{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:13:52Z","timestamp":1760033632201,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Introduction: Multiple myeloma constitutes approximately 12% of hematologic malignancies and predominantly affects older adults, significantly compromising their quality of life. Although exercise interventions have shown benefits in oncology, evidence specific to MM remains limited and of low certainty. The presence of complex comorbidities in MM patients necessitates highly individualized approaches. Prehabilitation has emerged as a promising strategy to enhance functional capacity prior to autologous stem cell transplantation. This case study evaluates the feasibility of a personalized, scheduled exercise intervention delivered via telerehabilitation. Intervention: This case study seeks to examine the feasibility of implementing a personalized and scheduled exercise intervention within a telerehabilitation framework for a medically complex patient with multiple myeloma (MM). The 12-week prehabilitation protocol is designed to enhance physical function prior to autologous bone marrow transplantation by integrating therapeutic exercise targeting key parameters related to quality of life and clinical resilience, such as muscular strength, aerobic capacity, coordination, and overall well-being. The intervention includes concurrent training (strength and aerobic exercises) delivered 2\u20133 times per week, with aerobic activities conducted independently at home through a virtual format. Assessments were performed at baseline and post-intervention. Results and conclusion: A personalized exercise program, implemented through a hybrid model of in-person and telerehabilitation, is both feasible and safe. It has the potential to enhance physical function and quality of life in patients with multiple myeloma. Further research is necessary to validate these findings across broader patient populations.<\/jats:p>","DOI":"10.3390\/curroncol32050282","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T06:57:28Z","timestamp":1747378648000},"page":"282","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a Concurrent Mixed-Modality (Telerehabilitation and Face-to-Face) Exercise Rehabilitation Program in a Patient with Multiple Myeloma Prior to Spinal Cord Transplantation: A Case Study"],"prefix":"10.3390","volume":"32","author":[{"given":"Juan Carlos","family":"Hern\u00e1ndez-Sig\u00fcenza","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2656-6307","authenticated-orcid":false,"given":"Paula","family":"Blanco-Gimenez","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-1706","authenticated-orcid":false,"given":"Luis","family":"Baraja-Vegas","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"L\u00f3pez-Soler","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-4393","authenticated-orcid":false,"given":"Francisco Javier","family":"Falaguera-Vera","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-3444","authenticated-orcid":false,"given":"Eloy","family":"Jaenada-Carrilero","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-2931","authenticated-orcid":false,"given":"Juan","family":"Vicente-Mampel","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Health Sciences School, Catholic University of Valencia, 46001 Torrent,  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102279","DOI":"10.1016\/j.ejon.2023.102279","article-title":"Feasibility and efficacy of telerehabilitation in the management of patients with head and neck cancer during and after oncological treatment: A systematic review","volume":"63","year":"2023","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41408-022-00643-3","article-title":"Extramedullary disease in multiple myeloma: A systematic literature review","volume":"12","author":"Beksac","year":"2022","journal-title":"Blood Cancer J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Scott, K., Hayden, P.J., Will, A., Wheatley, K., and Coyne, I. (2013). Bortezomib for the treatment of multiple myeloma. Cochrane Database Syst. Rev., CD010816.","DOI":"10.1002\/14651858.CD010816"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41408-022-00779-2","article-title":"The prevalence and outcomes of frail older adults in clinical trials in multiple myeloma: A systematic review","volume":"13","author":"Mian","year":"2023","journal-title":"Blood Cancer J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/hon.2552","article-title":"Frontline treatment for trans-plant-eligible multiple myeloma: A 6474 patients network meta-analysis","volume":"37","author":"Sekine","year":"2019","journal-title":"Hematol. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00008469-200506000-00002","article-title":"The data quality of haematological malignancy ICD-10 diagnoses in a population-based Hospital Discharge Registry","volume":"14","author":"Skriver","year":"2005","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.clml.2022.10.003","article-title":"Safety, Feasibility, and Efficacy of Exercise In-terventions for People with Multiple Myeloma: A Systematic Review","volume":"23","author":"Nicol","year":"2023","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_8","first-page":"1637","article-title":"Impact+ resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: A randomized controlled trial","volume":"24","author":"Dobek","year":"2012","journal-title":"Osteoporos. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","article-title":"Sarcopenia as a Determinant of Chemotherapy Toxicity and Time to Tumor Progression in Metastatic Breast Cancer Patients Receiving Capecitabine Treatment","volume":"15","author":"Prado","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_10","first-page":"CD013259","article-title":"Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery","volume":"5","author":"Molenaar","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1002\/cam4.4021","article-title":"Prehabilitation exercise therapy for cancer: A systematic review and meta-analysis","volume":"10","author":"Michael","year":"2021","journal-title":"Cancer Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.anclin.2014.11.002","article-title":"Prehabilitation to enhance perioperative care","volume":"33","author":"Carli","year":"2015","journal-title":"Anesthesiol. Clin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/jamasurg.2018.1645","article-title":"Effect of Exercise and Nutrition Prehabilitation on Functional Capacity in Esophagogastric Cancer Surgery: A Randomized Clinical Trial","volume":"153","author":"Minnella","year":"2018","journal-title":"JAMA Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1007\/s10238-023-01058-5","article-title":"The effect of exercise interventions on quality of life in patients with multiple myeloma: A systematic review and meta-analysis of randomised controlled trials","volume":"23","author":"Goodhew","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1177\/0884533614551969","article-title":"Physical activity and cancer survivorship","volume":"29","author":"Garcia","year":"2014","journal-title":"Nutr. Clin. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1188\/08.ONF.E53-E61","article-title":"Effects of Exercise in Combination with Epoetin Alfa During High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma","volume":"35","author":"Coleman","year":"2008","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_17","first-page":"132","article-title":"Declaration of Helsinki","volume":"59","author":"Duncan","year":"2013","journal-title":"World Med. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/j.jbi.2016.09.006","article-title":"Checking the lists: A systematic review of electronic checklist use in health care","volume":"71","author":"Kramer","year":"2017","journal-title":"J. Biomed. Inform."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lee, S.-C., Wu, L.-C., Chiang, S.-L., Lu, L.-H., Chen, C.-Y., Lin, C.-H., Ni, C.-H., and Lin, C.-H. (2020). Validating the Capability for Measuring Age-Related Changes in Grip-Force Strength Using a Digital Hand-Held Dynamometer in Healthy Young and Elderly Adults. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/6936879"},{"key":"ref_20","first-page":"1768","article-title":"Measurement of hand grip strength: A cross-sectional study of two dynamometry devices","volume":"78","author":"Fourie","year":"2022","journal-title":"S. Afr. J. Physiother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/HCR.0000000000000336","article-title":"1-Minute Sit-to-Stand Test: Systematic Review of Procedures, Performance, and Clinimetric Properties","volume":"39","author":"Bohannon","year":"2019","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1097\/PHM.0000000000002504","article-title":"Which Sit-to-Stand Test Best Differentiates Functional Capacity in Older People?","volume":"103","author":"Valencia","year":"2024","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1440-2440(05)80025-8","article-title":"Reliability and validity of physical fitness field tests for adults aged 55 to 70 years","volume":"8","author":"Ritchie","year":"2005","journal-title":"J. Sci. Med. Sport"},{"key":"ref_24","unstructured":"Miranda, N., and Tiu, T.K. (2025, May 13). Berg Balance Testing, StatPearls [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK574518\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1519\/JSC.0b013e31825c32a8","article-title":"Intrarater