{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:57:58Z","timestamp":1793055478102,"version":"4.5.0"},"reference-count":85,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012279","name":"Zhejiang Provincial Xinmiao Talents Program","doi-asserted-by":"publisher","award":["2023R41045"],"award-info":[{"award-number":["2023R41045"]}],"id":[{"id":"10.13039\/501100012279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012279","name":"Zhejiang Provincial Xinmiao Talents Program","doi-asserted-by":"publisher","award":["82204979"],"award-info":[{"award-number":["82204979"]}],"id":[{"id":"10.13039\/501100012279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012279","name":"Zhejiang Provincial Xinmiao Talents Program","doi-asserted-by":"publisher","award":["2023ZR085"],"award-info":[{"award-number":["2023ZR085"]}],"id":[{"id":"10.13039\/501100012279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023R41045"],"award-info":[{"award-number":["2023R41045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204979"],"award-info":[{"award-number":["82204979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023ZR085"],"award-info":[{"award-number":["2023ZR085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023R41045"],"award-info":[{"award-number":["2023R41045"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["82204979"],"award-info":[{"award-number":["82204979"]}]},{"name":"Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project","award":["2023ZR085"],"award-info":[{"award-number":["2023ZR085"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Platinum-based chemotherapy significantly increases the risk of nausea and vomiting, which can impair the treatment\u2019s efficacy and the patient\u2019s quality of life. This meta-analysis examines the incidence and risk factors of platinum-based chemotherapy-induced nausea and vomiting (PINV) in patients treated with this chemotherapy. Methods: This systematic review and meta-analysis were conducted in accordance with the PRISMA 2020 guidelines. We conducted a literature search in the databases PubMed, Embase, Web of Science, WanFang, China Science and Technology Journal Database (VIP), China National Knowledge Infrastructure (CNKI), and Chinese Medical Association Journal Database (CMAJD) through to 20 January 2025. Studies that reported the incidence and identified risk factors of nausea and vomiting specifically in patients receiving platinum-based chemotherapy were included in the review. The data were extracted independently by two reviewers. The odds ratios (ORs) for each risk factor were calculated from the included studies. Sensitivity analyses and additional subgroup analyses were performed to ensure the robustness of our findings. Results: This meta-analysis included 32 studies involving 14,207 participants. Female sex (OR = 2.363, 95% CI = 1.363\u20134.096, p = 0.002), anxiety (OR = 1.689, 95% CI = 1.057\u20132.700, p = 0.028), fatigue (OR = 1.413, 95% CI = 1.145\u20131.744, p = 0.001), motion sickness (OR = 1.816, 95% CI = 1.266\u20132.605, p = 0.001), and a history of vomiting during chemotherapy (OR = 2.728, 95% CI = 1.468\u20135.069, p = 0.002) were significantly associated with an increased risk of PINV. Conclusion: Female sex, anxiety, fatigue, motion sickness, and a history of vomiting during chemotherapy increase the risk of PINV during platinum-based treatments.<\/jats:p>","DOI":"10.3390\/curroncol32060325","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:34:13Z","timestamp":1748853253000},"page":"325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence and Risk Factors of Platinum-Based Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2510-5647","authenticated-orcid":false,"given":"Kaili","family":"Jin","sequence":"first","affiliation":[{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Oncology, Dingqiao Branch of GuangXing Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-3408","authenticated-orcid":false,"given":"Qiuhua","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing, Zhejiang Chinese Medical University, Hangzhou 310053, China"},{"name":"Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102195","DOI":"10.1016\/j.esmoop.2023.102195","article-title":"2023 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting","volume":"9","author":"Herrstedt","year":"2024","journal-title":"ESMO Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/nure.12016","article-title":"Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: A systematic literature review","volume":"71","author":"Marx","year":"2013","journal-title":"Nutr. