{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:22:33Z","timestamp":1764829353149,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NL Support\/Quality of Care Graduate Student Fellowship","award":["707146"],"award-info":[{"award-number":["707146"]}]},{"name":"Canadian Cancer Society Emerging Scholar","award":["707146"],"award-info":[{"award-number":["707146"]}]},{"name":"YACC with partial funding from NL Support Patient-Oriented Research Development Award","award":["707146"],"award-info":[{"award-number":["707146"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Adolescents and young adults (AYAs) diagnosed with cancer between the ages of 15 and 39 years face unique challenges that impact their long-term quality of life (QoL). Physical functioning, relationship status, social support, anxiety, and depression have been associated with QoL in AYAs with cancer. This study explored factors associated with increased QoL in a sample of 392 AYAs with cancer in Canada who participated in the initial Young Adult Cancer Canada RECOVER survey. The EORTC QLQ-C30 was used to measure QoL. Adjusting for relevant demographic, cancer, and clinical variables, the only factors significantly associated with QoL in multivariable analysis were symptoms of depression [Mild (\u03b2 = \u22120.420, p &lt; 0.001); Moderate (\u03b2 = \u22120.937, p &lt; 0.001); Moderately Severe (\u03b2 = \u22121.188, p &lt; 0.001); Severe (\u03b2 = \u22122.182, p &lt; 0.001)] and generalized anxiety [Mild (\u03b2 = \u22120.244, p = 0.012); Moderate (\u03b2 = \u22120.420, p = 0.002); Moderately severe (\u03b2 = \u22120.400, p = 0.012); Severe (\u03b2 = \u22120.697, p = 0.010)], as well as having completed treatment (\u03b2 = \u22120.347, p &lt; 0.001). Age, gender, time since diagnosis, having children, education, income, fear of recurrence, and social support were not significantly associated with QoL. These results support the need for age-appropriate resources to help AYAs manage the long-term psychological impacts of cancer.<\/jats:p>","DOI":"10.3390\/curroncol32090475","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:31:26Z","timestamp":1755865886000},"page":"475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated with Quality of Life (QoL) in Adolescents and Young Adults with Cancer"],"prefix":"10.3390","volume":"32","author":[{"given":"Reanna","family":"George","sequence":"first","affiliation":[{"name":"Department of Psychology, Faculty of Science, Memorial University, St. John\u2019s, NL A1B 3X9, Canada"},{"name":"Beatrice Hunter Cancer Research Institute, Halifax, NS B3H 0A2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoff","family":"Eaton","sequence":"additional","affiliation":[{"name":"Young Adult Cancer Canada (YACC), St. John\u2019s, NL A1A5B5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-4437","authenticated-orcid":false,"given":"Pam","family":"Crotty","sequence":"additional","affiliation":[{"name":"Young Adult Cancer Canada (YACC), St. John\u2019s, NL A1A5B5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Heykoop","sequence":"additional","affiliation":[{"name":"Faculty of Leadership Studies, Royal Roads University, Victoria, BC V9B 5Y2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6071-0042","authenticated-orcid":false,"given":"Sapna","family":"Oberoi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3A 1S1, Canada"},{"name":"Department of Pediatric Hematology-Oncology, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-0712","authenticated-orcid":false,"given":"Joshua A.","family":"Rash","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Science, Memorial University, St. John\u2019s, NL A1B 3X9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-318X","authenticated-orcid":false,"given":"Sheila N.","family":"Garland","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Science, Memorial University, St. John\u2019s, NL A1B 3X9, Canada"},{"name":"Beatrice Hunter Cancer Research Institute, Halifax, NS B3H 0A2, Canada"},{"name":"Discipline of Oncology, Faculty of Medicine, Memorial University, St. John\u2019s, NL A1B 3X5, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1002\/cncr.27512","article-title":"Positive and negative psychosocial impact of being diagnosed with cancer as an adolescent or young adult","volume":"118","author":"Bellizzi","year":"2012","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s11764-013-0302-x","article-title":"Health-related quality of life in young men with testicular cancer: Validation of the Cancer Assessment for Young Adults (CAYA)","volume":"7","author":"Hoyt","year":"2013","journal-title":"J. Cancer Surviv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10880-018-9566-7","article-title":"Impact of Cancer on Romantic Relationships Among Young Adults: A Systematic Review","volume":"26","author":"Rabin","year":"2019","journal-title":"J. Clin. Psychol. Med. Settings"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.seminoncol.2009.03.003","article-title":"Cancer in Young Adults 20 to 39 Years of Age: Overview","volume":"36","author":"Bleyer","year":"2009","journal-title":"Semin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/cncr.29869","article-title":"Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults","volume":"122","author":"Keegan","year":"2016","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/pon.3218","article-title":"Social support and quality of life among lung cancer patients: A systematic review","volume":"22","author":"Luszczynska","year":"2013","journal-title":"Psycho-Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/cncr.33372","article-title":"Quality of life among survivors of adolescent and young adult cancer in Canada: A Young Adults With Cancer in Their Prime (YACPRIME) study","volume":"127","author":"Schulte","year":"2021","journal-title":"Cancer"},{"key":"ref_8","first-page":"298","article-title":"Functional quality of life among newly diagnosed young adult colorectal cancer survivors compared to older adults: Results from the ColoCare Study","volume":"35","author":"Oswald","year":"2024","journal-title":"Support. Care Cancer Off. J. Multinatl. Assoc. Support. Care Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1200\/JCO.22.02195","article-title":"Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery: Real-World Data From the International GOSAFE