{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:26:07Z","timestamp":1780496767100,"version":"3.54.1"},"reference-count":16,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Radiation-induced morphea (RIM) is a rare complication following radiotherapy (RT) for breast cancer treatment. Its distribution is usually confined to the breast having received radiotherapy. A generalized form of RIM also exists, defined as lesions extending beyond the radiotherapy site, but data on the subject are scarce in the literature. This complication remains difficult to treat, due partly to the variable extent of disease and to individual clinical response rates to the wide array of available therapies, such as topical therapy (i.e., topical tacrolimus or topical corticosteroids), phototherapy, and systemic therapy (i.e., systemic immunosuppressants). We present a case of extensive morphea post RT for breast cancer with 2 years of favorable evolution under systemic therapy.<\/jats:p>","DOI":"10.3390\/curroncol32010050","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T10:32:15Z","timestamp":1737369135000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Extensive Morphea Following Adjuvant Radiotherapy for Breast Carcinoma\u2014Case Report"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9926-4574","authenticated-orcid":false,"given":"Alexandru","family":"Panaitescu","sequence":"first","affiliation":[{"name":"Radiation Oncology Service, Department of Nuclear Medicine and Radiation Oncology, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4471-2952","authenticated-orcid":false,"given":"Hannah","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8068-4320","authenticated-orcid":false,"given":"Laurence","family":"Masson-C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Radiation Oncology Service, Department of Nuclear Medicine and Radiation Oncology, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5420-5261","authenticated-orcid":false,"given":"Carolina Lucena","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Dermatology Service, Department of Medicine, Faculty of Medicine and Health Sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"ref_1","first-page":"717","article-title":"Morphea and Lichen Sclerosus","volume":"Volume 1","author":"Bolognia","year":"2024","journal-title":"Dermatology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Joly-Chevrier, M., G\u00e9linas, A., Ghazal, S., Moussa, S., McCuaig, C.C., Piram, M., Mereniuk, A., Litvinov, I.V., Osman, M., and Pehr, K. 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