{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:26:05Z","timestamp":1792430765816,"version":"4.5.0"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Quality of life (QoL) is a critical indicator in assessing the success of oncological treatments for head and neck malignancies, reflecting their impact on physiological functions and psychosocial well-being beyond mere survival. Treatments (surgery, radiotherapy, chemotherapy) pose multiple functional and emotional challenges, and recent advancements underscore the necessity of evaluating post-treatment QoL. Objective: This literature review investigates the impact of oncological treatment on the QoL of patients with malignant head and neck cancers (oral, oropharyngeal, hypopharyngeal, laryngeal) and identifies factors influencing their QoL index. Methodology: Using a PICO framework, studies from PubMed Central were analyzed, selected based on inclusion (English publications, full text, PROM results) and exclusion criteria. The last research was conducted on 6 April 2025. From 231 identified studies, 49 were included after applying filters (MeSH: \u201cQuality of Life,\u201d \u201claryngeal cancer,\u201d \u201coral cavity cancer,\u201d etc.). Data were organized in Excel, and the methodology adhered to PRISMA standards. Results: Treatment Impact: Oncological treatments significantly affect QoL, with acute post-treatment declines in functions such as speech, swallowing, and emotional well-being (anxiety, depression). Partial recovery depends on rehabilitative interventions. Influencing Factors: Treatment type, disease stage, socioeconomic, and demographic contexts influence QoL. De-escalated treatments and prompt rehabilitation improve recovery, while complications like trismus, dysphagia, or persistent hearing issues reduce long-term QoL. Assessment Tools: Standardized PROM questionnaires (EORTC QLQ-C30, QLQ-H&amp;N35, MDADI, HADS) highlighted QoL variations. Studies from Europe, North America, and Asia indicate regional differences in outcomes. Limitations: Retrospective designs, small sample sizes, and PROM variability limit generalizability. Multicentric studies with extended follow-up are recommended. Conclusions: Oncological treatments for head and neck malignancies have a complex impact on QoL, necessitating personalized and multidisciplinary strategies. De-escalated therapies, early rehabilitation, and continuous monitoring are essential for optimizing functional and psychosocial outcomes. Methodological gaps highlight the need for standardized research.<\/jats:p>","DOI":"10.3390\/curroncol32070379","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T12:10:31Z","timestamp":1751285431000},"page":"379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Impact of Oncological Treatment on Quality of Life in Patients with Head and Neck Malignancies: A Systematic Literature Review (2020\u20132025)"],"prefix":"10.3390","volume":"32","author":[{"given":"Raluca","family":"Grigore","sequence":"first","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Otorhinolaryngology Department, \u201cCol\u021bea\u201d Clinical Hospital, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Luiza","family":"Bejenaru","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Simona","family":"Berte\u0219teanu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Otorhinolaryngology Department, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra Ioana","family":"Nedelcu-Stancalie","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora Elena","family":"Schipor-Diaconu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona Andreea","family":"Rujan","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0209-9230","authenticated-orcid":false,"given":"Bianca Petra","family":"Taher","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218erban Vifor Gabriel","family":"Berte\u0219teanu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Otorhinolaryngology Department, \u201cCol\u021bea\u201d Clinical Hospital, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Otorhinolaryngology Department, \u201cCol\u021bea\u201d Clinical Hospital, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina Doini\u021ba","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Otorhinolaryngology Department, \u201cCol\u021bea\u201d Clinical Hospital, 030171 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Nicolaescu","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4331-7688","authenticated-orcid":false,"given":"Anca Ionela","family":"C\u00eerstea","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catrinel Beatrice","family":"Simion-Antonie","sequence":"additional","affiliation":[{"name":"Department 12-Otorhynolaryngology, Ophthalmology, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1113S","DOI":"10.1177\/0145561320937627","article-title":"Feasibility of Free Flap Reconstruction Following Salvage Robotic-Assisted Resection of Recurrent and Residual Oropharyngeal Cancer in 3 Patients","volume":"100","author":"Williamson","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijrobp.2022.05.047","article-title":"Long-Term Toxic Effects, Swallow Function, and Quality of Life on MC1273: A Phase 2 Study of Dose De-escalation for Adjuvant Chemoradiation in Human Papillomavirus-Positive Oropharyngeal Cancer","volume":"114","author":"Price","year":"2022","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/cam4.4931","article-title":"Association of hearing loss and tinnitus symptoms with health-related quality of life among long-term oropharyngeal cancer survivors","volume":"12","author":"Aggarwal","year":"2023","journal-title":"Cancer Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/lary.29857","article-title":"Health-Related