Study","volume":"41","author":"Montroni","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103866","DOI":"10.1016\/j.breast.2024.103866","article-title":"Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort","volume":"79","author":"Rotolo","year":"2025","journal-title":"Breast"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s11136-005-4324-3","article-title":"Assessment of Anxiety and Depression in Advanced Cancer Patients and their Relationship with Quality of Life","volume":"14","author":"Mystakidou","year":"2005","journal-title":"Qual. Life Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S1478951507070198","article-title":"Unmet needs among adolescent cancer patients: A pilot study","volume":"5","author":"Palmer","year":"2007","journal-title":"Palliat Support Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"15347354221081271","DOI":"10.1177\/15347354221081271","article-title":"Effects of Cognitive Training and Social Support on Cancer-Related Fatigue and Quality of Life in Colorectal Cancer Survivors: A Systematic Review and Meta-Analysis","volume":"21","author":"Dun","year":"2022","journal-title":"Integr. Cancer Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.4314\/ejhs.v32i4.6","article-title":"Social support and meaning of life in women with breast cancer","volume":"32","author":"Jadidi","year":"2022","journal-title":"Ethiop. J. Health Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cartmell, K.B., Sterba, K.R., Pickett, K., Zapka, J., Alberg, A.J., Sood, A.J., and Esnaola, N.F. (2018). Availability of patient-centered cancer support services: A statewide survey of cancer centers. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0194649"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jclinepi.2015.08.007","article-title":"Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust","volume":"69","author":"Giesinger","year":"2016","journal-title":"J. Clin. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e722","DOI":"10.1634\/theoncologist.2019-0348","article-title":"The EORTC QLQ-C30 Summary Score as Prognostic Factor for Survival of Patients with Cancer in the \u201cReal-World\u201d: Results from the Population-Based PROFILES Registry","volume":"25","author":"Husson","year":"2020","journal-title":"Oncologist"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s43163-024-00642-0","article-title":"Cut-off points to classify numeric values of quality of life into normal, mild, moderate, and severe categories: An update for EORTC-QLQ-H&N35","volume":"40","author":"Saini","year":"2024","journal-title":"Egypt. J. Otolaryngol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1001\/jama.282.18.1737","article-title":"Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire","volume":"282","author":"Spitzer","year":"1999","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/jayao.2016.0018","article-title":"Against a Singular Message of Distinctness: Challenging Dominant Representations of Adolescents and Young Adults in Oncology","volume":"6","author":"Hammond","year":"2016","journal-title":"J. Adolesc. Young Adult Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11764-019-00802-9","article-title":"Prevalence and factors associated with fear of recurrence in a mixed sample of young adults with cancer","volume":"13","author":"Lane","year":"2019","journal-title":"J. Cancer Surviv."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Chen, Z., Ni, P., Wu, B., Ko, E., Liao, J., Lin, H., and Ma, P. (2025). Fear of cancer recurrence among adolescent and young adult cancer survivors: A mixed-methods systematic review. J. Cancer Surviv.","DOI":"10.1007\/s11764-025-01812-6"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1007\/s11136-022-03139-6","article-title":"Identifying health-related quality of life cut-off scores that indicate the need for supportive care in young adults with cancer","volume":"31","author":"Lidington","year":"2022","journal-title":"Qual. Life Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11764-021-00998-9","article-title":"The financial impact of cancer on Canadian young adults","volume":"17","author":"Mahon","year":"2023","journal-title":"J. Cancer Surviv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2300418","DOI":"10.1200\/GO.23.00418","article-title":"International Survey of Psychosocial Care for Cancer Survivors in Low-\/Middle- and High-Income Countries: Current Practices, Barriers, and Facilitators to Care","volume":"10","author":"Signorelli","year":"2024","journal-title":"JCO Glob. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1200\/OP.21.00663","article-title":"Financial Hardship in Adolescent and Young Adult Oncology: The Need for Multidimensional and Multilevel Approaches","volume":"18","author":"Salsman","year":"2022","journal-title":"JCO Oncol. Pract."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.6004\/jnccn.2023.7067","article-title":"What Constitutes Quality of Life? Perspectives of Adolescents and Young Adults With Advanced Cancer","volume":"21","author":"Hinkle","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e70328","DOI":"10.1002\/cam4.70328","article-title":"Predictors and Interdependence of Quality of Life in a Random Sample of Long-Term Young Breast Cancer Survivors and Their Biological Relatives","volume":"13","author":"Ellis","year":"2024","journal-title":"Cancer Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1634\/theoncologist.2016-0245","article-title":"Accessibility, Availability, and Potential Benefits of Psycho-Oncology Services: The Perspective of Community-Based Physicians Providing Cancer Survivorship Care","volume":"22","author":"Hartmann","year":"2017","journal-title":"Oncologist"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/gyno.2001.6345","article-title":"A longitudinal study on quality of life after gynecologic cancer treatment","volume":"83","author":"Chan","year":"2001","journal-title":"Gynecol. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/9\/475\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:33:57Z","timestamp":1760034837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/32\/9\/475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":31,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["curroncol32090475"],"URL":"https:\/\/doi.org\/10.3390\/curroncol32090475","relation":{},"ISSN":["1718-7729"],"issn-type":[{"type":"electronic","value":"1718-7729"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}