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pearce, A., Haas, M., Viney, R., Pearson, S.A., Haywood, P., Brown, C., and Ward, R. (2017). Incidence and severity of self-reported chemotherapy side effects in routine care: A prospective cohort study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184360"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R219","DOI":"10.1530\/ERC-15-0237","article-title":"The state-of-play and future of platinum drugs","volume":"22","author":"Apps","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2021692","DOI":"10.1001\/jamanetworkopen.2020.21692","article-title":"Activity of Platinum-Based Chemotherapy in Patients with Advanced Prostate Cancer with and without DNA Repair Gene Aberrations","volume":"3","author":"Schmid","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1039\/C8DT00838H","article-title":"The side effects of platinum-based chemotherapy drugs: A review for chemists","volume":"47","author":"Oun","year":"2018","journal-title":"Dalton Trans."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2165\/00002018-199513040-00003","article-title":"Comparative adverse effect profiles of platinum drugs","volume":"13","author":"McKeage","year":"1995","journal-title":"Drug Saf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1200\/JCO-24-01308","article-title":"Randomized, Phase III Trial of Mixed Formulation of Fosrolapitant and Palonosetron (HR20013) in Preventing Cisplatin-Based Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: PROFIT","volume":"43","author":"Zhou","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ning, C., Yan, Y., Wang, Y., Li, R., Liu, W., Qiu, L., Sun, L., and Yang, Y. (2024). Research trends on chemotherapy induced nausea and vomiting: A bibliometric analysis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1369442"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00520-004-0745-8","article-title":"Anticipatory nausea and vomiting","volume":"13","author":"Aapro","year":"2005","journal-title":"Support. Care Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s005200050157","article-title":"Methodology of antiemetic trials: Response assessment, evaluation of new agents and definition of chemotherapy emetogenicity","volume":"6","author":"Hesketh","year":"1998","journal-title":"Support. Care Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s005200100295","article-title":"Delayed emesis: Incidence, pattern, prognostic factors and optimal treatment","volume":"10","author":"Roila","year":"2002","journal-title":"Support. Care Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.jand.2015.10.020","article-title":"Chemotherapy-Induced Nausea and Vomiting: A Narrative Review to Inform Dietetics Practice","volume":"116","author":"Marx","year":"2016","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.cmet.2020.10.023","article-title":"GDF-15 neutralization alleviates platinum-based chemotherapy-induced emesis, anorexia, and weight loss in mice and nonhuman primates","volume":"32","author":"Breen","year":"2020","journal-title":"Cell Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1200\/JCO.20.01296","article-title":"Antiemetics: ASCO guideline update","volume":"38","author":"Hesketh","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_16","first-page":"S259","article-title":"Overview of chemotherapy-induced nausea and vomiting and evidence-based therapies","volume":"23","author":"Adel","year":"2017","journal-title":"Am. J. Manag. Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1200\/JOP.2010.000151","article-title":"Prevalence of Delayed Nausea and\/or Vomiting in Patients Treated With Oxaliplatin-Based Regimens for Colorectal Cancer","volume":"8","author":"Fleishman","year":"2012","journal-title":"J. Oncol. Pract."},{"key":"ref_18","first-page":"1505","article-title":"Genetic risk factors for chemotherapy-induced nausea and vomiting in patients with cancer receiving cisplatin-based chemotherapy","volume":"26","author":"Yokoi","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jpainsymman.2013.05.003","article-title":"Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Patients Receiving Highly or Moderately Emetogenic Chemotherapy: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"47","author":"Mizukami","year":"2014","journal-title":"J. Pain Symptom Manag."