{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:21:52Z","timestamp":1783574512493,"version":"3.55.0"},"reference-count":35,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2023 Canadian Cancer Society\/Canadian Institutes of Health Research Breakthrough Team Grant","award":["707709"],"award-info":[{"award-number":["707709"]}]},{"name":"Christine and Herschel Victor\/Hope &amp; Cope Chair in Psychosocial Oncology","award":["707709"],"award-info":[{"award-number":["707709"]}]},{"name":"Cholangiocarcinoma Foundation","award":["707709"],"award-info":[{"award-number":["707709"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Person-centered navigation (PCN) in healthcare refers to a proactive collaboration among professionals, researchers, patients, and their families to guide individuals toward timely access to screening, treatment, follow-up, and psychosocial support. PCN\u2014which includes professional, peer, and virtual guidance, is particularly crucial for rare cancers, where affected individuals face uncertainty, limited support, financial strain, and difficulties accessing relevant information, testing, and other services. The Canadian Cholangiocarcinoma Collaborative (C3) prioritizes PCN implementation to address these challenges in the context of Biliary Tract Cancers (BTCs). C3 uses a virtual PCN model and staffs a \u201cC3 Research Navigator\u201d who provides clinical and research navigation such as personalized guidance and support, facilitating access to molecular testing, clinical trials, and case reviews through national multidisciplinary rounds. C3 also supports a national network of BTC experts, a patient research registry, and advocacy activities. C3\u2019s implementation strategies include co-design, timely delivery of support, and optimal outcomes across its many initiatives. Future priorities include expanding the C3 network, enhancing user engagement, and further integrating its innovative approach into routine care.<\/jats:p>","DOI":"10.3390\/curroncol32080436","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T16:41:54Z","timestamp":1754325714000},"page":"436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Implementing Person-Centered, Clinical, and Research Navigation in Rare Cancers: The Canadian Cholangiocarcinoma Collaborative (C3)"],"prefix":"10.3390","volume":"32","author":[{"given":"Samar","family":"Attieh","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"},{"name":"Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-6054","authenticated-orcid":false,"given":"Leonard","family":"Angka","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Lafontaine","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Patient Representative, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Carignan","sequence":"additional","affiliation":[{"name":"Patient Representative, Quebec City, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ilkow","sequence":"additional","affiliation":[{"name":"Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"},{"name":"Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Turcotte","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie, Service de Transplantation H\u00e9patique et de Chirurgie H\u00e9patopancr\u00e9atobiliaire, Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al, Montreal, QC H2X 0C1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Goodwin","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, The Ottawa Hospital, University of Ottawa, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Auer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"},{"name":"Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada"},{"name":"Patient Representative, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-2645","authenticated-orcid":false,"given":"Carmen G.","family":"Loiselle","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology and Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3A 2M7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref_1","unstructured":"Portfolio, C.J. (2025, July 29). Navigation: A Guide to Implementing Best Practices in Person-Centred Care. Canadian Partnership Against Cancer. 2012. Available online: https:\/\/www.partnershipagainstcancer.ca\/wp-content\/uploads\/2018\/12\/Implementing-Navigation-Guide-EN.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.3390\/curroncol29020099","article-title":"Peer support needs and preferences for digital peer navigation among adolescent and young adults with cancer: A Canadian cross-sectional survey","volume":"29","author":"Bender","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.3390\/curroncol29060343","article-title":"Web-based peer navigation for men with prostate cancer and their family caregivers: A pilot feasibility study","volume":"29","author":"Bender","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/cncr.23815","article-title":"Patient navigation: State of the art or is it science?","volume":"113","author":"Wells","year":"2008","journal-title":"Cancer"},{"key":"ref_5","first-page":"1369","article-title":"Effects of patient navigation on satisfaction with cancer care: A systematic review and meta-analysis","volume":"26","author":"Wells","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5737\/236880763014853","article-title":"The nurse pivot-navigator associated with more positive cancer care experiences and higher patient satisfaction","volume":"30","author":"Loiselle","year":"2020","journal-title":"Can. Oncol. Nurs. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.pec.2016.10.014","article-title":"The effectiveness of patient navigation to improve healthcare utilization outcomes: A meta-analysis of randomized controlled trials","volume":"100","author":"Colella","year":"2017","journal-title":"Patient Educ. Couns."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1200\/JCO.2016.67.5454","article-title":"Patient navigation in breast cancer treatment and survivorship: A systematic review","volume":"34","author":"Baik","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/cncr.32147","article-title":"The efficacy and cost-effectiveness of patient navigation programs across the cancer continuum: A systematic review","volume":"125","author":"Bernardo","year":"2019","journal-title":"Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Dixit, N., Rugo, H., and Burke, N.J. (2021). Navigating a path to equity in cancer care: The role of patient navigation. American Society of Clinical Oncology Educational Book, American Society of Clinical Oncology.","DOI":"10.1200\/EDBK_100026"},{"key":"ref_11","first-page":"565","article-title":"Patient navigation across the cancer care continuum: An overview of systematic reviews and emerging literature","volume":"73","author":"Chan","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jhep.2017.03.011","article-title":"Global trends and predictions in hepatocellular carcinoma mortality","volume":"67","author":"Bertuccio","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41575-020-0310-z","article-title":"Cholangiocarcinoma 2020: The next horizon in mechanisms and management","volume":"17","author":"Banales","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"EVIDoa2200015","DOI":"10.1056\/EVIDoa2200015","article-title":"Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer","volume":"1","author":"Oh","year":"2022","journal-title":"NEJM Evid."