{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:37:12Z","timestamp":1790829432010,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>This nationwide cohort study investigated whether a single episode of acute exposure to high-dose acetylcholinesterase (AChE) inhibitor insecticide is associated with an increased risk of pancreatic cancer. Data from the Korean National Health Insurance Service were analyzed. The case group (n = 938) included adults exposed to organophosphate or carbamate insecticide and the control group (n = 3752) was matched by age, sex, and socioeconomic status. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals. Kaplan\u2013Meier curves with log-rank tests evaluated differences in pancreatic cancer incidence. Over 33,219.8 person-years of follow-up, pancreatic cancer developed in 9 patients in the case group and 19 patients in the control group. The cumulative incidence of pancreatic cancer was significantly higher in the case group (log-rank p &lt; 0.01). Acute high-dose exposure to AChE inhibitor insecticide was associated with an increased risk of pancreatic cancer (adjusted HR: 2.57). The risk was particularly elevated among women (HR: 5.85) and individuals with diabetes (HR: 2.75). Acute high-dose exposure to AChE inhibitor insecticide may increase the risk of pancreatic cancer. Women and those with diabetes may represent high-risk subgroups. These findings highlight the need for targeted cancer surveillance and further confirmatory studies.<\/jats:p>","DOI":"10.3390\/curroncol32100528","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:32:53Z","timestamp":1758637973000},"page":"528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Risk of Pancreatic Cancer After Acute Acetylcholinesterase Inhibitor Insecticide Exposure: A Nationwide Cohort Study"],"prefix":"10.3390","volume":"32","author":[{"given":"JeongMi","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Hospital, Gwangju 61487, Republic of Korea"},{"name":"Department of Emergency Medicine, Chonnam National University Medical School, Hak Dong 8, Gwangju 61469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EuJene","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Hospital, Gwangju 61487, Republic of Korea"},{"name":"Department of Emergency Medicine, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ByeongJo","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Medical School, Hak Dong 8, Gwangju 61469, Republic of Korea"},{"name":"Department of Emergency Medicine, Chonnam National University Hwasun Hospital, Hwasun 58128, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongKi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Hospital, Gwangju 61487, Republic of Korea"},{"name":"Department of Emergency Medicine, Chonnam National University Medical School, Hak Dong 8, Gwangju 61469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YeonJi","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University Hospital, Gwangju 61487, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.3748\/wjg.v27.i27.4298","article-title":"Pancreatic cancer: A review of epidemiology, trend, and risk factors","volume":"27","author":"Hu","year":"2021","journal-title":"World J. 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