{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:03:02Z","timestamp":1790283782281,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["IF230264"],"award-info":[{"award-number":["IF230264"]}],"id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["DBT-RA\/2023-24\/Call-1\/RA\/27"],"award-info":[{"award-number":["DBT-RA\/2023-24\/Call-1\/RA\/27"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Glioblastoma multiforme (GBM) is one of the most aggressive and treatment-resistant forms of brain cancer, posing challenges to modern oncology. Current treatments, including surgery, radiation, and chemotherapy (e.g., Temozolomide or TMZ), often fail due to the inevitable development of drug resistance. TMZ resistance remains a major therapeutic challenge for the reasons that it is the first-line treatment. Recent studies indicate a rising GBM tumour burden and a trend towards earlier age of onset. It highlights the urgent need for evidence-based policymaking and intensified research to address this most difficult-to-treat malignancy in clinical settings. Ferroptosis, a newly recognized type of controlled cell death induced by iron-dependent lipid peroxidation, has emerged as a potential approach to overcome apoptosis resistance and restore drug sensitivity in GBM. This mechanism is modulated by key molecules that can be specifically targeted to either enhance oxidative stress or inhibit antioxidant defences, ultimately leading to tumour cell death. This review conducts a meta-analysis of preclinical evidence to better understand the potential of activating ferroptosis as a key target for developing nanoparticles to resensitize TMZ-resistant GBM cells. Current evidence indicates that combining ferroptosis induction with strategically engineered nanocarrier systems can serve as a novel and effective therapeutic approach to overcome TMZ resistance and advance precision-based GBM treatment.<\/jats:p>","DOI":"10.3390\/curroncol33040194","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:41:53Z","timestamp":1774878113000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ferroptosis-Based Nanotherapeutic Strategies to Overcome Temozolomide Resistance in Glioblastoma: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1373-5683","authenticated-orcid":false,"given":"Yashaswi","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-9405","authenticated-orcid":false,"given":"Arpana","family":"Parihar","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-8550","authenticated-orcid":false,"given":"Neha","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagat","family":"Kanwar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7775-3428","authenticated-orcid":false,"given":"Murali","family":"Munisamy","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9910-3058","authenticated-orcid":false,"given":"Megha","family":"Katare-Pandey","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadev","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Udupi 567104, KA, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adesh","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences, Saket Nagar, Bhopal 462020, MP, 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(2025). Glioblastoma: Clinical Presentation, Multidisciplinary Management, and Long-Term Outcomes. Cancers, 17.","DOI":"10.3390\/cancers17010146"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1007\/s12011-023-03930-7","article-title":"Boric acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells","volume":"202","author":"Hacioglu","year":"2024","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1158\/1055-9965.EPI-14-0275","article-title":"Epidemiologic and molecular prognostic review of glioblastoma","volume":"23","author":"Thakkar","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1188\/16.CJON.S1.2-8","article-title":"Glioblastoma: Overview of Disease and Treatment","volume":"20","author":"Davis","year":"2016","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1200\/JCO.2017.73.0119","article-title":"Adult Glioblastoma","volume":"35","author":"Alexander","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/ncpneuro0289","article-title":"Epidemiology and molecular pathology of glioma","volume":"2","author":"Schwartzbaum","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13046-022-02349-7","article-title":"Emerging therapies for glioblastoma: Current state and future directions","volume":"41","author":"Rong","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1021\/acs.jmedchem.1c01946","article-title":"Glioblastoma: Current Status, Emerging Targets, and Recent Advances","volume":"65","author":"Thakur","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12013-022-01124-x","article-title":"Ferroptosis-related NFE2L2 and NOX4 Genes are Potential Risk Prognostic Biomarkers and Correlated with Immunogenic Features in Glioma","volume":"81","author":"Lin","year":"2023","journal-title":"Cell Biochem. Biophys."