{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T01:53:44Z","timestamp":1794534824738,"version":"4.9.1"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"niversity of S\u00e3o Paulo\u2014Ribeir\u00e3o Preto"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Purpose: Malignant ureteral obstruction is generally associated with a poor disease prognosis; therefore, managing these cases is challenging. We describe our experience in treating malignant ureteral obstruction with urinary diversion and the impact of these procedures on the indication for new antineoplastic therapy and survival. Materials and Methods: We retrospectively reviewed the data of patients with advanced cancer associated with malignant ureteral obstruction who underwent urinary diversion at three tertiary institutions between January 2013 and July 2022. Results: This study included 420 patients (mean age, 58.7 years (range, 18\u201390 years) with a mean follow-up of 20.3 months. Cervical (36.2%) and bladder cancers (18.6%) were the most prevalent primary neo-plastic sites. The mean creatinine values measured before diversion, 30 days after surgery, and most recently were 3.45, 1.84, and 2.59 mg\/dL, respectively. In total, 300 patients (71.4%) received antineoplastic treatment, 195 received palliative treatment, and 105 received curative treatment. After an average of 251.87 postoperative days, 265 (64%) patients died. The mean overall survival was 610.76 days. Patients with prostate and cervical neoplasms had the most prolonged overall survival (573.13 and 549.28 days, respectively), whereas patients with bladder and colorectal cancer had the worst overall survival (480.25 and 370.53 days, respectively). Conclusions: Urinary diversion improves kidney function and opens a therapeutic window for a new line of antineoplastic therapy that provides a cure or increases patient survival.<\/jats:p>","DOI":"10.3390\/curroncol31110523","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T08:09:28Z","timestamp":1731485368000},"page":"7107-7116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Urinary Diversion Can Improve the Chance of Implementing New Therapeutic Lines in Patients with Malignant Ureteral Obstruction: A Multicenter Study"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-7962","authenticated-orcid":false,"given":"Marcelo","family":"Cartapatti","sequence":"first","affiliation":[{"name":"Clinics Hospital, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05508-220, SP, Brazil"},{"name":"S\u00e3o Jos\u00e9 do Rio Preto Medical School (FAMERP), Av. Brigadeiro Faria Lima, 5416-Villa S\u00e3o Pedro, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Dias","family":"Machado","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Mesquita","sequence":"additional","affiliation":[{"name":"S\u00e3o Jos\u00e9 do Rio Preto Medical School (FAMERP), Av. Brigadeiro Faria Lima, 5416-Villa S\u00e3o Pedro, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Freua","sequence":"additional","affiliation":[{"name":"S\u00e3o Jos\u00e9 do Rio Preto Medical School (FAMERP), Av. Brigadeiro Faria Lima, 5416-Villa S\u00e3o Pedro, S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Barretos Cancer Hospital, Barretos 14784-400, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0328-1840","authenticated-orcid":false,"given":"Rodolfo Borges","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Clinics Hospital, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, Ribeir\u00e3o Preto 05508-220, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"ref_1","unstructured":"Wein, A.J. (2016). Chapter 48-Pathophysiology of Urinary Tract Obstruction. Campbell-Walsh Urology, Elsevier. 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Cancer Prev."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/11\/523\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:31:28Z","timestamp":1760113888000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/11\/523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["curroncol31110523"],"URL":"https:\/\/doi.org\/10.3390\/curroncol31110523","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]}}}