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"O\u2019Sullivan, B., Brierley, J., D\u2019Cruz, A., Fey, M., Pollock, R.E., Vermorken, J., and Huang, S.H. (2015). UICC Manual of Clinical Oncology, Wiley Online Library.","DOI":"10.1002\/9781119013143"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/ajcn\/48.3.888","article-title":"NCI dietary guidelines: Rationale","volume":"48","author":"Butrum","year":"1988","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_22","first-page":"219","article-title":"The joanna briggs institute critical appraisal tools for use in systematic review: Prevalence study and analytical cross sectional study","volume":"33","author":"Zhou","year":"2018","journal-title":"J. Nurses Train."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"ref_24","first-page":"380","article-title":"Meta-Analysis of Censored Adverse Events","volume":"2","author":"Qi","year":"2024","journal-title":"N. Engl. J. Stat. Data Sci."},{"key":"ref_25","unstructured":"Zhou, Z., Tian, Z., Peterson, C.B., Bao, L., and Zhou, S. (2024). Shiny-MAGEC: A Bayesian R Shiny Application for Meta-analysis of Censored Adverse Events. arXiv."},{"key":"ref_26","first-page":"209","article-title":"Logistic regression analysis of risk factors associated with nausea and vomiting","volume":"26","author":"Min","year":"2011","journal-title":"Qilu Med. J."},{"key":"ref_27","first-page":"157","article-title":"Analysis of the Impact of Nausea and Vomiting on Patients with Malignant Tumors Undergoing Chemotherapy","volume":"33","author":"Zhang","year":"2011","journal-title":"Fujian J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/NNR.0b013e3182691438","article-title":"Antiemetic effectiveness and nausea and vomiting incidence during capecitabine and oxaliplatin chemotherapy","volume":"61","author":"Chan","year":"2012","journal-title":"Nurs. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00520-010-1073-9","article-title":"Chemotherapy-induced nausea and vomiting in daily clinical practice: A community hospital-based study","volume":"20","author":"Hilarius","year":"2012","journal-title":"Support. Care Cancer"},{"key":"ref_30","first-page":"105","article-title":"Logistic control study on factors related to nausea and vomiting in patients with lung cancer after chemotherapy","volume":"18","author":"Huajun","year":"2012","journal-title":"Contemp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/pds.3516","article-title":"Impact of cancer-related fatigue on chemotherapy-induced nausea and vomiting in Asian cancer patients","volume":"22","author":"Poon","year":"2013","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_32","first-page":"10","article-title":"Risk factors of chemotherapy-induced nausea and vomiting in cancer patients","volume":"32","author":"Jiao","year":"2015","journal-title":"PLA Nurs. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2476","DOI":"10.1097\/MD.0000000000002476","article-title":"Personalized Estimate of Chemotherapy-Induced Nausea and Vomiting: Development and External Validation of a Nomogram in Cancer Patients Receiving Highly\/Moderately Emetogenic Chemotherapy","volume":"95","author":"Hu","year":"2016","journal-title":"Medicine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1248\/bpb.b16-00440","article-title":"An Analysis of Behavioral and Genetic Risk Factors for Chemotherapy-Induced Nausea and Vomiting in Japanese Subjects","volume":"39","author":"Mukoyama","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref_35","first-page":"1","article-title":"Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: A prospective registration study by the CINV Study Group of Japan","volume":"30","author":"Baba","year":"2017","journal-title":"Dis. Esophagus"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/imj.13428","article-title":"Relationship between Helicobacter pylori infection and vomiting induced by gastrointestinal cancer chemotherapy","volume":"47","author":"Yao","year":"2017","journal-title":"Intern. Med. J."},{"key":"ref_37","first-page":"2770","article-title":"Analysis of high risk factors for nausea and vomiting induced by chemotherapy","volume":"19","author":"Limin","year":"2019","journal-title":"Chinese Medicine and Clinical Practice."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Meissner, K., Talsky, N., Olliges, E., Jacob, C., St\u00f6tzer, O.J., Salat, C., Braun, M., and Flondor, R. (2019). Individual Factors Contributing to Nausea in First-Time Chemotherapy Patients: A Prospective Cohort Study. