{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:21:36Z","timestamp":1793042496853,"version":"4.5.0"},"reference-count":167,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>High-risk benign breast lesions are histological abnormalities that present in breast tissue, typically identified by screening or diagnostic imaging. The presence of invasive or in situ breast cancer can be confirmed or ruled out within these lesions, and the risk of developing breast cancer can be reduced by their appropriate management. These potential high-risk lesions reviewed include atypical ductal hyperplasia, mucocele-like lesions, papillary lesions with or without atypia, radial scar\/complex sclerosing lesion with or without atypia, atypical lobular hyperplasia, classical lobular carcinoma in situ, pleomorphic\/florid lobular carcinoma in situ, flat epithelial atypia, columnar cell change, fibroepithelial lesions with stromal cellularity, spindle cell lesions\/mesenchymal lesions, and microglandular adenosis. The lack of a clear consensus on the management of many of these lesions led the Ontario Health (Cancer Care Ontario) (OH-CCO) Breast Cancer Pathway Map Working Group and Breast Cancer Advisory Committee to identify the need for a recommendation document. A multidisciplinary working group was formed, with members representing surgical oncology, radiology, pathology, medical oncology, and genetic counselling. The working group developed a list of high-risk benign lesions to be included in this recommendation report. An updated literature review was completed, and these publications were reviewed by the working group, and recommendations were drafted. When evidence was lacking, the expert opinion was included. These draft recommendations were subjected to an extensive review by experts both within Cancer Care Ontario and across Canada. The recommendations included in this report are relevant to clinicians, primary care physicians, oncologists, radiologists, and pathologists who treat breast cancer and manage breast conditions.<\/jats:p>","DOI":"10.3390\/curroncol33020067","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T16:13:48Z","timestamp":1769444028000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Risk Benign Breast Lesions: An Ontario Health (Cancer Care Ontario) Recommendations Report"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8037-9556","authenticated-orcid":false,"given":"Andrea","family":"Eisen","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Hamilton Health Sciences, University of Toronto, Toronto, ON M5S 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Bane","sequence":"additional","affiliation":[{"name":"Pathology, University Health Network, University of Toronto, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrina","family":"Causer","sequence":"additional","affiliation":[{"name":"Radiology, North York General Hospital, University of Toronto, Toronto, ON M2K 1E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Surgical Oncology, The Ottaway Hospital, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9314-657X","authenticated-orcid":false,"given":"Samantha","family":"Fienberg","sequence":"additional","affiliation":[{"name":"Radiology, Lakeridge Health, University of Toronto, Toronto, ON M5S 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-2091","authenticated-orcid":false,"given":"Anat","family":"Kornecki","sequence":"additional","affiliation":[{"name":"Radiology, St. Joseph Health Centre, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameya","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Radiology, Hamilton Health Sciences Centre, McMaster University, Hamilton, ON L8S 4L8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Look","family":"Hong","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Genetic Counselling, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Muradali","sequence":"additional","affiliation":[{"name":"Radiology, St. Michael\u2019s Hospital, University of Toronto, Toronto, ON M5G 2C4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Nofech-Mozes","sequence":"additional","affiliation":[{"name":"Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-0316","authenticated-orcid":false,"given":"Amanda","family":"Roberts","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Radiology, Peterborough Regional Health Centre, Peterborough, ON K9J 7C6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Courtney","sequence":"additional","affiliation":[{"name":"Ontario Health (Cancer Care Ontario), 500-525 University Avenue, Toronto, ON M5G 2L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Grove","sequence":"additional","affiliation":[{"name":"Ontario Health (Cancer Care Ontario), 500-525 University Avenue, Toronto, ON M5G 2L3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-2199","authenticated-orcid":false,"given":"Muriel","family":"Brackstone","sequence":"additional","affiliation":[{"name":"Ontario Health (Cancer Care Ontario), 500-525 University Avenue, Toronto, ON M5G 2L3, Canada"},{"name":"Surgical Oncology, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.suc.2012.12.005","article-title":"Surgical management of high-risk breast lesions","volume":"93","author":"Degnim","year":"2013","journal-title":"Surg. 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