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sui, X., Zhang, R., Liu, S., Duan, T., Zhai, L., Zhang, M., Han, X., Xiang, Y., Huang, X., and Lin, H. (2018). RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01371"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.18632\/oncoscience.160","article-title":"Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells","volume":"2","author":"Eling","year":"2015","journal-title":"Oncoscience"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Mitre, A.O., Florian, A.I., Buruiana, A., Boer, A., Moldovan, I., Soritau, O., Florian, S.I., and Susman, S. (2022). Ferroptosis Involvement in Glioblastoma Treatment. Medicina, 58.","DOI":"10.3390\/medicina58020319"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/374814a0","article-title":"Programmed cell death and Bcl-2 protection in very low oxygen","volume":"374","author":"Jacobson","year":"1995","journal-title":"Nature"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhuo, S., He, G., Chen, T., Li, X., Liang, Y., Wu, W., Weng, L., Feng, J., Gao, Z., and Yang, K. (2022). Emerging role of ferroptosis in glioblastoma: Therapeutic opportunities and challenges. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.974156"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"12583","DOI":"10.1021\/acsomega.0c01592","article-title":"Nanocarriers as Potential Drug Delivery Candidates for Overcoming the Blood-Brain Barrier: Challenges and Possibilities","volume":"5","author":"Ahlawat","year":"2020","journal-title":"ACS Omega"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Carvalho, S.M., Mansur, A.A.P., da Silveira, I.B., Pires, T.F.S., Victoria, H.F.V., Krambrock, K., Leite, M.F., and Mansur, H.S. (2023). Nanozymes with Peroxidase-like Activity for Ferroptosis-Driven Biocatalytic Nanotherapeutics of Glioblastoma Cancer: 2D and 3D Spheroids Models. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061702"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.drudis.2021.04.008","article-title":"Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors","volume":"26","author":"Reddy","year":"2021","journal-title":"Drug Discov. Today"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hooijmans, C.R., Rovers, M.M., de Vries, R.B., Leenaars, M., Ritskes-Hoitinga, M., and Langendam, M.W. (2014). SYRCLE\u2019s risk of bias tool for animal studies. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-43"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/07357907.2016.1233424","article-title":"Deferiprone Enhances Temozolomide Cytotoxicity in Glioma Cells","volume":"34","author":"Alexiou","year":"2016","journal-title":"Cancer Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1593\/tlo.09274","article-title":"Transferrin receptor 2 is frequently and highly expressed in glioblastomas","volume":"3","author":"Calzolari","year":"2010","journal-title":"Transl. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chen, M., Kim, B., Robertson, N., Mondal, S.K., Medarova, Z., and Moore, A. (2023). Co-administration of temozolomide (TMZ) and the experimental therapeutic targeting miR-10b, profoundly affects the tumorigenic phenotype of human glioblastoma cells. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1179343"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101804","DOI":"10.1016\/j.redox.2020.101804","article-title":"Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy","volume":"38","author":"Cushing","year":"2021","journal-title":"Redox Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neurol.2019.09.007","article-title":"Major response to temozolomide as first-line treatment for newly-diagnosed DDR2-mutated glioblastoma: A case report","volume":"176","author":"Marguet","year":"2020","journal-title":"Rev. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/fcp.12539","article-title":"Deleterious impact of a generic temozolomide formulation compared with brand-name product on the kinetic of platelet concentration and survival in newly diagnosed glioblastoma","volume":"34","author":"Fontanilles","year":"2020","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s40478-024-01861-5","article-title":"Metabolic remodeling in glioblastoma: A longitudinal multi-omics study","volume":"12","author":"Fontanilles","year":"2024","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_30","first-page":"477","article-title":"Early platelet variation during concomitant chemo-radiotherapy predicts adjuvant temozolomide-induced thrombocytopenia in newly diagnosed glioblastoma patients","volume":"27","author":"Fontanilles","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s40478-020-01057-7","article-title":"Cell-free DNA and circulating TERT promoter mutation for disease monitoring in newly-diagnosed glioblastoma","volume":"8","author":"Fontanilles","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40478-020-00917-6","article-title":"Simultaneous detection of EGFR