{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:07:38Z","timestamp":1760058458393,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Oncological care of adolescent patients is often inconsistent, as they frequently fall between pediatric and adult services. The Childhood Cancer Registry of Campania (CCRC) is the Italian largest population-based registry specializing in children 0\u201319 years old, with a target population of approximately 1.1 million inhabitants. Material and Methods: This report presents epidemiological indicators and clinical pathways on primary brain tumors in adolescents (15\u201319 years) from the Campania region. Results: Over the study period (2008\u20132020), the cohort included 219 adolescents with newly diagnosed central nervous system (CNS) tumors with an annual average incidence rate (IR) of 48.9 cases per million\/year. The 5-year observed survival rate after diagnosis of CNS tumor was 84.8%. Overall, the most common tumor site was the pituitary gland and craniopharyngeal duct, representing 22.4% of all tumors. The most frequently occurring malignant primary CNS tumor was germinoma, while the most common non-malignant tumor was pituitary adenoma. Most patients were referred to adult services and nearly half migrated outside the region to receive cancer care. Conclusions: Challenges in the care of adolescent oncology patients include limited access to specialized care, difficulties in transitioning from pediatric to adult institutions, distinct tumor biology, and the underrepresentation of adolescents in clinical trials. The care of adolescents with CNS tumors is fragmented across institutions and significant variations in practice exist between adult and pediatric practitioners.<\/jats:p>","DOI":"10.3390\/curroncol32040222","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:47:41Z","timestamp":1744282061000},"page":"222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Central Nervous System Tumors in Adolescents: A Population-Based Study on Epidemiology and Clinical Pathways in a Challenging Age Group"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6232-5255","authenticated-orcid":false,"given":"Lucia","family":"De Martino","sequence":"first","affiliation":[{"name":"Neurooncology Unit, Department of Pediatric Oncology, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Piga","sequence":"additional","affiliation":[{"name":"Childhood Cancer Registry of Campania, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-6636","authenticated-orcid":false,"given":"Marcella","family":"Sessa","sequence":"additional","affiliation":[{"name":"Childhood Cancer Registry of Campania, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7228-2399","authenticated-orcid":false,"given":"Camilla","family":"Cal\u00ec","sequence":"additional","affiliation":[{"name":"Childhood Cancer Registry of Campania, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2256-7281","authenticated-orcid":false,"given":"Camilla","family":"Russo","sequence":"additional","affiliation":[{"name":"Pediatric Neuroradiology Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Picariello","sequence":"additional","affiliation":[{"name":"Neurooncology Unit, Department of Pediatric Oncology, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Onorini","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-8605","authenticated-orcid":false,"given":"Pietro","family":"Spennato","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-8979","authenticated-orcid":false,"given":"Lucia","family":"Quaglietta","sequence":"additional","affiliation":[{"name":"Neurooncology Unit, Department of Pediatric Oncology, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Donofrio","sequence":"additional","affiliation":[{"name":"Pathology Unit, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Cinalli","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Unit, Department of Pediatric Neurosciences, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2649-8906","authenticated-orcid":false,"given":"Francesco","family":"Vetrano","sequence":"additional","affiliation":[{"name":"Childhood Cancer Registry of Campania, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7132-0050","authenticated-orcid":false,"given":"Fabio","family":"Savoia","sequence":"additional","affiliation":[{"name":"Childhood Cancer Registry of Campania, Santobono-Pausilipon Children\u2019s Hospital, 80129 Naples, 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