{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:19:07Z","timestamp":1771978747740,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with a median overall survival (OS) of 15\u201318 months despite standard treatments. Approximately 8% of GBM cases exhibit genomic alterations in fibroblast growth factor receptors (FGFRs), particularly FGFR1 and FGFR3. Next-generation sequencing techniques have identified various FGFR3 fusions in GBM. This report presents a novel FGFR3 fusion with fatty acid synthase (FASN) in a 41-year-old male diagnosed with GBM. The patient presented with a persistent headache, and imaging revealed a right frontal lobe lesion. Surgical resection and subsequent histopathology confirmed GBM. Initial NGS analysis showed no mutations in the IDH1, IDH2 or H3F3 genes, but revealed a TERT promoter mutation and CDKN2A\/2B and PTEN deletions. Postoperative treatment included radiotherapy and temozolomide. Despite initial management, recurrence occurred four months post-diagnosis, confirmed by MRI and histology. A second surgery identified a novel FGFR3-FASN fusion, alongside increased Ki67 expression. The recurrence was managed with regorafenib and bevacizumab, though complications like hand\u2013foot syndrome and radiation necrosis arose. Despite initial improvement, the patient died 15 months after diagnosis. This case underscores the importance of understanding GBM\u2019s molecular landscape for effective treatment strategies. The novel FGFR3-FASN fusion suggests potential implications for GBM recurrence and lipid metabolism. Further studies are warranted to explore FGFR3-FASN\u2019s role in GBM and its therapeutic targeting.<\/jats:p>","DOI":"10.3390\/curroncol31110539","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:57:54Z","timestamp":1732172274000},"page":"7308-7318","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Fibroblast Growth Factor Receptor 3\u2013Fatty Acid Synthase Gene Fusion in Recurrent Epithelioid Glioblastoma Linked to Aggressive Clinical Progression"],"prefix":"10.3390","volume":"31","author":[{"given":"Miguel A.","family":"Diaz","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology, Hospital Infantil Universitario \u201cNi\u00f1o Jes\u00fas\u201d, Universidad Aut\u00f3noma de Madrid, 28009 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-9561","authenticated-orcid":false,"given":"Felisa","family":"V\u00e1zquez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, Hospital Infantil Universitario \u201cNi\u00f1o Jes\u00fas\u201d, Universidad Aut\u00f3noma de Madrid, 28009 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Garrido","sequence":"additional","affiliation":[{"name":"Neuro-Radiology, Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Arias","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-7096","authenticated-orcid":false,"given":"Julia","family":"Suarez","sequence":"additional","affiliation":[{"name":"Genomics Unit, Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"},{"name":"Health Research Institute (IiSGM), Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-9170","authenticated-orcid":false,"given":"Ismael","family":"Bu\u00f1o","sequence":"additional","affiliation":[{"name":"Genomics Unit, Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"},{"name":"Health Research Institute (IiSGM), Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"},{"name":"Department of Hematology, Hospital General Universitario \u201cGregorio Mara\u00f1\u00f3n\u201d, 28007 Madrid, Spain"},{"name":"Department of Cell Biology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-1473","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Lassaletta","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology, Hospital Infantil Universitario \u201cNi\u00f1o Jes\u00fas\u201d, Universidad Aut\u00f3noma de Madrid, 28009 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noad149","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016\u20132020","volume":"25","author":"Ostrom","year":"2023","journal-title":"Neuro-Oncology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy Plus Concomitant and Adjuvant Temozolomide for Glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/jamaoncol.2022.2844","article-title":"World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas: A Review","volume":"8","author":"Berger","year":"2022","journal-title":"JAMA Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/neuonc\/noaa106","article-title":"Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions","volume":"22","author":"Wen","year":"2020","journal-title":"Neuro-Oncology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1215\/15228517-2007-062","article-title":"Progression-Free Survival: An Important End Point in Evaluating Therapy for Recurrent High-Grade Gliomas","volume":"10","author":"Lamborn","year":"2008","journal-title":"Neuro-Oncology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1158\/1078-0432.CCR-19-0032","article-title":"Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas","volume":"25","author":"Jonsson","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2013.09.034","article-title":"The Somatic Genomic Landscape of Glioblastoma","volume":"155","author":"Brennan","year":"2013","journal-title":"Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/ng.3823","article-title":"Genome-Wide Association Study of Glioma Subtypes Identifies Specific Differences in Genetic Susceptibility to Glioblastoma and Non-Glioblastoma Tumors","volume":"49","author":"Melin","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"De Luca, A., Esposito Abate, R., Rachiglio, A.M., Maiello, M.R., Esposito, C., Schettino, C., Izzo, F., Nasti, G., and Normanno, N. (2020). FGFR Fusions in Cancer: From Diagnostic Approaches to Therapeutic Intervention. