{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:14:06Z","timestamp":1792502046957,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Extensive surgery on advanced-stage epithelial ovarian cancer is associated with increased postoperative morbidity, which may cause a delay in or omission of chemotherapy. We examined postoperative complications and their effects on adjuvant treatment in patients undergoing primary debulking surgery (PDS). Methods: Stage IIIC-IV epithelial ovarian cancer patients who underwent PDS between January 2013 and December 2020 were included. Patients were divided into two groups according to the radicality of the operation, i.e., extensive or standard surgery, and their outcomes were compared. Results: In total, 172 patients were included; 119 underwent extensive surgery, and 53 had standard surgery. Clavien\u2013Dindo grade 3\u20135 (CDC 3+) complications were detected in 41.2% of patients after extensive operations and in 17% after standard surgery (p = 0.002). The most common CDC 3+ complication was pleural effusion. Despite the difference in the complication rates, the delay in chemotherapy did not differ between the extensive and standard groups (p = 0.98). Conclusions: Complications are common after PDS. Extensive surgery increases the complication rate, but most complications can be treated effectively; therefore, a delay in adjuvant treatment is rare.<\/jats:p>","DOI":"10.3390\/curroncol31090417","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T09:23:04Z","timestamp":1726737784000},"page":"5630-5642","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Postoperative Complications of Upfront Ovarian Cancer Surgery and Their Effects on Chemotherapy Delay"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-5551","authenticated-orcid":false,"given":"Julia","family":"Heikkinen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kuopio University Hospital, 70210 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"K\u00e4rkk\u00e4inen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kuopio University Hospital, 70210 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja-Liisa","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Central Finland\u2019s Hospital Nova, 40620 Jyv\u00e4skyl\u00e4, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-4180","authenticated-orcid":false,"given":"Maarit","family":"Anttila","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kuopio University Hospital, 70210 Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ejca.2018.07.005","article-title":"Cancer Incidence and Mortality Patterns in Europe: Estimates for 40 Countries and 25 Major Cancers in 2018","volume":"103","author":"Ferlay","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3322\/caac.21456","article-title":"Ovarian Cancer Statistics, 2018","volume":"68","author":"Torre","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.annonc.2023.07.011","article-title":"Newly Diagnosed and Relapsed Epithelial Ovarian Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up","volume":"34","author":"Harter","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1097\/IGC.0000000000001041","article-title":"European Society of Gynaecological Oncology (ESGO) Guidelines for Ovarian Cancer Surgery","volume":"27","author":"Querleu","year":"2017","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cncr.24149","article-title":"Role of Surgical Outcome as Prognostic Factor in Advanced Epithelial Ovarian Cancer: A Combined Exploratory Analysis of 3 Prospectively Randomized Phase 3 Multicenter Trials: By the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzin","volume":"115","author":"Bois","year":"2009","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1245\/s10434-010-0964-9","article-title":"Influence of Residual Tumor on Outcome in Ovarian Cancer Patients with FIGO Stage IV Disease","volume":"17","author":"Wimberger","year":"2010","journal-title":"Ann. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ygyno.2017.08.003","article-title":"Associations between Residual Disease and Survival in Epithelial Ovarian Cancer by Histologic Type","volume":"147","author":"Melamed","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/IGC.0000000000000690","article-title":"Minimal Macroscopic Residual Disease (0.1\u20131 cm). Is It Still a Surgical Goal in Advanced Ovarian Cancer?","volume":"26","author":"Chiva","year":"2016","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/1471-0528.15423","article-title":"The NICE Classification for \u2018Ultra-Radical (Extensive) Surgery for Advanced Ovarian Cancer\u2019 Guidance Does Not Meaningfully Predict Postoperative Complications: A Cohort Study","volume":"126","author":"Phillips","year":"2019","journal-title":"BJOG"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ygyno.2011.08.027","article-title":"Defining the Limits of Radical Cytoreductive Surgery for Ovarian