{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T21:44:22Z","timestamp":1781559862668,"version":"3.54.5"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Specialty program of the Natural Science Foundation of Beijing Municipality","award":["Z20008"],"award-info":[{"award-number":["Z20008"]}]},{"name":"Key Specialty program of the Natural Science Foundation of Beijing Municipality","award":["BMU2023PYJH009"],"award-info":[{"award-number":["BMU2023PYJH009"]}]},{"name":"Key Specialty program of the Natural Science Foundation of Beijing Municipality","award":["BYSYZD202011"],"award-info":[{"award-number":["BYSYZD202011"]}]},{"name":"Clinical Scientist Training program of Peking University","award":["Z20008"],"award-info":[{"award-number":["Z20008"]}]},{"name":"Clinical Scientist Training program of Peking University","award":["BMU2023PYJH009"],"award-info":[{"award-number":["BMU2023PYJH009"]}]},{"name":"Clinical Scientist Training program of Peking University","award":["BYSYZD202011"],"award-info":[{"award-number":["BYSYZD202011"]}]},{"name":"Hospital Key project","award":["Z20008"],"award-info":[{"award-number":["Z20008"]}]},{"name":"Hospital Key project","award":["BMU2023PYJH009"],"award-info":[{"award-number":["BMU2023PYJH009"]}]},{"name":"Hospital Key project","award":["BYSYZD202011"],"award-info":[{"award-number":["BYSYZD202011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>(1) Background: Volumetric modulated arc therapy (VMAT) can deliver more accurate dose distribution and reduce radiotherapy-induced toxicities for postoperative cervical and endometrial cancer. This study aims to retrospectively analyze the relationship between dosimetric parameters of organs at risk (OARs) and acute toxicities and provide suggestions for the dose constraints. (2) Methods: A total of 164 postoperative cervical and endometrial cancer patients were retrospectively analyzed, and the endpoints were grade \u2265 2 acute urinary toxicity (AUT) and acute lower gastrointestinal toxicity (ALGIT). The normal tissue complication probability (NTCP) model was established using the logistic regression model. Restricted cubic spline (RCS) curves were used to explore the association between dosimetric parameters and toxicities. The receiver operating characteristic (ROC) curve, calibration curve, Akaike\u2019s corrected information criterion (AICc), decision curve analysis (DCA), and clinical impact curve (CIC) were analyzed to evaluate the performance of NTCP models. (3) Results: Bladder V40Gy was identified to develop the NTCP model of AUT, and the mean AUC was 0.69 (CI: 0.58\u20130.80). Three candidate predictors, namely the small intestine V30Gy, colon D45%, and rectum D55%, were identified to develop the NTCP model of ALGIT, and the mean AUC was 0.71 (CI: 0.61\u20130.80). Both models were considered to have relatively good discriminative accuracy and could provide a high net benefit in clinical applications. (4) Conclusions: We developed NTCP models to predict the probability for grade \u2265 2 AUT and ALGIT. We recommend that bladder V40Gy, the small intestine V30Gy, colon D45%, and rectum D55% be controlled below 42%, 20.4%, 16.9 Gy, and 32.0 Gy, respectively.<\/jats:p>","DOI":"10.3390\/curroncol32010026","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T11:24:19Z","timestamp":1735730659000},"page":"26","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting High-Grade Acute Urinary Toxicity and Lower Gastrointestinal Toxicity After Postoperative Volumetric Modulated Arc Therapy for Cervical and Endometrial Cancer Using a Normal Tissue Complication Probability Model"],"prefix":"10.3390","volume":"32","author":[{"given":"Tianyu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhong","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.suronc.2011.12.008","article-title":"Management of recurrent cervical cancer: A review of the literature","volume":"21","author":"Peiretti","year":"2012","journal-title":"Surg. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/cncr.27652","article-title":"The effect of treatment time in locally advanced cervical cancer in the era of concurrent chemoradiotherapy","volume":"119","author":"Song","year":"2013","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/acm2.12003","article-title":"Dosimetric benefits of intensity-modulated radiotherapy and volumetric-modulated arc therapy in the treatment of postoperative cervical cancer patients","volume":"18","author":"Deng","year":"2017","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.ijrobp.2007.08.046","article-title":"The effect of intensity-modulated radiotherapy on radiation-induced second malignancies","volume":"70","author":"Ruben","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1118\/1.2818738","article-title":"Volumetric modulated arc therapy: IMRT in a single gantry arc","volume":"35","author":"Otto","year":"2008","journal-title":"Med. Phys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.radonc.2008.06.013","article-title":"A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy","volume":"89","author":"Cozzi","year":"2008","journal-title":"Radiother. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3892\/ol.2015.3998","article-title":"A comparative dosimetric study of volumetric-modulated arc therapy vs. fixed field intensity-modulated radiotherapy in postoperative irradiation of stage IB-IIA high-risk cervical cancer","volume":"11","author":"Qiao","year":"2016","journal-title":"Oncol. Lett."