{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:27:07Z","timestamp":1770812827000,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Gastrectomy, a prevalent surgical procedure for gastric cancer, results in substantial alterations to the gastrointestinal tract, including reduced gastric acid production and significant modifications to the gut microbiota. These changes can impair postoperative recovery, influence metabolic functions, and predispose patients to inflammatory bowel disease (IBD). Studies have shown an increased risk of IBD, particularly Crohn\u2019s disease (CD) and ulcerative colitis (UC), in patients following gastrectomy and bariatric surgeries such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). For instance, patients undergoing RYGB have a higher hazard ratio for developing CD, while SG patients show an increased risk for UC. The surgical alteration of the gastrointestinal tract promotes dysbiosis, with a significant increase in pathogenic bacteria and a decrease in beneficial microbial populations. This dysbiosis can impair the intestinal mucosal barrier and promote systemic inflammation. Understanding the mechanisms behind these changes and their clinical implications is essential for developing effective postoperative management strategies. Probiotics and enhanced recovery after surgery (ERAS) protocols have shown promise in mitigating these adverse effects, improving gut microbiota balance, and enhancing patient outcomes. Further research is necessary to fully elucidate the long-term impacts of gastrectomy on gastrointestinal health and to refine therapeutic approaches for postoperative care.<\/jats:p>","DOI":"10.3390\/curroncol31100430","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T09:16:10Z","timestamp":1727428570000},"page":"5789-5801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Gastrectomy on Inflammatory Bowel Disease Risk in Gastric Cancer Patients: A Critical Analysis"],"prefix":"10.3390","volume":"31","author":[{"given":"Grigorios","family":"Christodoulidis","sequence":"first","affiliation":[{"name":"Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, 41110 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos-Eleftherios","family":"Koumarelas","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, General Hospital of Larissa, 41221 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriaki","family":"Tsagkidou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, General Hospital of Larissa, 41221 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini-Sara","family":"Agko","sequence":"additional","affiliation":[{"name":"Department of ICU, Asklepios Paulinen Clinic Wiesbaden, Geisenheimer Str. 10, 65197 Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitra","family":"Bartzi","sequence":"additional","affiliation":[{"name":"Department of Oncology, 251 Air Force General Hospital, 11525 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Koumarelas","sequence":"additional","affiliation":[{"name":"Department of General Surgery, General Hospital of Nafplio, 21100 Nafplio, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Zacharoulis","sequence":"additional","affiliation":[{"name":"Department of General Surgery, University Hospital of Larissa, University of Thessaly, Biopolis Campus, 41110 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.7150\/jca.29072","article-title":"A Randomised Trial of Probiotics to Reduce Severity of Physiological and Microbial Disorders Induced by Partial Gastrectomy for Patients with Gastric Cancer","volume":"10","author":"Zheng","year":"2019","journal-title":"J. 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