Reliability of the Functional Movement Screen","volume":"27","author":"Gribble","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ross, R.M., Murthy, J.N., Wollak, I.D., and Jackson, A.S. (2010). The six minute walk test accurately estimates mean peak oxygen uptake. BMC Pulm. Med., 10.","DOI":"10.1186\/1471-2466-10-31"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1534735420918935","DOI":"10.1177\/1534735420918935","article-title":"Feasibility and Effects of a Supervised Exercise Program Suitable for Independent Training at Home on Physical Function and Quality of Life in Head and Neck Cancer Patients: A Pilot Study","volume":"19","author":"Felser","year":"2020","journal-title":"Integr. Cancer Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1055\/s-0032-1323746","article-title":"Validity of the Six-Minute Walk Test in Cancer Patients","volume":"34","author":"Schmidt","year":"2013","journal-title":"Int. J. Sport Med."},{"key":"ref_29","unstructured":"Ware, J., Kosinski, M., and Gandek, B. (1993). SF-36 Health Survey: Manual & Interpretation Guide, Linc RI Qual Inc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1157\/13074369","article-title":"El Cuestionario de Salud SF-36 espa\u00f1ol: Una d\u00e9cada de experiencia y nuevos desarrollos","volume":"19","author":"Vilagut","year":"2005","journal-title":"Gac. Sanit."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1097\/00007632-200012150-00008","article-title":"SF-36 Health Survey Update","volume":"25","author":"Ware","year":"2000","journal-title":"Spine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2050312116671725","DOI":"10.1177\/2050312116671725","article-title":"SF-36 total score as a single measure of health-related quality of life: Scoping review","volume":"4","author":"Lins","year":"2016","journal-title":"SAGE Open Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1136\/bmj.305.6846.160","article-title":"Validating the SF-36 health survey questionnaire: New outcome measure for primary care","volume":"305","author":"Brazier","year":"1992","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10549-012-2212-4","article-title":"The Piper Fatigue Scale-12 (PFS-12): Psychometric findings and item reduction in a cohort of breast cancer survivors","volume":"136","author":"Reeve","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejon.2017.02.005","article-title":"The importance of self-care for fatigue amongst patients undergoing chemotherapy for primary cancer","volume":"28","author":"Hegarty","year":"2017","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_36","unstructured":"PhD Dgpgo (2025, May 13). Functional Movement Screen (FMS) a la Palestra: \u00bfQu\u00e9 nos dice la Ciencia?\u2014Grupo Sobre Entrenamiento. Available online: https:\/\/g-se.com\/es\/functional-movement-screen-fms-a-la-palestra-que-nos-dice-la-ciencia."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"262","DOI":"10.21859\/sija.12.3.262","article-title":"Comparing the Quality of Life Between Active and Non-Active Elderly Women with an Emphasis on Physical Activity","volume":"12","author":"Ahmadi","year":"2017","journal-title":"Salmand"},{"key":"ref_38","first-page":"47","article-title":"Use of a functional movement screening tool to determine injury risk in female collegiate athletes","volume":"5","author":"Chorba","year":"2010","journal-title":"N. Am. J. Sports Phys. Ther. NAJSPT"},{"key":"ref_39","first-page":"147","article-title":"Can Serious Injury in Professional Football be Predicted by a Preseason Functional Move-ment Screen?","volume":"2","author":"Kiesel","year":"2007","journal-title":"N. Am. J. Sports Phys. Ther. NAJSPT"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/00002820-200310000-00012","article-title":"Feasibility of exercise during treatment for multiple myeloma","volume":"26","author":"Coleman","year":"2003","journal-title":"Cancer Nurs."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.6004\/jadpro.2023.14.2.5","article-title":"Physical Activity in Multiple Myeloma: A Review of the Current Literature","volume":"14","author":"Hillengass","year":"2023","journal-title":"J. Adv. Pract. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/5\/282\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:33:48Z","timestamp":1760031228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/5\/282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["curroncol32050282"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32050282","relation":{},"ISSN":["1718-7729"],"issn-type":[{"type":"electronic","value":"1718-7729"}],"subject":[],"published":{"date-parts":[[2025,5,16]]}}}