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00410"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00520-018-4403-y","article-title":"Risk factors associated with chemotherapy-induced nausea and vomiting in the triplet antiemetic regimen including palonosetron or granisetron for cisplatin-based chemotherapy: Analysis of a randomized, double-blind controlled trial","volume":"27","author":"Tsuji","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Yoshida, N., Taguchi, T., Nakanishi, M., Inoue, K., Okayama, T., Ishikawa, T., Otsuji, E., Takayama, K., Kuroboshi, H., and Kanazawa, M. (2019). Efficacy of the combination use of aprepitant and palonosetron for improving nausea in various moderately emetogenic chemotherapy regimens. BMC Pharmacol. Toxicol., 20.","DOI":"10.1186\/s40360-018-0278-2"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1007\/s00520-020-05377-1","article-title":"Chemotherapy-induced nausea in a sample of gynaecological cancer patients: Assessment issues and personal risk factors evaluation","volume":"28","author":"Carnelli","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.clinthera.2020.08.007","article-title":"Patient-related Risk Factors for Nausea and Vomiting With Standard Antiemetics in Patients With Cancer Receiving Carboplatin: A Retrospective Study","volume":"42","author":"Nasu","year":"2020","journal-title":"Clin. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.11606\/s1518-8787.2020054002178","article-title":"Risk factors associated with antineoplastic chemotherapy-induced nausea and vomiting","volume":"54","author":"Simino","year":"2020","journal-title":"Rev. Sa\u00fade P\u00fablica"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00384-020-03731-7","article-title":"Risk factors of chemotherapy-induced nausea and vomiting in patients with metastatic colorectal cancer: A prospective cohort study (YCOG1301)","volume":"35","author":"Takei","year":"2020","journal-title":"Int. J. Color. Dis."},{"key":"ref_45","first-page":"2541","article-title":"Influencing factors and nursing measures of nausea and vomiting in patients with malignant tumor undergoing chemotherapy","volume":"39","author":"Zou","year":"2020","journal-title":"Int. J. Nurs."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4103\/apjon.apjon-2120","article-title":"Chemotherapy-Induced Nausea and Vomiting in Breast Cancer Patients: A Multicenter Prospective Observational Study","volume":"8","author":"Huang","year":"2021","journal-title":"Asia-Pac. J. Oncol. Nurs."},{"key":"ref_47","unstructured":"Huijie, Z. (2021). A Real-World Survey of Chemotherapy-Related Nausea and Vomiting in Cancer Patients and Analysis of Risk Factors. [Master\u2019s Thesis, Sichuan University]."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Shimokawa, M., Hayashi, T., Nishimura, J., Satoh, T., Fukunaga, M., Matsui, R., Tsuji, Y., Mizuki, F., and Kogawa, T. (2021). Pooled analysis of combination antiemetic therapy for chemotherapy-induced nausea and vomiting in patients with colorectal cancer treated with oxaliplatin-based chemotherapy of moderate emetic risk. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08860-y"},{"key":"ref_49","first-page":"1384","article-title":"Construction of a predictive model for the risk of chemotherapy-associated nausea and vomiting","volume":"22","author":"Deng","year":"2022","journal-title":"China Nurs. Manag."},{"key":"ref_50","first-page":"1176","article-title":"Gender differences in risk factors for chemotherapy-related nausea and vomiting","volume":"20","author":"Bo","year":"2022","journal-title":"Cent. South Pharm."},{"key":"ref_51","first-page":"505","article-title":"Logistic regression analysis of risk factors associated with nausea and vomiting","volume":"45","author":"Zhe","year":"2022","journal-title":"J. Xinjiang Med. Univ."},{"key":"ref_52","first-page":"e44438","article-title":"Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer: Risk Factor and Predictive Model Using Classification and Regression Tree (CART)","volume":"15","author":"Ng","year":"2023","journal-title":"Cureus"},{"key":"ref_53","first-page":"346","article-title":"Analysis of influencing factors of chemotherapy-related nausea and vomiting and construction of nomogram model","volume":"6","author":"Yuqing","year":"2023","journal-title":"Med. High. Vocat. Educ. Mod. Nurs."