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186856"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1158\/1078-0432.CCR-14-3212","article-title":"The FGFR Landscape in Cancer: Analysis of 4853 Tumors by Next-Generation Sequencing","volume":"22","author":"Helsten","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_13","first-page":"3893","article-title":"Comprehensive Identification of FGFR1-4 Alterations in 5557 Chinese Patients with Solid Tumors by Next-Generation Sequencing","volume":"11","author":"Gu","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1101\/gr.180612.114","article-title":"Whole-Genome and Multisector Exome Sequencing of Primary and Post-Treatment Glioblastoma Reveals Patterns of Tumor Evolution","volume":"25","author":"Kim","year":"2015","journal-title":"Genome Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.ccell.2019.02.007","article-title":"Evolutionary Trajectories of IDH(WT) Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years Ahead of Initial Diagnosis","volume":"35","author":"Korber","year":"2019","journal-title":"Cancer Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/bpa.12572","article-title":"BRAF V600E, TERT Promoter Mutations and CDKN2A\/B Homozygous Deletions Are Frequent in Epithelioid Glioblastomas: A Histological and Molecular Analysis Focusing on Intratumoral Heterogeneity","volume":"28","author":"Nakajima","year":"2018","journal-title":"Brain Pathol."},{"key":"ref_17","first-page":"1529","article-title":"Clinicopathologic Features And prognosis of Epithelioid Glioblastoma","volume":"13","author":"Wang","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mondia, M.W.L., Kritselis, M.A., Donahue, J.E., Elinzano, H., Sarangi, S., Bryant, D., Capelletti, M., Korn, W.M., Yu, E., and Yan, S. (2022). Dimorphic Glioblastoma with Glial and Epithelioid Phenotypes: Clonal Evolution and Immune Selection. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.1017087"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/neup.12347","article-title":"A Comprehensive Analysis Identifies BRAF Hotspot Mutations Associated with Gliomas with Peculiar Epithelial Morphology","volume":"37","author":"Hatae","year":"2017","journal-title":"Neuropathology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1158\/1078-0432.CCR-14-2199","article-title":"Detection, Characterization, and Inhibition of FGFR-TACC Fusions in IDH Wild-Type Glioma","volume":"21","author":"Fucci","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1126\/science.1220834","article-title":"Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma","volume":"337","author":"Singh","year":"2012","journal-title":"Science"},{"key":"ref_22","first-page":"475","article-title":"FGFR-TACC Gene Fusions in Human Glioma","volume":"19","author":"Lasorella","year":"2017","journal-title":"Neuro-Oncology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/cac2.12361","article-title":"An Update on the Molecular Biology of Glioblastoma, with Clinical Implications and Progress in Its Treatment","volume":"42","author":"Verdugo","year":"2022","journal-title":"Cancer Commun. (Lond.)"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40478-021-01170-1","article-title":"Novel Targetable FGFR2 and FGFR3 Alterations in Glioblastoma Associate with Aggressive Phenotype and Distinct Gene Expression Programs","volume":"9","author":"Georgescu","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/002215540004800505","article-title":"Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-Sensitive Cells or Cells with high Lipid Metabolism and in Proliferating Fetal Cells","volume":"48","author":"Kusakabe","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101453","DOI":"10.1016\/j.isci.2020.101453","article-title":"Glioblastoma Utilizes Fatty Acids and Ketone Bodies for Growth Allowing Progression During Ketogenic Diet Therapy","volume":"23","author":"Sperry","year":"2020","journal-title":"iScience"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Ricklefs, F.L., Maire, C.L., Matschke, J., Duhrsen, L., Sauvigny, T., Holz, M., Kolbe, K., Peine, S., Herold-Mende, C., and Carter, B. (2020). FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21061931"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/2159-8290.CD-19-0061","article-title":"Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling","volume":"9","author":"Gimple","year":"2019","journal-title":"Cancer Discov."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11060-014-1452-z","article-title":"Overexpression of Fatty Acid Synthase in Human Gliomas Correlates with the WHO Tumor Grade and Inhibition with Orlistat Reduces Cell Viability and Triggers Apoptosis","volume":"118","author":"Grube","year":"2014","journal-title":"J. Neurooncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/sj.bjc.6603350","article-title":"Fatty Acid Synthase: A Novel Target for Antiglioma Therapy","volume":"95","author":"Zhao","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"216329","DOI":"10.1016\/j.canlet.2023.216329","article-title":"Radiation Therapy Promotes Unsaturated Fatty Acids to Maintain Survival of Glioblastoma","volume":"570","author":"Daviaud","year":"2023","journal-title":"Cancer Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40478-021-01205-7","article-title":"Altered