{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:39:00Z","timestamp":1790087940999,"version":"4.0.1"},"reference-count":33,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province, China","award":["2022ZQNZD008"],"award-info":[{"award-number":["2022ZQNZD008"]}]},{"name":"Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province, China","award":["2022YNG04"],"award-info":[{"award-number":["2022YNG04"]}]},{"name":"Major Scientific Research Program for Young and Middle-aged Health Professionals of Fujian Province, China","award":["2022Y2015"],"award-info":[{"award-number":["2022Y2015"]}]},{"name":"High-level Talents Training Project of Fujian Cancer Hospital","award":["2022ZQNZD008"],"award-info":[{"award-number":["2022ZQNZD008"]}]},{"name":"High-level Talents Training Project of Fujian Cancer Hospital","award":["2022YNG04"],"award-info":[{"award-number":["2022YNG04"]}]},{"name":"High-level Talents Training Project of Fujian Cancer Hospital","award":["2022Y2015"],"award-info":[{"award-number":["2022Y2015"]}]},{"name":"Clinical Research Center for Precision Treatment of Gynecological Malignancies of Fujian Province","award":["2022ZQNZD008"],"award-info":[{"award-number":["2022ZQNZD008"]}]},{"name":"Clinical Research Center for Precision Treatment of Gynecological Malignancies of Fujian Province","award":["2022YNG04"],"award-info":[{"award-number":["2022YNG04"]}]},{"name":"Clinical Research Center for Precision Treatment of Gynecological Malignancies of Fujian Province","award":["2022Y2015"],"award-info":[{"award-number":["2022Y2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Aims:This study aimed to identify the prognostic value of tumor invasion distance (TID) based on MRI findings in cervical-cancer (CC) patients treated with radiotherapy (RT). Methods: A total of 218 CC patients diagnosed at Fujian Cancer Hospital from December 2018 to December 2019 were included in the study. Cox regression analyses were conducted to identify independent prognostic factors for overall survival (OS), including low 1\/3 vaginal involvement, a longer TID, and RT without chemotherapy. These factors were subsequently used to construct a nomogram for individualized risk prediction. Kaplan\u2013Meier survival analysis was employed to evaluate survival outcomes and establish a risk stratification system. The performance of the new stratification was assessed using the linear trend \u03c72 test, Akaike information criterion, and Harrell\u2019s concordance index. Results: A longer TID was associated with worse 3-year OS (p &lt; 0.001, HR: 3.42, 95% CI: 1.67\u20137.00). A longer TID, lower 1\/3 vaginal involvement, and concurrent chemotherapy were independent prognostic survival factors for CC patients. Compared with the 2018 FIGO staging system, the new risk stratification system provided better monotonicity with a higher linear trend \u03c72 value (28.03 vs. 9.35), better discriminatory ability with smaller Akaike information criterion (312 vs. 331), and a greater Harrell C statistic (0.74 vs. 0.65) for predicting 3-year OS. Conclusions: This was the first study to demonstrate the prognostic value of TID in CC patients who received RT. The new risk stratification system based on TID could complement the 2018 FIGO staging system in identifying high-risk patients for more intense treatment and care. Further prospective research with larger samples is warranted to confirm the significance of TID for CC patients treated with RT.<\/jats:p>","DOI":"10.3390\/curroncol32060355","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:51:22Z","timestamp":1750067482000},"page":"355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tumor Invasion Distance Based on MRI Is a Novel Prognostic Indicator for I-IIIB Cervical Cancer Patients Treated with Radiotherapy"],"prefix":"10.3390","volume":"32","author":[{"given":"Linying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4506-3478","authenticated-orcid":false,"given":"Ning","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2376-1619","authenticated-orcid":false,"given":"Xuefen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuma Road, Fuzhou 350014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/S2214-109X(22)00501-0","article-title":"Global estimates of incidence and mortality of cervical cancer in 2020: A baseline analysis of the WHO Global Cervical Cancer Elimination Initiative","volume":"11","author":"Singh","year":"2023","journal-title":"Lancet Glob. 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