{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:08:31Z","timestamp":1791259711287,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Glioblastoma in patients affected by NF1 germline mutation (NF1-associated GBM) represents a unique heterogeneous clinical and pathological entity. We have reviewed the few cases reported in the literature and they seem to have a better response to standard therapy and overall survival than GBM in the non-NF1 population. We present two cases of long-survival NF1 patients with GBM. Case 1 was a 38-year-old woman with cerebellar GBM who underwent surgical asportation and the Stupp protocol many times with an overall survival of 117 months. Case 2 was a 47-year-old woman with GBM in the eloquent area of the right frontal lobe; she underwent surgical asportation and the Stupp protocol with an overall survival of 25 months. The data analysis demonstrates that NF1-associated GBM patients could be considered long-term survivors.<\/jats:p>","DOI":"10.3390\/curroncol32040242","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:34:36Z","timestamp":1745206476000},"page":"242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glioblastoma in NF1: A Unique Entity\u2014A Literature Review Focusing on Surgical Implication and Our Experience"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8769-3922","authenticated-orcid":false,"given":"Elisa","family":"Garbin","sequence":"first","affiliation":[{"name":"Academic Neurosurgery, Department of Neurosciences, University of Padova, 35128 Padova, PD, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Nicol\u00e8","sequence":"additional","affiliation":[{"name":"Unit of Pathology, Angel Hospital, 30174 Mestre, VE, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7421-6846","authenticated-orcid":false,"given":"Salima","family":"Magrini","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Department of Neurosciences, Angel Hospital, 30174 Mestre, VE, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8479-3674","authenticated-orcid":false,"given":"Yuri","family":"Ceccaroni","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Department of Neurosciences, Angel Hospital, 30174 Mestre, VE, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2529-6149","authenticated-orcid":false,"given":"Luca","family":"Denaro","sequence":"additional","affiliation":[{"name":"Academic Neurosurgery, Department of Neurosciences, University of Padova, 35128 Padova, PD, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Basaldella","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Department of Neurosciences, Angel Hospital, 30174 Mestre, VE, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rossetto","sequence":"additional","affiliation":[{"name":"Unit of Neurosurgery, Department of Neurosciences, Angel Hospital, 30174 Mestre, VE, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00401-022-02478-5","article-title":"Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1","volume":"144","author":"Lucas","year":"2022","journal-title":"Acta Neuropathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jocn.2018.05.002","article-title":"Ten-year survival in glioblastoma. 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