{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:03:51Z","timestamp":1767899031949,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022SF52"],"award-info":[{"award-number":["2022SF52"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>The use of deep learning radiomics to predict whether advanced prostate cancer (PCa) will progress within two years after treatment has been validated, yet there remains a lack of research on estimating time to progression. Patients were enrolled from October 2017 to March 2024. One hundred and eighty-two patients with advanced PCa diagnosed through ultrasound-guided systematic prostate biopsy were enrolled. A deep learning-based radiomics model for predicting progression was firstly developed using pretreatment MR apparent diffusion coefficient (ADC) maps, and the performance of manual (ROIref) versus AI-derived (ROIai) tumor segmentations was compared. Then, survival analysis was performed to compare ROIref-based and ROIai-based radiomics-predicted probabilities in the risk stratification. The area under the receiver operating characteristics curve (AUC) was used to estimate the model efficacy. The model achieved high AUC values for progression prediction in test sets (ROIref: 0.840, ROIai: 0.852). No significant difference was observed between ROIai-based and ROIref-based approaches (\u0394AUC = 0.012, p = 0.870) in the test set. Both ROIref-predicted and ROIai-predicted probabilities independently predicted progression in multivariate Cox proportional hazard regression models (p &lt; 0.001) and stratified patients into distinct survival groups (log-rank p &lt; 0.001). Decision curve analysis confirmed equivalent clinical utility across thresholds (0.1\u20130.6), with net benefit exceeding the \u201ctreat all\u201d and \u201ctreat none\u201d strategies. In conclusion, deep learning-based radiomics models could effectively predict advanced PCa progression, with AI-derived tumor annotations performing equally to manual expert ones.<\/jats:p>","DOI":"10.3390\/curroncol33010035","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T14:32:38Z","timestamp":1767882758000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An AI-Based Radiomics Model Using MRI ADC Maps for Accurate Prediction of Advanced Prostate Cancer Progression"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9184-3967","authenticated-orcid":false,"given":"Kexin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5908-9394","authenticated-orcid":false,"given":"Pengsheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Smart Tree Medical Technology Co., Ltd., Beijing 102200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuke","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-6623","authenticated-orcid":false,"given":"Huihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Peking University First Hospital, Beijing 100034, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"811044","DOI":"10.3389\/fpubh.2022.811044","article-title":"Prostate Cancer Incidence and Mortality: Global Status and Temporal Trends in 89 Countries from 2000 to 2019","volume":"10","author":"Wang","year":"2022","journal-title":"Front. 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