{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:24:55Z","timestamp":1760059495486,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Standard of Care (SOC) for locally advanced cervical cancer is represented by external beam radiation therapy concurrent with platinum-based chemotherapy and immunotherapy (cCIRT) followed by brachytherapy boost and immunotherapy maintenance. In some instances, it is impossible to perform brachytherapy due to patient and\/or cancer issues. In these circumstances, an external beam boost could be delivered. Using a robotic arm LINAC, it is mandatory to use intramucosal implanted fiducials which are needed for tumour tracking. To avoid invasive procedures, we developed an original intravaginal 3D-printed universal device containing gold fiducials embedded within it. In this paper, we describe the step-by-step procedure that allowed us to obtain the utility model patent, including the in vivo test (feasibility, reproducibility, device compliance) on seven patients within the study protocol \u201cSTereotActic Radiotherapy Boost in locally Advanced Cervical carcinoma patientS\u201d (STARBACS).<\/jats:p>","DOI":"10.3390\/curroncol32060354","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T06:40:27Z","timestamp":1750056027000},"page":"354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and Development of a Device (Sifilotto\u00ae) for Tumour Tracking in Cervical Cancer Patients Undergoing Robotic Arm LINAC Stereotactic Body Radiation Therapy Boost: Background to the STARBACS Study"],"prefix":"10.3390","volume":"32","author":[{"given":"Silvana","family":"Parisi","sequence":"first","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-2369","authenticated-orcid":false,"given":"Giacomo","family":"Ferrantelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"},{"name":"Department of Discipline Chirurgiche, Oncologiche e Stomatologiche (Di.Chir.On.S.), PhD School \u201cPrecision Medicine\u201d, University of Palermo, Piazza Marina 61, 90133 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Santacaterina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"},{"name":"SDOU Radiation Oncology, University Hospital \u201cPapardo\u201d, Contrada Papardo, 98158 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1278-2313","authenticated-orcid":false,"given":"Elvio Grazioso","family":"Russi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Chillari","sequence":"additional","affiliation":[{"name":"Radiotherapy Unit, \u201cVilla Santa Teresa Diagnostica Per Immagini e Radioterapia\u201d, Viale Ing. G. Bagnera 14, 90011 Bagheria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Brogna","sequence":"additional","affiliation":[{"name":"\u201cD.A.I Servizi\u201d Department, COU Medical Physics, University Hospital \u201cAOU G. Martino\u201d, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Siragusa","sequence":"additional","affiliation":[{"name":"\u201cD.A.I Servizi\u201d Department, COU Medical Physics, University Hospital \u201cAOU G. Martino\u201d, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1165-8494","authenticated-orcid":false,"given":"Miriam","family":"Sciacca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-6779","authenticated-orcid":false,"given":"Antonio","family":"Pontoriero","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6287-2806","authenticated-orcid":false,"given":"Giuseppe","family":"Iat\u00ec","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"},{"name":"Department of Clinical and Experimental Medicine (DIMED), University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4696-7634","authenticated-orcid":false,"given":"Stefano","family":"Pergolizzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Dental and Morphological and Functional Imaging (BIOMORF), Residency School of Radiation Oncology, University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA. 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Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(24)01438-7","article-title":"Induction Chemotherapy Followed by Standard Chemoradiotherapy versus Standard Chemoradiotherapy Alone in Patients with Locally Advanced Cervical Cancer (GCIG INTERLACE): An International, Multicentre, Randomised Phase 3 Trial","volume":"404","author":"McCormack","year":"2024","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s11604-023-01510-2","article-title":"Locally Advanced Squamous Cervical Carcinoma (M0): Management and Emerging Therapeutic Options in the Precision Radiotherapy Era","volume":"42","author":"Parisi","year":"2024","journal-title":"Jpn. J. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/jjco\/hyz074","article-title":"Determining the Recommended Dose of Stereotactic Body Radiotherapy Boost in Patients with Cervical Cancer Who Are Unsuitable for Intracavitary Brachytherapy: A Phase I Dose-Escalation Study","volume":"49","author":"Ito","year":"2019","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.carbpol.2018.11.077","article-title":"Current Advances and Future Perspectives of 3D Printing Natural-Derived Biopolymers","volume":"207","author":"Liu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1021\/acsami.6b11793","article-title":"3D Printing Biocompatible Polyurethane\/Poly(Lactic Acid)\/Graphene Oxide Nanocomposites: Anisotropic Properties","volume":"9","author":"Chen","year":"2017","journal-title":"ACS Appl. Mater. 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Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.radonc.2021.08.020","article-title":"Risk Factors for Nodal Failure after Radiochemotherapy and Image Guided Brachytherapy in Locally Advanced Cervical Cancer: An EMBRACE Analysis","volume":"163","author":"Peters","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S1470-2045(20)30753-1","article-title":"MRI-Guided Adaptive Brachytherapy in Locally Advanced Cervical Cancer (EMBRACE-I): A Multicentre Prospective Cohort Study","volume":"22","author":"Tanderup","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s43154-021-00072-3","article-title":"Robotic Systems in Radiotherapy and Radiosurgery","volume":"3","author":"Gerlach","year":"2022","journal-title":"Curr. Robot. 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