{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:28:00Z","timestamp":1790731680758,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Division of Hematology, Department of Medicine, University of Ottawa"},{"name":"Jazz Pharmaceuticals Canada, Astellas Pharma Canada and Taiho Pharma Canada Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Little is known about patient perspectives regarding consent for obtaining extra research-specific bone marrow (BM) samples during the diagnostic procedure for acute leukemia (AL). This study aimed to better understand patient experiences with consenting to provide these samples and identify potential areas for practice improvement. Semi-structured interviews were conducted with patients treated for AL, 4\u20136 years prior to the interviews, and healthcare professionals involved with obtaining patient consent and sample collection. A total of 17 patients (14 agreed to provide a sample and 3 did not have a sample in the biobank) and 5 healthcare professionals were interviewed, achieving data saturation. Patients supported increasing public knowledge about research and noted the importance of friends and family in providing emotional support and retaining information. Despite time pressure and anxiety, the decision to donate a research sample did not require much deliberation. Proximal factors informing decisions included impact on patient health and family and anticipated, procedure-associated pain; distal factors included altruism and trust in healthcare professionals. Key information included expected pain and management, the purpose of research samples, and sample security and privacy. Our findings suggest that BM research sample collection may be facilitated through optimizing the environment where information is provided and the type of information provided, including pain management options and the value of the samples for current and future research.<\/jats:p>","DOI":"10.3390\/curroncol32030179","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T10:38:48Z","timestamp":1742380728000},"page":"179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient and Healthcare Professional Reflections on Consenting for Extra Bone Marrow Samples to a Biobank for Research\u2014A Qualitative Study"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-9069","authenticated-orcid":false,"given":"Stuart G.","family":"Nicholls","sequence":"first","affiliation":[{"name":"Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Medical School, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn","family":"Chesser","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Davis","sequence":"additional","affiliation":[{"name":"Independent Researcher, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Godard","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Fox","sequence":"additional","affiliation":[{"name":"Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8725-6145","authenticated-orcid":false,"given":"Madeleine Jane","family":"Gordon","sequence":"additional","affiliation":[{"name":"Medical School, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystina B.","family":"Lewis","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Lepage","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Motalo","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Ottawa, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Nuttall","sequence":"additional","affiliation":[{"name":"Independent Researcher, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Peleshok","sequence":"additional","affiliation":[{"name":"Independent Researcher, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caryn Y.","family":"Ito","sequence":"additional","affiliation":[{"name":"The Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"},{"name":"Ottawa Institute of Systems Biology, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-1721","authenticated-orcid":false,"given":"Pierre J. A.","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-6138","authenticated-orcid":false,"given":"Mitchell","family":"Sabloff","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"Wei","year":"2022","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1002\/cncr.34894","article-title":"Systematic review and meta-analysis: Prognostic impact of time from diagnosis to treatment in patients with acute myeloid leukemia","volume":"129","author":"Franco","year":"2023","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/jamaoncol.2024.2662","article-title":"Contemporary Management of Acute Myeloid Leukemia: A Review","volume":"10","author":"Venugopal","year":"2024","journal-title":"JAMA Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Bhatia, K., Sandhu, V., Wong, M.H., Iyer, P., and Bhatt, S. (2024). Therapeutic biomarkers in acute myeloid leukemia: Functional and genomic approaches. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1275251"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Small, S., Oh, T.S., and Platanias, L.C. (2022). Role of Biomarkers in the Management of Acute Myeloid Leukemia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314543"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1158\/2159-8290.CD-17-0841","article-title":"Targeting the MTF2\u2013MDM2 axis sensitizes refractory acute myeloid leukemia to chemotherapy","volume":"8","author":"Maganti","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_7","unstructured":"Snapes, E., De Wilde, A., Carpenter, J., Schacter, B., Simeon-Dubach, D., Tarling, T., Arant, C., Bledsoe, M., Standard, E., and Watson, P. (2023). Best Practices: Recommendations for Repositories, ISBER. [5th ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1503\/cmaj.120565","article-title":"Defining diagnostic tissue in the era of personalized medicine","volume":"185","author":"Cheung","year":"2013","journal-title":"Can. Med. Assoc. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000362648","article-title":"The role of diagnostic tissue in research","volume":"81","author":"Cheung","year":"2014","journal-title":"Pathobiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1634\/theoncologist.2018-0233","article-title":"\u201cAs Long as You Ask\u201d: A Qualitative Study of Biobanking Consent-Oncology Patients\u2019 and Health Care Professionals\u2019 Attitudes, Motivations, and Experiences-the B-PPAE Study","volume":"24","author":"Yip","year":"2019","journal-title":"Oncologist"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/0272989X20936209","article-title":"20th Anniversary Update of the Ottawa Decision Support Framework Part 1: A Systematic Review of the Decisional Needs of People Making Health or Social Decisions","volume":"40","author":"Hoefel","year":"2020","journal-title":"Med. Decis. Mak."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1097\/ACM.0000000000000388","article-title":"Standards for reporting qualitative research: A synthesis of recommendations","volume":"89","author":"Harris","year":"2014","journal-title":"Acad. Med."},{"key":"ref_13","unstructured":"Patton, M.Q. (2002). Qualitative Research and Evaluation Methods, Sage. [3rd ed.]."},{"key":"ref_14","unstructured":"Krueger, R.A., and Casey, M.A. (2000). Focus Groups: A Practical Guide for Applied Research, Sage. [3rd ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lincoln, Y.S., and Guba, E.G. (1985). Naturalistic Inquiry, Sage.","DOI":"10.1016\/0147-1767(85)90062-8"},{"key":"ref_16","unstructured":"Bowling, A. (2004). Research Methods in Health. Investigating Health and Health Services, Open University Press. [2nd ed.]."},{"key":"ref_17","unstructured":"(2024, September 16). NVivo: Leading Qualitative Data Analysis Software (QDAS) by Lumivero n.d. Available online: https:\/\/lumivero.com\/products\/nvivo\/."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/26895269.2022.2129597","article-title":"Toward good practice in thematic analysis: Avoiding common problems and be(com)ing a knowing researcher","volume":"24","author":"Braun","year":"2022","journal-title":"Int. J. Transgend. Health"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Braun, V., Clarke, V., Terry, G., and Hayfield, N. (2019). Thematic Analysis. Handbook of Research Methods in Health Social Sciences, Springer.","DOI":"10.1007\/978-981-10-5251-4_103"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/NCC.0000000000000274","article-title":"Consent to Donate Surgical Biospecimens for Research: Perceptions of People with Colorectal Cancer","volume":"39","author":"Williams","year":"2016","journal-title":"Cancer Nurs."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/bio.2013.0083","article-title":"Cancer patient perceptions about biobanking and preferred timing of consent","volume":"12","author":"Braun","year":"2014","journal-title":"Biopreserv. Biobank"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jnci\/djq498","article-title":"Consent for biobanking: Assessing the understanding and views of cancer patients","volume":"103","author":"Mancini","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejca.2017.10.025","article-title":"Enlisting the willing: A study of healthcare professional-initiated and opt-in biobanking consent reveals improvement opportunities throughout the registration process","volume":"89","author":"Fradgley","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1399-0004.2006.00614.x","article-title":"Views of female breast cancer patients who donated biologic samples regarding storage and use of samples for genetic research","volume":"69","author":"Kaphingst","year":"2006","journal-title":"Clin. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1369-7625.2012.00781.x","article-title":"Contributing to research via biobanks: What it means to cancer patients","volume":"17","author":"Pellegrini","year":"2014","journal-title":"Health Expect."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Domaradzki, J., Czekajewska, J., and Walkowiak, D. (2024). Attitudes of oncology patients\u2019 towards biospecimen donation for biobank research. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12145-5"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/jnci\/djy221","article-title":"Systematic Review and Meta-Analysis of the Magnitude of Structural, Clinical, and Physician and Patient Barriers to Cancer Clinical Trial Participation","volume":"111","author":"Unger","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1053\/j.sempedsurg.2018.10.005","article-title":"Learning health systems","volume":"27","author":"Deans","year":"2018","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Domaradzki, J., and Pawlikowski, J. (2019). Public Attitudes toward Biobanking of Human Biological Material for Research Purposes: A Literature Review. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16122209"},{"key":"ref_30","unstructured":"Morris, T.R. (2019). The Gift Relationship: From Human Blood to Social Policy, Policy Press."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000164216","article-title":"Why might people donate tissue for cancer research? Insights from organ\/tissue\/blood donation and clinical research","volume":"75","author":"Axler","year":"2008","journal-title":"Pathobiology"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Dive, L., Critchley, C., Otlowski, M., Mason, P., Wiersma, M., Light, E., Stewart, C., Kerridge, I., and Lipworth, W. (2020). Public trust and global biobank networks. BMC Med. Ethics, 21.","DOI":"10.1186\/s12910-020-00515-0"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/3\/179\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:56:40Z","timestamp":1760029000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/3\/179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["curroncol32030179"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32030179","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]}}}