{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:02:09Z","timestamp":1787497329285,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Objective: This study compares the surgical and oncological outcomes of minimally invasive robotic (RLP) and laparoscopic (LLP) left pancreatectomy in pancreatic cancer (PC) patients. Methods: Data from patients who underwent minimally invasive left pancreatectomy between 2013 and 2023 were analyzed. Two groups were identified: RLP and LLP. Perioperative outcomes were compared, including operative time, blood loss, conversion rate, and postoperative complications. Oncological outcomes included margin status, lymph node retrieval, lymph node status, overall survival (OS), and disease-free survival (DFS). Results: Fifty-four patients were divided into the LLP (n = 39) and RLP (n = 15) groups. The median operative time was shorter for LLP than RLP [260 min vs. 366 min, p = 0.007]. Blood loss and conversion rates were comparable (p &gt; 0.05). In the LLP group, significantly more lymph nodes were harvested (29 vs. 19, p = 0.05), and a higher percentage of positive lymph nodes was noted (72% vs. 40%, p = 0.033). No significant difference was found in the R0 resection status (82% vs. 73%, p = 0.358). After a median follow-up of 26 months, OS (23 months vs. 34 months, p = 0.812) and DFS (17 months vs. 16 months, p = 0.635) were similar. Conclusion: RLP provides outcomes identical to LLP in treating body\u2013tail pancreatic cancer, with further studies needed to confirm its long-term oncological efficacy.<\/jats:p>","DOI":"10.3390\/curroncol32070376","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T12:10:31Z","timestamp":1751285431000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical and Oncological Outcomes of Minimally Invasive Left Pancreatectomy for Pancreatic Cancer: Robotic vs. Laparoscopic Approach"],"prefix":"10.3390","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-4357","authenticated-orcid":false,"given":"Matteo","family":"De Pastena","sequence":"first","affiliation":[{"name":"Pancreatic Surgery Unit, University of Verona Hospital Trust, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4635-3680","authenticated-orcid":false,"given":"Gabriella","family":"Lionetto","sequence":"additional","affiliation":[{"name":"University of Verona, 37129 Verona, Italy"},{"name":"Pancreatic Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6893-8618","authenticated-orcid":false,"given":"Salvatore","family":"Paiella","sequence":"additional","affiliation":[{"name":"University of Verona, 37129 Verona, Italy"},{"name":"Pancreatic Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Maruccio","sequence":"additional","affiliation":[{"name":"Pancreatic Surgery Unit, University of Verona Hospital Trust, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5172-2819","authenticated-orcid":false,"given":"Federico","family":"Faustini","sequence":"additional","affiliation":[{"name":"Pancreatic Surgery Unit, University of Verona Hospital Trust, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Venturini","sequence":"additional","affiliation":[{"name":"University of Verona, 37129 Verona, Italy"},{"name":"Pancreatic Surgery Unit, Department of Engineering for Innovation Medicine (DIMI), University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pea","sequence":"additional","affiliation":[{"name":"University of Verona, 37129 Verona, Italy"},{"name":"Pancreatic Surgery Unit, Department of Engineering for Innovation Medicine (DIMI), University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Casciani","sequence":"additional","affiliation":[{"name":"Pancreatic Surgery Unit, University of Verona Hospital Trust, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Malleo","sequence":"additional","affiliation":[{"name":"University of Verona, 37129 Verona, Italy"},{"name":"Pancreatic Surgery Unit, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-2311","authenticated-orcid":false,"given":"Alessandro","family":"Esposito","sequence":"additional","affiliation":[{"name":"Pancreatic Surgery Unit, University of Verona Hospital Trust, 37129 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/SLA.0000000000002979","article-title":"Minimally Invasive Versus Open Distal Pancreatectomy (LEOPARD): A Multicenter Patient-Blinded Randomized Controlled Trial","volume":"269","author":"Boerma","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0000000000003590","article-title":"The Miami International Evidence-Based Guidelines on Minimally Invasive Pancreas Resection","volume":"271","author":"Asbun","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/bjs.11554","article-title":"Comparison of the Duration of Hospital Stay after Laparoscopic or Open Distal Pancreatectomy: Randomized Controlled Trial","volume":"107","author":"Larsson","year":"2020","journal-title":"Br. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.hpb.2020.10.022","article-title":"Minimally Invasive versus Open Distal Pancreatectomy: An Individual Patient Data Meta-Analysis of Two Randomized Controlled Trials","volume":"23","author":"Korrel","year":"2021","journal-title":"HPB"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jhbp.902","article-title":"Surgical Approaches for Minimally Invasive Distal Pancreatectomy: A Systematic Review","volume":"29","author":"Ban","year":"2022","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/jamasurg.2023.2279","article-title":"Learning Curves of Minimally Invasive Distal Pancreatectomy in Experienced Pancreatic Centers","volume":"158","author":"Lof","year":"2023","journal-title":"JAMA Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jhbp.1122","article-title":"Minimally Invasive Distal Pancreatectomy: Chronologic Changes in the Trends and Clinical Outcomes through a 15-Year, Single-Center Experience with 2212 Patients","volume":"29","author":"Park","year":"2022","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1007\/s00464-025-11686-5","article-title":"Robotic Distal Pancreatectomy Using the Warshaw Technique Demonstrated Superior Short-Term Prognosis Compared to the Laparoscopic Approach: Propensity-Matched Cohort Study","volume":"39","author":"Zhou","year":"2025","journal-title":"Surg. Endosc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/SLA.0000000000002561","article-title":"Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA): A Pan-European Propensity Score Matched Study","volume":"269","author":"Klompmaker","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100673","DOI":"10.1016\/j.lanepe.2023.100673","article-title":"Minimally Invasive versus Open Distal Pancreatectomy for Resectable Pancreatic Cancer (DIPLOMA): An International Randomised Non-Inferiority Trial","volume":"31","author":"Korrel","year":"2023","journal-title":"Lancet Reg. Health Eur."