Lipid Metabolism Marks Glioblastoma Stem and Non-Stem Cells in Separate Tumor Niches","volume":"9","author":"Shakya","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_33","first-page":"CD013579","article-title":"Treatment Options for Progression or Recurrence of Glioblastoma: A Network Meta-Analysis","volume":"5","author":"McBain","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11060-021-03748-0","article-title":"Second Surgery for Progressive Glioblastoma: A multi-Centre Questionnaire and Cohort-Based Review of Clinical Decision-Making and Patient Outcomes In Current Practice","volume":"153","author":"Brennan","year":"2021","journal-title":"J. Neurooncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1470-2045(23)00275-9","article-title":"Erdafitinib in Patients with Advanced Solid Tumours with FGFR Alterations (RAGNAR): An International, Single-Arm, Phase 2 Study","volume":"24","author":"Pant","year":"2023","journal-title":"Lancet Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1158\/1078-0432.CCR-21-2664","article-title":"Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study","volume":"28","author":"Lassman","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/ijc.25864","article-title":"Regorafenib (BAY 73-4506): A New Oral Multikinase Inhibitor of Angiogenic, Stromal and Oncogenic Receptor Tyrosine Kinases with Potent Preclinical Antitumor Activity","volume":"129","author":"Wilhelm","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1470-2045(18)30675-2","article-title":"Regorafenib Compared with Lomustine in Patients with Relapsed Glioblastoma (REGOMA): A Multicentre, Open-Label, Randomised, Controlled, Phase 2 Trial","volume":"20","author":"Lombardi","year":"2019","journal-title":"Lancet Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11060-022-04066-9","article-title":"Efficacy and Tolerability of Regorafenib in Pretreated Patients with Progressive CNS Grade 3 or 4 Gliomas","volume":"159","author":"Werner","year":"2022","journal-title":"J. Neurooncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1470-2045(08)70125-6","article-title":"Clinical Features, Mechanisms, and Management of Pseudoprogression in Malignant Gliomas","volume":"9","author":"Brandsma","year":"2008","journal-title":"Lancet Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e04604","DOI":"10.1002\/ccr3.4604","article-title":"Distinct MRI Pattern of \u201cPseudoresponse\u201d in Recurrent Glioblastoma Multiforme Treated with Regorafenib: Case Report and Literature Review","volume":"9","author":"Gatto","year":"2021","journal-title":"Clin. Case Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1148\/radiology.217.2.r00nv36377","article-title":"Malignant Gliomas: MR Imaging Spectrum of Radiation Therapy- and Chemotherapy-Induced Necrosis of the Brain After Treatment","volume":"217","author":"Kumar","year":"2000","journal-title":"Radiology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/01.nrl.0000080951.78533.c4","article-title":"Cerebral Radiation Necrosis","volume":"9","author":"Giglio","year":"2003","journal-title":"Neurologist"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11060-006-9241-y","article-title":"Early Necrosis Following Concurrent Temodar and Radiotherapy in Patients with Glioblastoma","volume":"82","author":"Chamberlain","year":"2007","journal-title":"J. Neurooncol."},{"key":"ref_45","first-page":"201","article-title":"Diffusion-Weighted Imaging in the Follow-Up of Treated High-Grade Gliomas: Tumor Recurrence Versus Radiation Injury","volume":"25","author":"Hein","year":"2004","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1124\/mi.4.5.7","article-title":"Mechanisms of Radiation Injury to the Central Nervous System: Implications for Neuroprotection","volume":"4","author":"Wong","year":"2004","journal-title":"Mol. Interv."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijrobp.2006.10.010","article-title":"Effect of Bevacizumab on Radiation Necrosis of the Brain","volume":"67","author":"Gonzalez","year":"2007","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00146880","article-title":"The Cause of Death in Patients with Glioblastoma is Multifactorial: Clinical Factors and Autopsy Findings in 117 Cases of Supratentorial Glioblastoma in Adults","volume":"10","author":"Silbergeld","year":"1991","journal-title":"J. Neurooncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00415-012-6718-9","article-title":"A comprehensive Analysis of Vascular Complications in 3889 Glioma Patients from the German Glioma Network","volume":"260","author":"Seidel","year":"2013","journal-title":"J. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s11060-011-0579-4","article-title":"Ischemic Stroke and Intracranial Hemorrhage in Glioma Patients on Antiangiogenic Therapy","volume":"105","author":"Fraum","year":"2011","journal-title":"J. Neurooncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2217\/cns-2017-0025","article-title":"Radiographic Patterns of Recurrence and Pathologic Correlation in Malignant Gliomas Treated with Bevacizumab","volume":"7","author":"Thomas","year":"2018","journal-title":"CNS Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/11\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:34:12Z","timestamp":1760114052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/31\/11\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":51,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["curroncol31110539"],"URL":"https:\/\/doi.org\/10.3390\/curroncol31110539","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}