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000484608","article-title":"Volumetric Modulated Arc Therapy versus Fixed-Field Intensity-Modulated Radiotherapy in Radical Irradiation for Cervical Cancer without Lymphadenectasis: Dosimetric and Clinical Results","volume":"41","author":"Guo","year":"2018","journal-title":"Oncol. Res. Treat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1148\/rg.2020200013","article-title":"2018 FIGO Staging Classification for Cervical Cancer: Added Benefits of Imaging","volume":"40","author":"Salib","year":"2020","journal-title":"Radiographics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijgo.2009.02.010","article-title":"Revised FIGO staging for carcinoma of the endometrium","volume":"105","author":"Creasman","year":"2009","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1056\/NEJM199904153401501","article-title":"Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer","volume":"340","author":"Morris","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1006\/gyno.1999.5387","article-title":"A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: A Gynecologic Oncology Group Study","volume":"73","author":"Sedlis","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.annonc.2022.05.009","article-title":"Endometrial cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"33","author":"Oaknin","year":"2022","journal-title":"Ann. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijrobp.2020.08.061","article-title":"NRG Oncology\/RTOG Consensus Guidelines for Delineation of Clinical Target Volume for Intensity Modulated Pelvic Radiation Therapy in Postoperative Treatment of Endometrial and Cervical Cancer: An Update","volume":"109","author":"Small","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"g7594","DOI":"10.1136\/bmj.g7594","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD statement","volume":"350","author":"Collins","year":"2015","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/S0360-3016(01)02785-7","article-title":"Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies","volume":"52","author":"Mundt","year":"2002","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0360-3016(01)01664-9","article-title":"Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation","volume":"51","author":"Portelance","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.radonc.2003.05.001","article-title":"A dosimetric analysis of acute gastrointestinal toxicity in women receiving intensity-modulated whole-pelvic radiation therapy","volume":"69","author":"Roeske","year":"2003","journal-title":"Radiother. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ijrobp.2011.12.020","article-title":"Postoperative intensity-modulated arc therapy for cervical and endometrial cancer: A prospective report on toxicity","volume":"84","author":"Vandecasteele","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.21037\/tcr-20-2573","article-title":"Extended field or pelvic intensity-modulated radiotherapy with concurrent cisplatin chemotherapy for the treatment of post-surgery multiple pelvic lymph node metastases in cervical cancer patients: A randomized, multi-center phase II clinical trial","volume":"10","author":"Luo","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.ejmp.2016.08.013","article-title":"Bladder spatial-dose descriptors correlate with acute urinary toxicity after radiation therapy for prostate cancer","volume":"32","author":"Improta","year":"2016","journal-title":"Phys. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ijrobp.2018.02.004","article-title":"Risk of late urinary complications following image-guided adaptive brachytherapy for locally advanced cervical cancer: Refining bladder dose-volume parameters","volume":"101","author":"Manea","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.6004\/jnccn.2023.0062","article-title":"NCCN Guidelines\u00ae Insights: Cervical Cancer, Version 1.2024","volume":"21","author":"Yashar","year":"2023","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.6004\/jnccn.2014.0025","article-title":"Uterine neoplasms, version 1.2014","volume":"12","author":"Koh","year":"2014","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13014-015-0486-5","article-title":"Intensity-modulated radiation therapy versus three-dimensional conformal radiation therapy with concurrent nedaplatin-based chemotherapy after radical hysterectomy for uterine cervical cancer: Comparison of outcomes, complications, and dose-volume histogram parameters","volume":"10","author":"Isohashi","year":"2015","journal-title":"Radiat. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.ijrobp.2011.12.012","article-title":"Normal tissue complication probability analysis of acute gastrointestinal toxicity in cervical cancer patients undergoing intensity modulated radiation therapy and concurrent cisplatin","volume":"83","author":"Simpson","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.ijrobp.2009.05.071","article-title":"Radiation dose-volume effects in the stomach and small bowel","volume":"76","author":"Kavanagh","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S1470-2045(16)30120-6","article-title":"Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): An open-label, multicentre, randomized, phase 3 trial","volume":"17","author":"Powell","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0305-7372(03)00117-8","article-title":"Acute and long-term toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer","volume":"29","author":"Maduro","year":"2003","journal-title":"Cancer Treat. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ijrobp.2009.03.078","article-title":"Radiation dose-volume effects in radiation-induced rectal injury","volume":"76","author":"Michalski","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.ijrobp.2005.10.007","article-title":"A modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading","volume":"64","author":"Khalid","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/1\/26\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:23:19Z","timestamp":1759850599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/1\/26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["curroncol32010026"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32010026","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]}}}