{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:37:38Z","timestamp":1789961858155,"version":"4.0.1"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The lifetime risk of breast and ovarian cancer increases substantially for individuals with mutations in BRCA1\/2. The evidence indicates that BRCA1\/2 mutation carriers benefit from early cancer detection and prevention strategies. However, data on the patterns of risk-reducing interventions are lacking. This study investigated the patterns of surveillance and risk-reducing interventions among unaffected BRCA1\/2 mutation carriers. A cohort of unaffected BRCA1\/2 mutation carriers was identified from the Korean Hereditary Breast cAncer (KOHBRA) study database, and a telephone survey was conducted. The survey included questions on the incidence of new cancers, patterns of cancer (breast, ovarian, prostate, other) surveillance, chemoprevention, risk-reducing surgery, and reasons for participating in risk-reducing strategies. Between November 2016 and November 2020, 192 BRCA1\/2 mutation carriers were contacted, of which 83 responded. After excluding 37 responders who refused to participate, 46 participants (15 males, 31 females) were included in the analysis. The mean \u00b1 SD follow-up time was 103 \u00b1 17 months (median 107, range 68~154), and the mean \u00b1 SD age was 31 \u00b1 8 years. Ten BRCA1\/2 mutation carriers developed breast cancer, one developed ovarian cancer, and three developed other cancers. Six BRCA1\/2 mutation carriers (19.4%) underwent annual breast cancer surveillance as recommended by guidelines, while none underwent ovarian or prostate cancer surveillance. Three carriers (9.7%) used chemoprevention for breast cancer. Risk-reducing salpingo-oophorectomy was performed on only one BRCA1\/2 mutation carrier. The rates of breast\/ovarian cancer surveillance, chemoprevention, and risk-reducing surgery were low among unaffected Korean BRCA1\/2 mutation carriers. Given this cohort\u2019s relatively high risk of developing breast cancer, strategies to encourage active participation in risk reduction are needed.<\/jats:p>","DOI":"10.3390\/curroncol31110499","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T11:36:39Z","timestamp":1730806599000},"page":"6767-6777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pattern Anlysis of Risk-Reducing Strategies in Unaffected Korean BRCA1\/2 Mutation Carriers"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8091-6398","authenticated-orcid":false,"given":"Dabin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Min","family":"Ryu","sequence":"additional","affiliation":[{"name":"Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kyung Hee University Hospital at Gangdong, Seoul 05278, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1413-2800","authenticated-orcid":false,"given":"Zisun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Daerim St. Mary\u2019s Hospital, Seoul 07442, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/BST0370597","article-title":"Understanding the functions of BRCA1 in the DNA-damage response","volume":"37","author":"Yun","year":"2009","journal-title":"Biochem. 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