Cancer","volume":"123","author":"Wright","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1097\/IGC.0000000000001325","article-title":"Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery","volume":"28","author":"Castro","year":"2018","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1136\/ijgc-2020-001248","article-title":"Quality Indicators for Advanced Ovarian Cancer Surgery from the European Society of Gynaecological Oncology (ESGO): 2020 Update","volume":"30","author":"Fotopoulou","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging Classification for Cancer of the Ovary, Fallopian Tube, and Peritoneum","volume":"124","author":"Prat","year":"2014","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/ijgc-2021-002565","article-title":"ESGO\/ISUOG\/IOTA\/ESGE Consensus Statement on Pre-Operative Diagnosis of Ovarian Tumors","volume":"31","author":"Timmerman","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2007.10.495","article-title":"Relationship among Surgical Complexity, Short-Term Morbidity, and Overall Survival in Primary Surgery for Advanced Ovarian Cancer","volume":"197","author":"Aletti","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1097\/IGC.0b013e31826a3559","article-title":"Maximal Cytoreduction in Patients With FIGO Stage IIIC to Stage IV Ovarian, Fallopian, and Peritoneal Cancer in Day-to-Day Practice: A Retrospective French Multicentric Study","volume":"22","author":"Luyckx","year":"2012","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ygyno.2009.03.018","article-title":"Improved Progression-Free and Overall Survival in Advanced Ovarian Cancer as a Result of a Change in Surgical Paradigm","volume":"114","author":"Chi","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ygyno.2022.03.023","article-title":"Improved Survival after Implementation of Ultra-Radical Surgery in Advanced Epithelial Ovarian Cancer: Results from a Tertiary Referral Center","volume":"165","author":"Norppa","year":"2022","journal-title":"Gynecol. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ygyno.2010.09.010","article-title":"Identification of Patient Groups at Highest Risk from Traditional Approach to Ovarian Cancer Treatment","volume":"120","author":"Aletti","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/uog.23654","article-title":"Preoperative Staging of Ovarian Cancer: Comparison between Ultrasound, CT and Whole-Body Diffusion-Weighted MRI (ISAAC Study)","volume":"59","author":"Fischerova","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ygyno.2015.10.025","article-title":"Risk-Prediction Model of Severe Postoperative Complications after Primary Debulking Surgery for Advanced Ovarian Cancer","volume":"140","author":"Kumar","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ygyno.2015.03.043","article-title":"Predictors of Postoperative Morbidity after Cytoreduction for Advanced Ovarian Cancer: Analysis and Management of Complications in Upper Abdominal Surgery","volume":"137","author":"Fischetti","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.21873\/invivo.12174","article-title":"Risk Factors for Severe Complications in Ovarian Cancer Surgery","volume":"34","author":"Egger","year":"2020","journal-title":"Vivo"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2147\/IJWH.S190493","article-title":"Predictive Model for Major Complications after Extensive Abdominal Surgery in Primary Advanced Ovarian Cancer","volume":"11","author":"Llueca","year":"2019","journal-title":"Int. J. Womens Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ygyno.2009.03.011","article-title":"Postoperative Mortality after Primary Cytoreductive Surgery for Advanced Stage Epithelial Ovarian Cancer: A Systematic Review","volume":"114","author":"Gerestein","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ygyno.2020.12.026","article-title":"Appropriate Triage Allows Aggressive Primary Debulking Surgery with Rates of Morbidity and Mortality Comparable to Interval Surgery after Chemotherapy","volume":"160","author":"Narasimhulu","year":"2021","journal-title":"Gynecol. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.5468\/ogs.2020.63.1.64","article-title":"Factors Associated with Surgical Morbidity of Primary Debulking in Epithelial Ovarian Cancer","volume":"63","author":"Tohma","year":"2020","journal-title":"Obs. Gynecol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(14)62223-6","article-title":"Primary Chemotherapy versus Primary Surgery for Newly Diagnosed Advanced Ovarian Cancer (CHORUS): An Open-Label, Randomised, Controlled, Non-Inferiority Trial","volume":"386","author":"Kehoe","year":"2015","journal-title":"Lancet"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1056\/NEJMoa0908806","article-title":"Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer","volume":"363","author":"Vergote","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1136\/ijgc-2020-001640","article-title":"Randomized Trial of Primary Debulking Surgery versus Neoadjuvant Chemotherapy for Advanced Epithelial Ovarian Cancer (SCORPION-NCT01461850)","volume":"30","author":"Fagotti","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ygyno.2018.08.014","article-title":"Continuous Improvement in