Quality of Life, Dysphagia, Voice Problems, Depression, and Anxiety After Total Laryngectomy","volume":"132","author":"Wulff","year":"2022","journal-title":"Laryngoscope"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jfma.2024.01.022","article-title":"Impact of pretreatment quality of life on tolerance and survival outcome in head and neck cancer patients undergoing definitive CCRT","volume":"123","author":"Hung","year":"2024","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1007\/s00520-020-05932-w","article-title":"The course of health-related quality of life from diagnosis to two years follow-up in patients with oropharyngeal cancer: Does HPV status matter?","volume":"29","author":"Korsten","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.31557\/APJCP.2020.21.5.1227","article-title":"The Impact of Surgery and Radiotherapy on Health-Related Quality of Life of Individuals with Oral and Oropharyngeal Carcinoma and Short-Term Follow up after Treatment","volume":"21","author":"Goiato","year":"2020","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yifru, T.A., Kisa, S., Dinegde, N.G., and Atnafu, N.T. (2021). Dysphagia and its impact on the quality of life of head and neck cancer patients: Institution-based cross-sectional study. BMC Res. Notes, 14.","DOI":"10.1186\/s13104-020-05440-4"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.14639\/0392-100X-N1992","article-title":"Voice outcomes in patients with advanced laryngeal and hypopharyngeal cancer treated with chemo-radiotherapy","volume":"42","author":"Llorente","year":"2022","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/lary.30410","article-title":"Dysphagia and QoL 3\u2009Years After Treatment of Oropharyngeal Cancer With TORS or Radiotherapy","volume":"133","author":"Scott","year":"2023","journal-title":"Laryngoscope"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s00405-023-08416-9","article-title":"Analysis of swallowing and voice-related quality of life in patients after supracricoid partial laryngectomy","volume":"281","author":"Liu","year":"2024","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cocuzza, S., Maniaci, A., Grillo, C., Ferlito, S., Spinato, G., Coco, S., Merlino, F., Stilo, G., Santoro, G.P., and Iannella, G. (2020). Voice-Related Quality of Life in Post-Laryngectomy Rehabilitation: Tracheoesophageal Fistula\u2019s Wellness. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17124605"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/14015439.2019.1711163","article-title":"Speech handicap index: Cross-cultural adaptation and validation in European Portuguese speakers with oral and oropharyngeal cancer","volume":"46","author":"Sousa","year":"2021","journal-title":"Logop. Phoniatr. Vocol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/1460-6984.12766","article-title":"Development of a holistic communication score (HoCoS) in patients treated for oral or oropharyngeal cancer: Preliminary validation","volume":"58","author":"Balaguer","year":"2023","journal-title":"Int. J. Lang. Commun. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/pon.5803","article-title":"Psychosocial outcomes of human papillomavirus (HPV)- and non-HPV-related head and neck cancers: A longitudinal study","volume":"31","author":"Henry","year":"2022","journal-title":"Psychooncology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102384","DOI":"10.1016\/j.ejon.2023.102384","article-title":"Factors associated with quality of life among patients with a newly diagnosed oral cavity and oropharyngeal cancer","volume":"66","author":"Andersen","year":"2023","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Atula, M., Atula, T., Aro, K., Irjala, H., Halme, E., Jouppila-M\u00e4tt\u00f6, A., Koivunen, P., Wilkman, T., M\u00e4kitie, A., and Elovainio, M. (2024). Psychosocial factors and patient and healthcare delays in large (class T3-T4) oral, oropharyngeal, and laryngeal carcinomas. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12517-x"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9936715","DOI":"10.1155\/2021\/9936715","article-title":"Evaluation of Malnutrition and Quality of Life in Patients Treated for Oral and Oropharyngeal Cancer","volume":"2021","author":"Pingili","year":"2021","journal-title":"Sci. World J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lam-Ubol, A., Sukhaboon, J., Rasio, W., Tupwongse, P., Tangshewinsirikul, T., and Trachootham, D. (2023). Nutri-PEITC Jelly Significantly Improves Progression-Free Survival and Quality of Life in Patients with Advanced Oral and Oropharyngeal Cancer: A Blinded Randomized Placebo-Controlled Trial. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097824"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.ejso.2022.01.017","article-title":"A prospective longitudinal study of quality of life in robotic-assisted salvage surgery for oropharyngeal cancer","volume":"48","author":"Bordenave","year":"2022","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"NP319","DOI":"10.1177\/01455613221098784","article-title":"Efficacy of Larynx Preservation Surgery and Multimodal Adjuvant Therapy for Hypopharyngeal Cancer: A Case Series Study","volume":"102","author":"Li","year":"2023","journal-title":"Ear Nose Throat J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S1470-2045(23)00265-6","article-title":"Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): A phase 3, multicentre, randomised, controlled trial","volume":"24","author":"Nutting","year":"2023","journal-title":"Lancet Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s00520-020-05630-7","article-title":"Self-Reported