{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:10:02Z","timestamp":1767845402774,"version":"3.49.0"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Breast metastasis originating from a primary lung tumor is exceedingly rare and can present challenges in distinguishing it from primary breast cancer. This case report discusses the management of a 64-year-old woman who initially presented with a nodule in her left breast. A biopsy revealed an infiltrating ductal carcinoma. Despite negative BRCA genetic testing, her significant family history of cancer and the presence of a newly detected right breast lesion led to a bilateral mastectomy. Post-operative imaging identified multiple hypodense nodules and a spiculated pulmonary nodule, necessitating further investigation. An endoscopic lung biopsy confirmed a primary pulmonary carcinoma with histological features similar to the breast carcinoma, suggesting the lung as the primary source. This case highlights the complexity of differentiating breast metastasis originating from a lung tumor and primary breast cancer. It underscores the importance of comprehensive diagnostic evaluations and the consideration of extramammary origins in metastatic cases. The findings emphasize the role of multidisciplinary teams in managing such rare and challenging cases and highlight the necessity for thorough and repeated assessments in atypical breast cancer presentations.<\/jats:p>","DOI":"10.3390\/curroncol31080350","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T12:40:07Z","timestamp":1723812007000},"page":"4695-4703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Breast Metastasis from a Primary Lung Tumor: Case Report"],"prefix":"10.3390","volume":"31","author":[{"given":"Raquel","family":"Diaz","sequence":"first","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences\u2014DISC, University of Genova, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Murelli","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences\u2014DISC, University of Genova, 16132 Genova, Italy"},{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3826-874X","authenticated-orcid":false,"given":"Letizia","family":"Cuniolo","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences\u2014DISC, University of Genova, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cornacchia","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Depaoli","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Margarino","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Boccardo","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gipponi","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Franchelli","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Pesce","sequence":"additional","affiliation":[{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Massa","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2413-7573","authenticated-orcid":false,"given":"Silvia","family":"Bozzano","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences\u2014DISC, University of Genova, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Barbero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco De","family":"Cian","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences\u2014DISC, University of Genova, 16132 Genova, Italy"},{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1279-5299","authenticated-orcid":false,"given":"Piero","family":"Fregatti","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Integrated Sciences\u2014DISC, University of Genova, 16132 Genova, Italy"},{"name":"Breast Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genova, 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