{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:36:23Z","timestamp":1782948983284,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: This study aimed to investigate the effects of allogeneic hematopoietic stem cell transplantation (HSCT) on quality of life and behavioral problems in children diagnosed with leukemia and \u03b2-thalassemia major, with a focus on post-transplant diagnosis-specific differences in psychosocial adjustment. Method: This study included 112 children (63 children with acute leukemia, 49 children with \u03b2-thalassemia major) aged 6\u201318 years, along with a control group of 30 healthy children within the same age range. The Pediatric Quality of Life Inventory (PedsQL) and the Child Behavior Checklist for Ages 6\u201318 (CBCL) were administered. Participants were categorized into five groups, and the outcomes were compared accordingly. Results: The emotional functioning subscale scores of the PedsQL were significantly lower in children with leukemia and those who had undergone HSCT for leukemia, when compared to children with thalassemia (p &lt; 0.05). The social functioning subscale scores were also significantly lower in children with leukemia who underwent HSCT compared to those with thalassemia (p &lt; 0.05). The CBCL internalizing scores were higher in children with leukemia and post-HSCT leukemia patients than in their healthy peers (p &lt; 0.05). Over time, both diagnostic groups showed improvements, with total PedsQL scores increasing and total CBCL scores decreasing after HSCT. Conclusions: This study demonstrates that quality of life improved and behavioral problems diminished over time following HSCT. However, the psychosocial impact of HSCT varied depending on the underlying disease, with children diagnosed with leukemia being slightly more adversely affected. These findings suggest that interventions aimed at improving quality of life and addressing behavioral issues should be tailored to the specific diagnosis.<\/jats:p>","DOI":"10.3390\/curroncol32060311","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T06:30:26Z","timestamp":1748413826000},"page":"311","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impacts of Hematopoietic Stem Cell Transplantation on Quality of Life and Behavioral Outcomes in Pediatric Patients with Leukemia and Thalassemia"],"prefix":"10.3390","volume":"32","author":[{"given":"Aysun","family":"Kara Uzun","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Ankara 06018, Turkey"},{"name":"Division of Social Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay Y\u0131ld\u0131z","family":"Akku\u015f","sequence":"additional","affiliation":[{"name":"Child Development Unit, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u00e7a","family":"Koca Yozgat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Ankara 06018, Turkey"},{"name":"Department of Pediatric Hematology, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadime","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Ankara 06018, Turkey"},{"name":"Division of Social Pediatrics, Department of Pediatrics, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Arman Bilir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Ankara 06018, Turkey"},{"name":"Department of Pediatric Hematology, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcsniye Ne\u015fe","family":"Yaral\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"},{"name":"Department of Pediatrics, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06010, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam\u0131k Ya\u015far","family":"\u00d6zbek","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Ankara 06018, Turkey"},{"name":"Department of Pediatric Hematology, Children\u2019s Hospital, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/canjclin.50.1.7","article-title":"Cancer Statistics","volume":"50","author":"Greenlee","year":"2000","journal-title":"Cancer J. 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