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cac2.12397","article-title":"Validation of different personalized risk models of chemotherapy-induced nausea and vomiting: Results of a randomized, double-blind, phase III trial of fosaprepitant for cancer patients treated with high-dose cisplatin","volume":"43","author":"Zhao","year":"2023","journal-title":"Cancer Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e2426076","DOI":"10.1001\/jamanetworkopen.2024.26076","article-title":"Olanzapine as Antiemetic Prophylaxis in Moderately Emetogenic Chemotherapy: A Phase 3 Randomized Clinical Trial","volume":"7","author":"Ostwal","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_56","first-page":"142","article-title":"Analysis on the Occurrence of Vomiting during Chemotherapy and Its Influencing Factors in Patients with Breast Cancer","volume":"21","author":"Wei","year":"2024","journal-title":"Med. Innov. China"},{"key":"ref_57","first-page":"713","article-title":"Update on the management of chemotherapy-induced nausea and vomiting\u2014focus on palonosetron","volume":"11","author":"Zhou","year":"2015","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1007\/s12325-023-02537-7","article-title":"Real-World Treatment Outcomes, Healthcare Resource Use, and Costs Associated with Antiemetics Among Cancer Patients on Cisplatin-Based Chemotherapy","volume":"40","author":"Navari","year":"2023","journal-title":"Adv. Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"943","DOI":"10.2217\/pgs.10.67","article-title":"Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy","volume":"11","author":"Hammer","year":"2010","journal-title":"Pharmacogenomics"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.chom.2022.03.030","article-title":"High-fat diet disrupts REG3\u03b3 and gut microbial rhythms promoting metabolic dysfunction","volume":"30","author":"Frazier","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jpainsymman.2013.06.012","article-title":"Evaluation of risk factors predicting chemotherapy-related nausea and vomiting: Results from a European prospective observational study","volume":"47","author":"Molassiotis","year":"2014","journal-title":"J. Pain Symptom Manag."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4143\/crt.2014.045","article-title":"Cisplatin-Based Chemotherapy is a Strong Risk Factor for Thromboembolic Events in Small-Cell Lung Cancer","volume":"47","author":"Lee","year":"2015","journal-title":"Cancer Res. Treat."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra0706547","article-title":"Chemotherapy-induced nausea and vomiting","volume":"358","author":"Hesketh","year":"2008","journal-title":"New Engl. J. Med."},{"key":"ref_64","first-page":"481","article-title":"Chinese Guidelines for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting in Antitumor Therapy (2023 Edition)","volume":"46","author":"Zhang","year":"2024","journal-title":"Chin. J. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Chic, N., Schettini, F., Bras\u00f3-Maristany, F., Sanfeliu, E., Adamo, B., Vidal, M., Mart\u00ednez, D., Galv\u00e1n, P., Gonz\u00e1lez-Farr\u00e9, B., and Cort\u00e9s, J. (2021). Oestrogen receptor activity in hormone-dependent breast cancer during chemotherapy. EBioMedicine, 69.","DOI":"10.1016\/j.ebiom.2021.103451"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00520-005-0914-4","article-title":"Combined data from two phase III trials of the NK 1 antagonist aprepitant plus a 5HT 3 antagonist and a corticosteroid for prevention of chemotherapy-induced nausea and vomiting: Effect of gender on treatment response","volume":"14","author":"Hesketh","year":"2006","journal-title":"Support. Care Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1207\/s15324796abm3301_8","article-title":"Anticipatory nausea: The role of individual differences related to sensory perception and autonomic reactivity","volume":"33","author":"Mehlsen","year":"2007","journal-title":"Ann. Behav. Med."},{"key":"ref_68","first-page":"256","article-title":"The pathophysiology of treatment-related nausea and vomiting in cancer patients: Current models","volume":"48","author":"Shelke","year":"2004","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00001610-200511000-00003","article-title":"The pathophysiology of chemotherapy-induced nausea and vomiting","volume":"28","author":"Baker","year":"2005","journal-title":"Gastroenterol. Nurs."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"McRonald, F.E., and Fleisher, D.R. (2005). Anticipatory nausea in cyclical vomiting. BMC Pediatr., 5.","DOI":"10.1186\/1471-2431-5-3"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"101213","DOI":"10.1016\/j.ctcp.2020.101213","article-title":"The effect of breathing exercise on nausea, vomiting and functional status in breast cancer patients undergoing chemotherapy","volume":"40","author":"Aybar","year":"2020","journal-title":"Complement. Ther. Clin. Pract."