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Feng, Q., Jiang, C., Feng, X., Du, Y., Liao, W., Jin, H., Liao, M., Zeng, Y., and Huang, J. (2021). Robotic Versus Laparoscopic Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.752236"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.hbpd.2022.06.001","article-title":"Robotic versus Laparoscopic Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma: A Propensity Score-Matched Analysis","volume":"22","author":"Shin","year":"2023","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Diaz, A., Hays, S., and Hogg, M.E. (2025). The Landmark Series: Minimally Invasive Pancreatic Resection for Ductal Adenocarcinoma, Updates, Trends, and Future Considerations. Ann. Surg. Oncol.","DOI":"10.1245\/s10434-025-17483-7"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1007\/s00464-024-11147-5","article-title":"Comparing Oncologic and Surgical Outcomes of Robotic and Laparoscopic Distal Pancreatectomy: A Propensity-Matched Analysis","volume":"38","author":"Chang","year":"2024","journal-title":"Surg. Endosc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1245\/s10434-022-13054-2","article-title":"Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer: An International, Retrospective, Cohort Study","volume":"30","author":"Chen","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.gtc.2024.07.003","article-title":"Updates in the Surgical Management of Pancreatic Ductal Adenocarcinoma","volume":"54","author":"Harrison","year":"2025","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2596","DOI":"10.1002\/rcs.2596","article-title":"Robotic versus Laparoscopic Distal Pancreatectomy for Pancreatic Adenocarcinoma in Obese Patients","volume":"20","author":"Ausania","year":"2023","journal-title":"Int. J. Med. Robot."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1007\/s00268-021-06216-y","article-title":"Robotic Dual-Console Distal Pancreatectomy: Could It Be Considered a Safe Approach and Surgical Teaching Even in Pancreatic Surgery? A Retrospective Observational Study Cohort","volume":"45","author":"Salvia","year":"2021","journal-title":"World J. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1007\/s00464-021-08724-3","article-title":"A Randomized Controlled Trial of Stapled versus Ultrasonic Transection in Distal Pancreatectomy","volume":"36","author":"Landoni","year":"2021","journal-title":"Surg. Endosc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.surg.2014.02.001","article-title":"Borderline Resectable Pancreatic Cancer: A Consensus Statement by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"155","author":"Bockhorn","year":"2014","journal-title":"Surgery"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of Surgical Complications","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.surg.2016.11.014","article-title":"The 2016 Update of the International Study Group (ISGPS) Definition and Grading of Postoperative Pancreatic Fistula: 11 Years After","volume":"161","author":"Bassi","year":"2017","journal-title":"Surgery"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","article-title":"Delayed Gastric Emptying (DGE) after Pancreatic Surgery: A Suggested Definition by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.surg.2007.02.001","article-title":"Postpancreatectomy Hemorrhage (PPH): An International Study Group of Pancreatic Surgery (ISGPS) Definition","volume":"142","author":"Wente","year":"2007","journal-title":"Surgery"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00464-017-5633-7","article-title":"Laparoscopic Distal Pancreatectomy for Pancreatic Cancer Is Safe and Effective","volume":"32","author":"Bauman","year":"2018","journal-title":"Surg. Endosc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jso.25170","article-title":"Oncologic Outcomes after Robot-Assisted versus Laparoscopic Distal Pancreatectomy: Analysis of the National Cancer Database","volume":"118","author":"Raoof","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhou, J.-Y., Xin, C., Mou, Y.-P., Xu, X.-W., Zhang, M.-Z., Zhou, Y.-C., Lu, C., and Chen, R.-G. (2016). Robotic versus Laparoscopic Distal Pancreatectomy: A Meta-Analysis of Short-Term Outcomes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151189"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13304-020-00715-8","article-title":"Resection or Repair of Large Peripancreatic Arteries during Robotic Pancreatectomy","volume":"72","author":"Kauffmann","year":"2020","journal-title":"Updates Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e409","DOI":"10.1097\/AS9.0000000000000409","article-title":"Robotic Versus Open Pancreatoduodenectomy With Vein Resection and Reconstruction: A Propensity Score-Matched Analysis","volume":"5","author":"Napoli","year":"2024","journal-title":"Ann. Surg. Open"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1089\/lap.2023.0231","article-title":"A Comparison of Robotic Versus Laparoscopic Distal Pancreatectomy for Benign or Malignant Lesions: A Meta-Analysis","volume":"33","author":"Liu","year":"2023","journal-title":"J. Laparoendosc. Adv. Surg. Tech. A"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.hpb.2016.04.008","article-title":"Robotic versus Laparoscopic Distal Pancreatectomy\u2014The First Meta-Analysis","volume":"18","author":"Gavriilidis","year":"2016","journal-title":"HPB"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1007\/s00464-020-07528-1","article-title":"Cost-Effectiveness and Quality of Life Analysis of Laparoscopic and Robotic Distal Pancreatectomy: A Propensity Score-Matched Study","volume":"35","author":"Esposito","year":"2021","journal-title":"Surg. Endosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1007\/s00464-024-10849-0","article-title":"Nationwide Cost-Effectiveness and Quality of Life Analysis of Minimally Invasive Distal Pancreatectomy","volume":"38","author":"Esposito","year":"2024","journal-title":"Surg. Endosc."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/7\/376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:01:03Z","timestamp":1760032863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/7\/376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["curroncol32070376"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32070376","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]}}}