{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:37:21Z","timestamp":1759970241263,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Department of Aarau Cantonal Hospital, Aarau, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The objective of this study was to analyze treatment approaches and outcomes according to patients\u2019 perspectives for patients with indeterminate spinal instability caused by neoplastic lesions. Data were collected from 31 patients with a total of 147 spinal neoplastic lesions, 29 of whom had lesions classified as indeterminate. These lesions were divided into two groups: the low indeterminate group (SINS 7\u20139) and the high indeterminate group (SINS 10\u201312). Conservative treatment was the primary approach (93%), resulting in improvement in 59% of cases, stability in 22%, and asymptomatic outcomes in 19%. No significant differences in self-reported outcomes were found between surgical and non-surgical treatments (p = 0.98, p = 0.18). Surgery was reserved for patients with severe pain or impending neurological compromise. Our findings suggest that conservative management is a viable option for most patients with indeterminate spinal instability caused by neoplastic lesions, provided pain and neurological stability are adequately controlled.<\/jats:p>","DOI":"10.3390\/curroncol32010038","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:42:15Z","timestamp":1736750535000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Outcomes in Spinal Tumors According to Patients\u2019 Perspectives: A Focus on Indeterminate Spinal Instability"],"prefix":"10.3390","volume":"32","author":[{"given":"Victoria H.","family":"Schimmelpenning","sequence":"first","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery and Traumatology, Aarau Cantonal Hospital, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Brugger","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery and Traumatology, Aarau Cantonal Hospital, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0311-5009","authenticated-orcid":false,"given":"Nikki","family":"Rommers","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Basel, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6576-0825","authenticated-orcid":false,"given":"Johann","family":"Kunst","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery and Traumatology, Aarau Cantonal Hospital, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery and Traumatology, Aarau Cantonal Hospital, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-3458","authenticated-orcid":false,"given":"Christoph E.","family":"Albers","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology, University Hospital Bern, Inselspital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-0095","authenticated-orcid":false,"given":"Helena","family":"Milavec","sequence":"additional","affiliation":[{"name":"Spine Unit, Department of Orthopaedic Surgery and Traumatology, Aarau Cantonal Hospital, 5001 Aarau, Switzerland"},{"name":"Department of Orthopaedic Surgery and Traumatology, University Hospital Bern, Inselspital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00007632-199001000-00001","article-title":"Spinal Metastases The Obvious, the Occult, and the Impostors","volume":"15","author":"Wong","year":"1990","journal-title":"Spine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100446","DOI":"10.1016\/j.jbo.2022.100446","article-title":"Epidemiology of spinal metastases, metastatic epidural spinal cord compression and pathologic vertebral compression fractures in patients with solid tumors: A systematic review","volume":"35","author":"Peeters","year":"2022","journal-title":"J. Bone Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s00113-021-01052-0","article-title":"Versorgungsstrategien bei pathologischen Frakturen der Wirbels\u00e4ule","volume":"124","author":"Pishnamaz","year":"2021","journal-title":"Unfallchirurg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"101927","DOI":"10.1016\/j.suronc.2023.101927","article-title":"Spinal lesions in multiple myeloma: Primary bone tumors with distinct prognostic factors","volume":"48","author":"Ly","year":"2023","journal-title":"Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.14444\/7112","article-title":"Surgical Management of Multiple Myeloma With Symptomatic Involvement of the Spine","volume":"14","author":"Milavec","year":"2020","journal-title":"Int. J. Spine Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"E1221","DOI":"10.1097\/BRS.0b013e3181e16ae2","article-title":"A Novel Classification System for Spinal Instability in Neoplastic Disease: An Evidence-Based Approach and Expert Consensus From the Spine Oncology Study Group","volume":"35","author":"Fisher","year":"2010","journal-title":"Spine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1634\/theoncologist.2012-0293","article-title":"The NOMS Framework: Approach to the Treatment of Spinal Metastatic Tumors","volume":"18","author":"Laufer","year":"2013","journal-title":"Oncologist"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Milavec, H., Kellner, C., Ravikumar, N., Cristoph, E.A., Lerch, T., Hoppe, S., Deml, M.C., Bigdon, S.F., Kumar, N., and Benneker, L.M. (2019). First Clinical Experience with a Carbon Fibre Reinforced PEEK Composite Plating System for Anterior Cervical Discectomy and Fusion. J. Funct. Biomater., 10.","DOI":"10.20944\/preprints201905.0220.v1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e1034","DOI":"10.1016\/j.wneu.2019.05.067","article-title":"SINS Score and Stability: Evaluating the Need for Stabilization Within the Uncertain Category","volume":"128","author":"Pennington","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lenschow, M., Lenz, M., Von Spreckelsen, N., Ossmann, J., Meyer, J., Ke\u00dfling, J., Nadjiri, L., Telentschak, S., Zarghooni, K., and Kn\u00f6ll, P. (2022). Impact of Spinal Instrumentation on Neurological Outcome in Patients with Intermediate Spinal Instability Neoplastic Score (SINS). Cancers, 14.","DOI":"10.3390\/cancers14092193"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/neuros\/nyx567","article-title":"State of the Art Treatment of Spinal Metastatic Disease","volume":"82","author":"Barzilai","year":"2018","journal-title":"Neurosurgery"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Serratrice, N., Faddoul, J., Tarabay, B., Attieh, C., Chalah, M.A., Ayache, S.S., and Abi Lahoud, G.N. (2022). Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.802595"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.3171\/2021.2.FOCUS201098","article-title":"An analysis of tumor-related potential spinal column instability (Spine Instability Neoplastic Scores 7\u201312) eventually requiring surgery with a 1-year follow-up","volume":"50","author":"Vargas","year":"2021","journal-title":"Neurosurg. Focus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e745","DOI":"10.1016\/j.wneu.2024.06.159","article-title":"The Truly Intermediate Subgroup Within the SINS \u201cPotentially Unstable\u201d Category: The Matryoshka Doll Phenomenon","volume":"189","author":"Mahakul","year":"2024","journal-title":"World Neurosurg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.21037\/atm.2019.01.65","article-title":"Intra- and interobserver reliability of the Spinal Instability Neoplastic Score system for instability in spine metastases: A systematic review and meta-analysis","volume":"7","author":"Pennington","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/21925682211033591","article-title":"Correlation Between the Spinal Instability Neoplastic Score (SINS) and Patient Reported Outcomes","volume":"13","author":"Versteeg","year":"2023","journal-title":"Glob. 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