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00520-001-0329-9","article-title":"The effectiveness of progressive muscle relaxation training in managing chemotherapy-induced nausea and vomiting in Chinese breast cancer patients: A randomised controlled trial","volume":"10","author":"Molassiotis","year":"2002","journal-title":"Support. Care Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3959(92)90049-H","article-title":"Hypnosis or cognitive behavioral training for the reduction of pain and nausea during cancer treatment: A controlled clinical trial","volume":"48","author":"Syrjala","year":"1992","journal-title":"Pain"},{"key":"ref_74","first-page":"95","article-title":"Psychological interventions in chemotherapy-induced nausea and vomiting in women with breast cancer: A systematic review","volume":"47","author":"Samami","year":"2022","journal-title":"Iran. J. Med. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e13604","DOI":"10.1111\/nmo.13604","article-title":"Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association","volume":"31","author":"Venkatesan","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/0269216311406991","article-title":"The relationship between interleukin-6, tumor necrosis factor-\u03b1, and fatigue in terminally ill cancer patients","volume":"26","author":"Kwak","year":"2012","journal-title":"Palliat. Med."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Meneses-Ech\u00e1vez, J.F., Gonz\u00e1lez-Jim\u00e9nez, E., and Ram\u00edrez-V\u00e9lez, R. (2015). Effects of supervised multimodal exercise interventions on cancer-related fatigue: Systematic review and meta-analysis of randomized controlled trials. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/328636"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2152\/jmi.67.338","article-title":"Effects of chemotherapy on quality of life and night-time sleep of colon cancer patients","volume":"67","author":"Yoshikawa","year":"2020","journal-title":"J. Med. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Hosseini Koukamari, P., Karimy, M., Ghaffari, M., and Milajerdi, A. (2025). Effect of cognitive-behavioral therapy on fatigue in cancer patients: A systematic review and meta-analysis. Front. Psychol., 15.","DOI":"10.3389\/fpsyg.2024.1435110"},{"key":"ref_80","first-page":"11","article-title":"A receptor-based paradigm of nausea and vomiting","volume":"1","author":"Smith","year":"2005","journal-title":"J. Cancer Pain Symptom Palliation"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00520-019-05012-8","article-title":"Revisiting the physiology of nausea and vomiting\u2014Challenging the paradigm","volume":"28","author":"Wickham","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Zhong, W., Shahbaz, O., Teskey, G., Beever, A., Kachour, N., Venketaraman, V., and Darmani, N.A. (2021). Mechanisms of nausea and vomiting: Current knowledge and recent advances in intracellular emetic signaling systems. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115797"},{"key":"ref_83","first-page":"304","article-title":"Chinese expert consensus on the management of clinical pathway and adverse events of trastuzumab deruxtecan (2024 edition)","volume":"46","author":"Wang","year":"2024","journal-title":"Chin. J. Oncol."},{"key":"ref_84","unstructured":"Hesketh, P.J., Drews, R.E., and Vora, S.R. (2025, May 10). Prevention of Chemotherapy-Induced Nausea and Vomiting in Adults. Available online: https:\/\/www.uptodate.com\/contents\/prevention-of-chemotherapy-induced-nausea-and-vomiting-in-adults."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"V119","DOI":"10.1093\/annonc\/mdw270","article-title":"2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients","volume":"27","author":"Roila","year":"2016","journal-title":"Ann. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/6\/325\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:44:56Z","timestamp":1760031896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/6\/325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":85,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["curroncol32060325"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32060325","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,31]]}}}