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1080\/09638288.2022.2099589","article-title":"Rare cancer and return to work: Experiences and needs of patients and (health care) professionals","volume":"45","author":"Brom","year":"2023","journal-title":"Disabil. Rehabil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"101506","DOI":"10.1016\/j.copsyc.2022.101506","article-title":"Hope and cancer","volume":"49","author":"Feldman","year":"2023","journal-title":"Curr. Opin. Psychol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13012-019-0876-4","article-title":"Specifying and comparing implementation strategies across seven large implementation interventions: A practical application of theory","volume":"14","author":"Perry","year":"2019","journal-title":"Implement. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13012-015-0209-1","article-title":"A refined compilation of implementation strategies: Results from the Expert Recommendations for Implementing Change (ERIC) project","volume":"10","author":"Powell","year":"2015","journal-title":"Implement. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Beaudry, F.E., Li, Z., Borgida, A., Zorigtbaatar, A., Wang, X., Hildebrand, M., Hamza, O., Jang, G.H., Bucur, R., and Dodd, A. (2025). Molecular Tumor Board-Guided Targeted Treatments for Biliary Tract Cancers in a Publicly Funded Healthcare System. Curr. Oncol., 32.","DOI":"10.3390\/curroncol32020080"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41571-023-00824-4","article-title":"Molecular tumour boards\u2014Current and future considerations for precision oncology","volume":"20","author":"Tsimberidou","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1158\/1078-0432.CCR-21-2384","article-title":"ESMO scale for clinical actionability of molecular targets driving targeted treatment in patients with cholangiocarcinoma","volume":"28","author":"Verdaguer","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1002\/cncr.33618","article-title":"Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities","volume":"127","author":"Stacchiotti","year":"2021","journal-title":"Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Valery, M., Vasseur, D., Fachinetti, F., Boil\u00e8ve, A., Smolenschi, C., Tarabay, A., Antoun, L., Perret, A., Fuerea, A., and Pudlarz, T. (2023). Targetable molecular alterations in the treatment of biliary tract cancers: An overview of the available treatments. Cancers, 15.","DOI":"10.3390\/cancers15184446"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"217540","DOI":"10.1016\/j.canlet.2025.217540","article-title":"Current status and prospects of targeted therapy for cholangiocarcinoma based on molecular characteristics","volume":"614","author":"Cui","year":"2025","journal-title":"Cancer Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ejon.2008.11.003","article-title":"The loneliness of cancer","volume":"12","author":"Wells","year":"2008","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_26","first-page":"26330040231164425","article-title":"Emerging roles and opportunities for rare disease patient advocacy groups","volume":"4","author":"Patterson","year":"2023","journal-title":"Ther. Adv. Rare Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13023-016-0382-6","article-title":"The involvement of patient organisations in rare disease research: A mixed methods study in Australia","volume":"11","author":"Pinto","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13023-019-1093-6","article-title":"The role of patient organizations in the rare disease ecosystem in India: An interview based study","volume":"14","author":"Choudhury","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/S1470-2045(15)00388-5","article-title":"The value of research collaborations and consortia in rare cancers","volume":"17","author":"Blay","year":"2016","journal-title":"Lancet Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.beth.2017.11.012","article-title":"A method for tracking implementation strategies: An exemplar implementing measurement-based care in community behavioral health clinics","volume":"49","author":"Boyd","year":"2018","journal-title":"Behav. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/j.1556-6678.2009.tb00556.x","article-title":"Diffusion of innovation theory: A bridge for the research-practice gap in counseling","volume":"87","author":"Murray","year":"2009","journal-title":"J. Couns. Dev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1151\/spp073220","article-title":"Assessing organizational functioning as a step toward innovation","volume":"3","author":"Simpson","year":"2007","journal-title":"Sci. Pract. Perspect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1108\/09576060210436669","article-title":"Implementing strategies successfully","volume":"13","author":"Aaltonen","year":"2002","journal-title":"Integr. Manuf. Syst."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5737\/23688076334385","article-title":"An integrative review on the oncology nurse navigator role in the Canadian context","volume":"33","author":"Katerenchuk","year":"2023","journal-title":"Can. Oncol. Nurs. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"26323524241288873","DOI":"10.1177\/26323524241288873","article-title":"Adapting, implementing and evaluating a navigation intervention for older people with cancer and their family caregivers in six countries in Europe: The Horizon Europe-funded EU NAVIGATE project","volume":"18","author":"Miranda","year":"2024","journal-title":"Palliat. Care Soc. Pract."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/8\/436\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:20:56Z","timestamp":1760034056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/8\/436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["curroncol32080436"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32080436","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}