Primary Debulking Surgery for Advanced Ovarian Cancer: Do Increased Complete Gross Resection Rates Independently Lead to Increased Progression-Free and Overall Survival?","volume":"151","author":"Tseng","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.3802\/jgo.2020.31.e12","article-title":"Efficacy and Safety of Neoadjuvant Chemotherapy versus Primary Debulking Surgery in Patients with Ovarian Cancer: A Meta-Analysis","volume":"31","author":"Lv","year":"2020","journal-title":"J. Gynecol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1136\/ijgc-2019-000682","article-title":"TRUST: Trial of Radical Upfront Surgical Therapy in Advanced Ovarian Cancer (ENGOT Ov33\/AGO-OVAR OP7)","volume":"29","author":"Reuss","year":"2019","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"032","DOI":"10.29328\/journal.cjog.1001126","article-title":"Minimally Invasive Cytoreductive Surgery in Advanced Ovarian Cancer: A Nonselected Consecutive Series of Robotic-Assisted Cases","volume":"6","author":"Natalie","year":"2023","journal-title":"Clin. J. Obstet. Gynecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4293\/108680810X12674612014707","article-title":"Laparoscopic Cytoreduction for Primary Advanced Ovarian Cancer","volume":"14","author":"Fanning","year":"2010","journal-title":"J. Soc. Laparoendosc. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"102391","DOI":"10.1016\/j.bpobgyn.2023.102391","article-title":"Robotic Surgery in Ovarian Cancer","volume":"90","author":"Gallotta","year":"2023","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ygyno.2021.11.012","article-title":"Surgical Outcomes of Diaphragmatic Resection during Cytoreductive Surgery for Advanced Gynecological Ovarian Neoplasia: A Randomized Single Center Clinical Trial\u2014DRAGON","volume":"164","author":"Cianci","year":"2022","journal-title":"Gynecol. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1245\/s10434-017-6005-1","article-title":"Hepatoceliac Lymph Node Involvement in Advanced Ovarian Cancer Patients: Prognostic Role and Clinical Considerations","volume":"24","author":"Gallotta","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygyno.2022.12.023","article-title":"Intrathoracic Surgery as Part of Primary Cytoreduction for Advanced Ovarian Cancer: Going to the next Level\u2014A Memorial Sloan Kettering Cancer Center Study","volume":"170","author":"Kahn","year":"2023","journal-title":"Gynecol. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ygyno.2018.11.001","article-title":"Pattern and Impact of Metastatic Cardiophrenic Lymph Nodes in Advanced Epithelial Ovarian Cancer","volume":"152","author":"Prader","year":"2019","journal-title":"Gynecol. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Park, S.J., Na, K.J., Lee, M., Park, I.K., Chung, H.H., Kang, C.H., Kim, J.W., Park, N.H., Kim, Y.T., and Song, Y.S. (2023). Impact of Supradiaphragmatic Lymphadenectomy on the Survival of Patients in Stage IVB Ovarian Cancer with Thoracic Lymph Node Metastasis. Front. Oncol., 13.","DOI":"10.3389\/fonc.2023.1203127"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ygyno.2006.01.035","article-title":"Influence of Interval between Primary Surgery and Chemotherapy on Short-Term Survival of Patients with Advanced Ovarian, Tubal or Peritoneal Cancer","volume":"102","author":"Paulsen","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1097\/AOG.0b013e31826981de","article-title":"Effect of Radical Cytoreductive Surgery on Omission and Delay of Chemotherapy for Advanced-Stage Ovarian Cancer","volume":"120","author":"Wright","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.ygyno.2016.11.022","article-title":"Chemotherapy Delay after Primary Debulking Surgery for Ovarian Cancer","volume":"144","author":"Seagle","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/annonc\/mdv500","article-title":"Early Initiation of Chemotherapy Following Complete Resection of Advanced Ovarian Cancer Associated with Improved Survival: NRG Oncology\/Gynecologic Oncology Group Study","volume":"27","author":"Tewari","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ygyno.2016.09.004","article-title":"Preoperative Predictors of Delay in Initiation of Adjuvant Chemotherapy in Patients Undergoing Primary Debulking Surgery for Ovarian Cancer","volume":"143","author":"Singh","year":"2016","journal-title":"Gynecol. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ygyno.2017.06.007","article-title":"The Impact of Type and Number of Bowel Resections on Anastomotic Leakage Risk in Advanced Ovarian Cancer Surgery","volume":"146","author":"Grimm","year":"2017","journal-title":"Gynecol. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/9\/417\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:59:14Z","timestamp":1760111954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/9\/417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":47,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["curroncol31090417"],"URL":"https:\/\/doi.org\/10.3390\/curroncol31090417","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]}}}