{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:15:08Z","timestamp":1779938108490,"version":"3.53.1"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Cystic mucinous neoplasms (MCNs) of the pancreas are rare cystic tumors, accounting for approximately 2\u20135% of all pancreatic neoplasms. They predominantly occur in premenopausal women and are typically located in the body or tail of the pancreas. Due to their potential for malignant transformation, especially in cases associated with invasive carcinoma such as pancreatic ductal adenocarcinoma, early detection, complete surgical resection, and rigorous postoperative surveillance are essential. The occurrence of MCNs in male patients is exceedingly rare, comprising only about 2% of reported cases, and often resulting in preoperative diagnostic challenges. Molecular analyses have identified a strong association between KRAS mutations and disease progression in MCNs, underscoring their potential role as prognostic markers despite limited diagnostic utility. In this report, we present two additional cases of MCNs in male patients, highlighting their histopathological features and the ancillary investigations undertaken to support diagnosis.<\/jats:p>","DOI":"10.3390\/curroncol32060352","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:51:24Z","timestamp":1749808284000},"page":"352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mucinous Cystic Neoplasms in Male Patients: Histopathological and Molecular Diagnoses"],"prefix":"10.3390","volume":"32","author":[{"given":"Lara","family":"Malaspina","sequence":"first","affiliation":[{"name":"Pathology Unit, Ospedale Civico di Carrara, 54033 Carrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5426-5985","authenticated-orcid":false,"given":"Natale","family":"Calomino","sequence":"additional","affiliation":[{"name":"Unit of General Surgery and Kidney Transplantation, Department of Surgery, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-6788","authenticated-orcid":false,"given":"Ludovico","family":"Carbone","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology, Department of Medicine Surgery and Neurosciences, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Batsikosta","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Department of Medical Biotechnology, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Rossi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Ospedale Misericordia di Grosseto, 58100 Grosseto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-2414","authenticated-orcid":false,"given":"Gianmario Edoardo","family":"Poto","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology, Department of Medicine Surgery and Neurosciences, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Visani","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology, Department of Medicine Surgery and Neurosciences, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Mundo","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Department of Medical Biotechnology, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Barbato","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Department of Medical Biotechnology, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Monteleone","sequence":"additional","affiliation":[{"name":"Unit of Diagnostic Imaging, Department of Medicine, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-1259","authenticated-orcid":false,"given":"Franco","family":"Roviello","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology, Department of Medicine Surgery and Neurosciences, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-4730","authenticated-orcid":false,"given":"Sergio Antonio","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Oncology, Siena University Hospital, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s004280050154","article-title":"A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors","volume":"432","author":"Wouters","year":"1998","journal-title":"Virchows Arch."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12957-023-03145-z","article-title":"Clinical characteristics and survival prediction of surgical patients with invasive pancreatic cystic neoplasm: A large retrospective study over two decades","volume":"21","author":"Song","year":"2023","journal-title":"World J. 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