Trismus: Prevalence, severity and impact on quality of life in oropharyngeal cancer survivorship: A cross-sectional survey report from a comprehensive cancer center","volume":"29","author":"Cardoso","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105510","DOI":"10.1016\/j.oraloncology.2021.105510","article-title":"Effect of elective neck dissection versus sentinel lymph node biopsy on shoulder morbidity and health-related quality of life in patients with oral cavity cancer: A longitudinal comparative cohort study","volume":"122","author":"Sancak","year":"2021","journal-title":"Oral Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"105574","DOI":"10.1016\/j.oraloncology.2021.105574","article-title":"factors associated with patient-reported quality of life outcomes after free flap reconstruction of the oral cavity","volume":"123","author":"Jimenez","year":"2021","journal-title":"Oral Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.suronc.2020.08.014","article-title":"Oral and oropharyngeal cancer surgery with free-flap reconstruction in the elderly: Factors associated with long-term quality of life, patient needs and concerns. A GETTEC cross-sectional study","volume":"35","author":"Bozec","year":"2020","journal-title":"Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000512085","article-title":"Patient-Reported Outcomes of Split-Thickness Skin Grafts for Floor of Mouth Cancer Reconstruction","volume":"83","author":"Larson","year":"2021","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e20231146","DOI":"10.1590\/1806-9282.20231146","article-title":"Evolution of the quality of life of total laryngectomy patients using electrolarynx","volume":"70","author":"Monte","year":"2024","journal-title":"Rev. Assoc. Med. Bras."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12955-020-1281-z","article-title":"Quality of life after total laryngectomy: Impact of different vocal rehabilitation methods in a middle income country","volume":"18","author":"Souza","year":"2020","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Andreassen, R., J\u00f6nsson, B., and Hadler-Olsen, E. (2022). Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Troms\u00f8 study. BMC Oral Health, 22.","DOI":"10.1186\/s12903-022-02140-2"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/cam4.3599","article-title":"Long-term quality of life & functional outcomes after treatment of oropharyngeal cancer","volume":"10","author":"Scott","year":"2021","journal-title":"Cancer Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1089\/lrb.2021.0041","article-title":"Validity Testing of the Head and Neck Lymphedema and Fibrosis Symptom Inventory","volume":"20","author":"Deng","year":"2022","journal-title":"Lymphat. Res. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Harrowfield, J., Isenring, E., Kiss, N., Laing, E., Lipson-Smith, R., and Britton, B. (2021). The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes. Nutrients, 13.","DOI":"10.3390\/nu13020514"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Ramalingam, K., Yadalam, P.K., Ramani, P., Krishna, M., Hafedh, S., Badnjevi\u0107, A., Cervino, G., and Minervini, G. (2024). Light gradient boosting-based prediction of quality of life among oral cancer-treated patients. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-04050-x"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"107068","DOI":"10.1016\/j.oraloncology.2024.107068","article-title":"Agreement between patient-reported and clinician-rated speech and swallowing outcomes\u2014Understanding the trend in post-operative oral cavity cancer patients","volume":"159","author":"Balaji","year":"2024","journal-title":"Oral Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"913S","DOI":"10.1177\/0145561320929941","article-title":"Voice Quality, Function, and Quality of Life for Laryngeal Cancer: A Prospective Longitudinal Study Up to 24 Months Following Radiotherapy","volume":"100","author":"Tuomi","year":"2021","journal-title":"Ear Nose Throat J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00405-020-05850-x","article-title":"Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: Analysis of cases from the Head and Neck 5000 study","volume":"277","author":"Rogers","year":"2020","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Zivkovic, A., Jotic, A., Dozic, I., Randjelovic, S., Cirkovic, I., Medic, B., Milovanovic, J., Trivi\u0107, A., Korugic, A., and Vukasinovi\u0107, I. (2024). Role of Oxidative Stress and Inflammation in Postoperative Complications and Quality of Life After Laryngeal Cancer Surgery. Cells, 13.","DOI":"10.3390\/cells13231951"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.radonc.2020.04.021","article-title":"Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer","volume":"148","author":"Grant","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Jia, L., Yan, C., Liu, R., He, P., Liu, A., Yang, F., Huangfu, H., and Zhang, S. (2025). Early application value of flexible laryngoscope swallowing function assessment in patients after partial laryngectomy. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-86799-x"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1002\/cncr.33849","article-title":"Determinants of patient-reported xerostomia among long-term oropharyngeal cancer survivors","volume":"127","author":"Aggarwal","year":"2021","journal-title":"Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00455-021-10320-5","article-title":"Swallowing Exercise During Head and Neck Cancer Treatment: Results of a Randomized Trial","volume":"37","author":"Wessel","year":"2022","journal-title":"Dysphagia"},{"key":"ref_44","first-page":"617","article-title":"Effect of three tongue needles acupoints Lianquan (CV23) and Hegu (LI4) combined with swallowing training on the quality of life of laryngeal cancer patients with dysphagia after surgery","volume":"42","author":"Zhu","year":"2022","journal-title":"J. Tradit. Chin. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/0284186X.2021.1995891","article-title":"Effect of voice rehabilitation following radiotherapy for laryngeal cancer\u2014A 3-year follow-up of a randomised controlled trial","volume":"61","author":"Karlsson","year":"2022","journal-title":"Acta Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104586","DOI":"10.1016\/j.oraloncology.2020.104586","article-title":"Effectiveness of a guided self-help exercise program tailored to patients treated with total laryngectomy: Results of a multi-center randomized controlled trial","volume":"103","author":"Jansen","year":"2020","journal-title":"Oral Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1007\/s00520-020-05362-8","article-title":"Cost-effectiveness analysis of voice rehabilitation for patients with laryngeal cancer: A randomized controlled study","volume":"28","author":"Johansson","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1177\/01455613211058108","article-title":"Survival and swallowing function outcome impact factors analysis of surgery-oriented comprehensive treatment for hypopharyngeal cancer in a series of 122 patients","volume":"101","author":"Li","year":"2022","journal-title":"Ear Nose Throat J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/hed.27986","article-title":"Impact of Transoral Robotic Surgery Versus Radiation on Swallowing Function in Oropharyngeal Cancer Patients: A Sub-Study From a Randomized Trial","volume":"47","author":"Theurer","year":"2025","journal-title":"Head Neck"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40463-021-00499-w","article-title":"Quality of life after Supracricoid Partial Laryngectomy","volume":"50","author":"Nakai","year":"2021","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/jso.28034","article-title":"Efficacy of Oral Rehabilitation Techniques in Patients With Oral Cancer: A Systematic Review and Meta-Analysis","volume":"131","author":"Saini","year":"2024","journal-title":"J. Surg. Oncol."},{"key":"ref_53","first-page":"CD006386","article-title":"Interventions for the treatment of oral cavity and oropharyngeal cancer: Chemotherapy","volume":"12","author":"Parmar","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/lary.21845","article-title":"Transoral robotic resection and reconstruction for head and neck cancer","volume":"121","author":"Genden","year":"2011","journal-title":"Laryngoscope"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00405-014-2985-7","article-title":"Functional outcomes after TORS for oropharyngeal cancer: A systematic review","volume":"272","author":"Hutcheson","year":"2015","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/jamaoto.2019.2725","article-title":"Dysphagia After Primary Transoral Robotic Surgery With Neck Dissection vs Nonsurgical Therapy in Patients With Lowto Intermediate-Risk Oropharyngeal Cancer","volume":"145","author":"Hutcheson","year":"2019","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1007\/s00405-015-3540-x","article-title":"Severe prolonged dysphagia following transoral resection of bilateral synchronous tonsillar carcinoma","volume":"272","author":"Patel","year":"2015","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_58","first-page":"1","article-title":"Modeling Dose Response for Late Dysphagia in Patients With Head and Neck Cancer in the Modern Era of Definitive Chemoradiation","volume":"1","author":"Tsai","year":"2017","journal-title":"JCO Clin. Cancer Inf."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e70050","DOI":"10.1002\/lio2.70050","article-title":"Tracheoesophageal puncture and quality of life after total laryngectomy: A systematic review and meta-analysis","volume":"9","author":"Bourmand","year":"2024","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1017\/S0022215121002887","article-title":"Functional outcomes of early laryngeal cancer\u2014Endoscopic laser surgery versus external beam radiotherapy: A systematic review","volume":"136","author":"Boyle","year":"2022","journal-title":"J. Laryngol. Otol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"103827","DOI":"10.1016\/j.ijnurstu.2020.103827","article-title":"Swallowing exercises for head and neck cancer patients: A systematic review and meta-analysis of randomized control trials","volume":"114","author":"Banda","year":"2021","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1002\/hed.27495","article-title":"Health-related quality of life, functional outcomes, and complications after sentinel lymph node biopsy and elective neck dissection in early oral cancer: A systematic review","volume":"45","author":"McDonald","year":"2023","journal-title":"Head Neck"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/lary.29027","article-title":"Health-Related Quality of Life Following Total Laryngectomy: A Systematic Review","volume":"131","author":"Wulff","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zahavi, D., and Weiner, L. (2020). Monoclonal Antibodies in Cancer Therapy. Antibodies, 9.","DOI":"10.3390\/antib9030034"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/7\/379\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:02:09Z","timestamp":1760032929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/7\/379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["curroncol32070379"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32070379","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}