{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:22:19Z","timestamp":1793758939030,"version":"4.6.1"},"reference-count":62,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004738","name":"E-Da Hospital, Taiwan","doi-asserted-by":"publisher","award":["EDAHP105020"],"award-info":[{"award-number":["EDAHP105020"]}],"id":[{"id":"10.13039\/501100004738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Despite the generally good prognosis of differentiated thyroid cancer (DTC), impairments in health-related quality of life (HRQoL) remain a major concern in these patients. This study examined the patterns and predictors of change in mental and physical HRQoL in DTC survivors following radiotherapy ablation. Two hundred patients with DTC who received radiotherapy ablation in southern Taiwan between 2015 and 2018 were interviewed using the Taiwan version of the 36-item Short-form Health Survey (SF-36), the Taiwanese Depression Questionnaire (TDQ), and the Hamilton Rating Scale for Anxiety (HAM-A) at baseline and after 24 and 48 weeks of treatment. The demographic characteristics, thyroid-related factors, recombinant human thyroid-stimulating hormone (rhTSH), and serum calcium level were also collected. Improvements in both mental and physical HRQoL were noted over the first 24 weeks following radiotherapy ablation. Between 24 and 48 weeks, mental HRQoL was increasing, whereas physical HRQoL decreased. Higher levels of anxiety and pain predicted both poor physical and mental HRQoL. Further, higher levels of depression predicted poor mental HRQoL. Additionally, factors such as low income, rhTSH use, elevated TSH levels, low free T4, and higher physical HRQoL were associated with poorer mental HRQoL during the follow-up period. The early detection and intervention of depression, anxiety, and pain should be the objective for programs aiming to improve HRQoL.<\/jats:p>","DOI":"10.3390\/curroncol31110488","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T09:11:47Z","timestamp":1729761107000},"page":"6608-6620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Depression, Anxiety, and Pain Predict Quality of Life in Patients with Differentiated Thyroid Cancer Postradiotherapy Ablation in Taiwan: A 48-Week Follow-Up Study"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6728-0807","authenticated-orcid":false,"given":"Kuan-Ying","family":"Hsieh","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry, Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung 802211, Taiwan"},{"name":"Department of Physical Therapy, I-Shou University, Kaohsiung 840203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Da","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Community Psychiatry, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung 802211, Taiwan"},{"name":"Department of Nursing, Meiho University, Pingtung 906006, Taiwan"},{"name":"Graduate Institute of Psychology, National Chung Cheng University, Chiayi 621301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Sheng","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Chieh","family":"Yen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, E-Da Hospital, Kaohsiung 824005, Taiwan"},{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 840203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3120-7569","authenticated-orcid":false,"given":"Te-Chang","family":"Changchien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, E-Da Hospital, Kaohsiung 824005, Taiwan"},{"name":"School of Medicine, College of Medicine, I-Shou University, Kaohsiung 840203, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.14310\/horm.2002.1260","article-title":"Increasing world incidence of thyroid cancer: Increased detection or higher radiation exposure?","volume":"9","author":"Wartofsky","year":"2010","journal-title":"Hormones"},{"key":"ref_2","unstructured":"Health Promotion Administration, Ministry of Health and Welfare (2022, October 06). 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