Bernetti, A., Agostini, F., de Sire, A., Mangone, M., Tognolo, L., Di Cesare, A., Ruiu, P., Paolucci, T., Invernizzi, M., and Paoloni, M. (2021). Neuropathic Pain and Rehabilitation: A Systematic Review of International Guidelines. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010074"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11912-020-00979-8","article-title":"Multidisciplinary Outpatient Cancer Rehabilitation Can Improve Cancer Patients Physical and Psychosocial Status-a Systematic Review","volume":"22","author":"Kudre","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1093\/annonc\/mdj073","article-title":"A randomised trial in malignant mesothelioma (M) of early (E) versus delayed (D) chemotherapy in symptomatically stable patients: The MED trial","volume":"17","author":"Watkins","year":"2006","journal-title":"Ann. Oncol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0140-6736(08)60727-8","article-title":"Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): A multicentre randomised trial","volume":"371","author":"Muers","year":"2008","journal-title":"Lancet"},{"key":"ref_120","first-page":"CD009553","article-title":"Multidisciplinary rehabilitation for follow-up of women treated for breast cancer","volume":"12","author":"Khan","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"16","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/jnc.14001","article-title":"Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex","volume":"141","author":"Tsuda","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Farquhar, M.C., Prevost, A.T., McCrone, P., Brafman-Price, B., Bentley, A., Higginson, I.J., Todd, C., and Booth, S. (2014). Is a specialist breathlessness service more effective and cost-effective for patients with advanced cancer and their carers than standard care? Findings of a mixed-method randomised controlled trial. BMC Med., 31.","DOI":"10.1186\/s12916-014-0194-2"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev-immunol-020711-075008","article-title":"Cancer and inflammation: An old intuition with rapidly evolving new concepts","volume":"30","author":"Trinchieri","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ebiom.2018.10.034","article-title":"P53, GHRH, inflammation and cancer","volume":"37","author":"Barabutis","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/ni.3754","article-title":"Nutrition, inflammation and cancer","volume":"18","author":"Zitvogel","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1758835920971421","DOI":"10.1177\/1758835920971421","article-title":"Biomarker-guided targeted and immunotherapies in malignant pleural mesothelioma","volume":"12","author":"Yang","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Yoshikawa, Y., Kuribayashi, K., Minami, T., Ohmuraya, M., and Kijima, T. (2020). Epigenetic Alterations and Biomarkers for Immune Checkpoint Inhibitors-Current Standards and Future Perspectives in Malignant Pleural Mesothelioma Treatment. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.554570"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"102089","DOI":"10.1016\/j.ctrv.2020.102089","article-title":"Cellular immunotherapy in breast cancer: The quest for consistent biomarkers","volume":"90","author":"Venetis","year":"2020","journal-title":"Cancer Treat. Rev."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.annonc.2020.09.009","article-title":"A multicentre randomised phase III trial comparing pembrolizumab versus single-agent chemotherapy for advanced pre-treated malignant pleural mesothelioma: The European Thoracic Oncology Platform (ETOP 9-15) PROMISE-meso trial","volume":"31","author":"Popat","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S1470-2045(20)30462-9","article-title":"Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): A multicentre, single-arm, phase 2 trial with a safety run-in","volume":"21","author":"Nowak","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S2213-2600(18)30420-X","article-title":"Ipilimumab and nivolumab in the treatment of recurrent malignant pleural mesothelioma (INITIATE): Results of a prospective, single-arm, phase 2 trial","volume":"7","author":"Disselhorst","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Holmen Olofsson, G., Jensen, A.W.P., Idorn, M., and Thor Straten, P. (2020). Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113816"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/jnci\/djs207","article-title":"Physical activity, biomarkers, and disease outcomes in cancer survivors: A systematic review","volume":"104","author":"Friedenreich","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/j.bbi.2012.05.001","article-title":"Effects and potential mechanisms of exercise training on cancer progression: A translational perspective","volume":"30","author":"Betof","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"508","DOI":"10.23736\/S1973-9087.20.06435-7","article-title":"Systematic rapid living review on rehabilitation needs due to COVID-19: Update to May 31st, 2020","volume":"56","author":"Andrenelli","year":"2020","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Roccuzzo, A., Molinero-Mourelle, P., Ferrillo, M., Cobo-V\u00e1zquez, C., Sanchez-Labrador, L., Ammendolia, A., Migliario, M., and de Sire, A. (2021). Type I Collagen-Based Devices to Treat Nerve Injuries after Oral Surgery Procedures. A Systematic Review. Appl. Sci., 11.","DOI":"10.3390\/app11093927"},{"key":"ref_138","first-page":"839","article-title":"Rehabilitation and COVID-19: The Cochrane Rehabilitation 2020 rapid living systematic review. Update as of August 31st, 2020","volume":"56","author":"Andrenelli","year":"2020","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_139","first-page":"181","article-title":"Rehabilitation and COVID-19: A rapid living systematic review by Cochrane Rehabilitation Field updated as of December 31st, 2020 and synthesis of the scientific literature of 2020","volume":"57","author":"Andrenelli","year":"2021","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_140","first-page":"908","article-title":"Exercise in Regulation of Inflammation-Immune Axis Function in Cancer Initiation and Progression","volume":"29","author":"Koelwyn","year":"2015","journal-title":"Oncology"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/8\/322\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:26:15Z","timestamp":1760109975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/8\/322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":140,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["curroncol31080322"],"URL":"https:\/\/doi.org\/10.3390\/curroncol31080322","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]}}}