{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:51:06Z","timestamp":1785153066572,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Febrile neutropenia (FN) is a serious chemotherapy-related complication in patients with solid tumors. Identifying simple and accessible biomarkers that can predict prolonged hospitalization may support early risk stratification and clinical decision-making. Methods: This retrospective study included 169 adults hospitalized with FN between January 2023 and January 2025. Immunonutritional indices, including the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score, the Prognostic Nutritional Index (PNI), and the C-reactive protein\/albumin ratio (CAR), as well as the Clinical Index of Stable Febrile Neutropenia (CISNE) score were calculated. HALP and PNI were categorized using ROC-derived cut-offs based on the Youden Index. Prolonged hospital stay was defined as a binary variable based on the cohort median (&gt;9 days). Spearman correlation, univariate and multivariate logistic regression were performed to identify predictors of prolonged hospitalization. Results: HALP showed a significant negative correlation with hospitalization duration (r = \u22120.469; p &lt; 0.001), as did serum albumin (r = \u22120.184; p = 0.017) and PNI (r = \u22120.273; p &lt; 0.001). CAR (p = 0.617) and neutrophil count (p = 0.955) demonstrated no correlation. In univariate logistic regression, low HALP (p &lt; 0.001), low PNI (p = 0.001), intermediate CISNE (p = 0.002), high CISNE (p &lt; 0.001), microbiological culture positivity (p &lt; 0.001), and sex (p = 0.015) were significantly associated with prolonged hospitalization. Age, comorbidity status, metastatic stage, and CAR were not significant. In the multivariate model, low HALP (p &lt; 0.001), intermediate CISNE (p = 0.007), high CISNE (p &lt; 0.001), and culture positivity (p &lt; 0.001) remained independent predictors. PNI (p = 0.400) and sex (p = 0.176) did not retain significance. Conclusions: A Low HALP score, higher CISNE risk categories, and microbiological culture positivity independently predicted prolonged hospitalization in FN. HALP, as a simple and inexpensive immunonutritional marker, may enhance early FN risk assessment when used alongside validated clinical tools such as CISNE or MASCC.<\/jats:p>","DOI":"10.3390\/curroncol33010014","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T23:54:36Z","timestamp":1766966076000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Low HALP Score Predicts Prolonged Hospitalization in Solid Tumor Patients with Febrile Neutropenia"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-1606","authenticated-orcid":false,"given":"Salih","family":"Karatl\u0131","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Etlik City Hospital, 06170 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-7870","authenticated-orcid":false,"given":"Do\u011fan","family":"Yaz\u0131l\u0131ta\u015f","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Etlik City Hospital, 06170 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/01.JAA.0000000000000054","article-title":"Evaluation and management of febrile neutropenia in patients with cancer","volume":"37","author":"Cossey","year":"2024","journal-title":"JAAPA"},{"key":"ref_2","first-page":"73","article-title":"Association of an emergency department febrile neutropenia intervention protocol with time to initial antibiotic treatment","volume":"79","author":"Seltzer","year":"2022","journal-title":"Ann. 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