amplification and EGFRvIII variant using digital PCR-based method in glioblastoma","volume":"8","author":"Fontanilles","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2017.03.035","article-title":"Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma","volume":"254","author":"Huang","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"NP95","DOI":"10.1177\/1533034615618834","article-title":"HIF-1alpha Inhibition Sensitized Pituitary Adenoma Cells to Temozolomide by Regulating Presenilin 1 Expression and Autophagy","volume":"15","author":"Kun","year":"2016","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_35","first-page":"1709","article-title":"Synergistic combination of chemo-phototherapy based on temozolomide\/ICG-loaded iron oxide nanoparticles for brain cancer treatment","volume":"42","author":"Kwon","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12929-025-01126-w","article-title":"IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment","volume":"32","author":"Lee","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.2147\/IJN.S310464","article-title":"Detection of PD-L1 Expression in Temozolomide-Resistant Glioblastoma by Using PD-L1 Antibodies Conjugated with Lipid-Coated Superparamagnetic Iron Oxide","volume":"16","author":"Lee","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"102451","DOI":"10.1016\/j.redox.2022.102451","article-title":"TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells","volume":"56","author":"Li","year":"2022","journal-title":"Redox Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13046-020-01641-8","article-title":"Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma","volume":"39","author":"Liu","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1039\/C7NJ04266C","article-title":"Anticarcinogenic and metal chelation properties of novel hydroxybenzylidene-1-indanone derivatives in the U-251 glioblastoma cell line","volume":"42","author":"Toscano","year":"2018","journal-title":"New J. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1158\/1535-7163.MCT-17-0022","article-title":"A Novel Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival","volume":"16","author":"Mohanty","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/acsptsci.2c00186","article-title":"Inhibition of Protein Disulfide Isomerase (PDIA1) Leads to Proteasome-Mediated Degradation of Ubiquitin-like PHD and RING Finger Domain-Containing Protein 1 (UHRF1) and Increased Sensitivity of Glioblastoma Cells to Topoisomerase II Inhibitors","volume":"6","author":"Mouawad","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"108289","DOI":"10.1016\/j.mtcomm.2024.108289","article-title":"Temozolomide loaded Fe3O4@SiO2 nanoparticles for MR-imaging directed synergistic therapy of glioblastoma multiforme in vitro","volume":"38","author":"Nozhat","year":"2024","journal-title":"Mater. Today Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11060-024-04571-z","article-title":"Iron-based biomarkers for personalizing pharmacological ascorbate therapy in glioblastoma: Insights from a phase 2 clinical trial","volume":"166","author":"Petronek","year":"2024","journal-title":"J. Neuro-Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1158\/1078-0432.CCR-22-3952","article-title":"Magnetic Resonance Imaging of Iron Metabolism with T2* Mapping Predicts an Enhanced Clinical Response to Pharmacologic Ascorbate in Patients with GBM","volume":"30","author":"Petronek","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1039\/C7NR00305F","article-title":"A polymeric temozolomide nanocomposite against orthotopic glioblastoma xenograft: Tumor-specific homing directed by nestin","volume":"9","author":"Prabhu","year":"2017","journal-title":"Nanoscale"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10532","DOI":"10.1038\/s41598-025-95544-3","article-title":"Magnetic hyperthermia therapy enhances the chemoradiosensitivity of glioblastoma","volume":"15","author":"Rivera","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"103101","DOI":"10.1016\/j.jddst.2022.103101","article-title":"Hydrolytic instability and low-loading levels of temozolomide to magnetic PLGA nanoparticles remain challenging against glioblastoma therapy","volume":"68","author":"Senturk","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e2402060","DOI":"10.1002\/adhm.202402060","article-title":"Tumoroid-On-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic Screening","volume":"14","author":"Seyfoori","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.3349\/ymj.2021.62.9.843","article-title":"Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells","volume":"62","author":"Song","year":"2021","journal-title":"Yonsei Med. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1158\/1078-0432.CCR-24-2974","article-title":"Olaparib, Temozolomide, and Concomitant Radiotherapy for Partially Resected or Biopsy-Only Glioblastoma First-Line Treatment: Results from the OLA-TMZ-RTE-01 Phase I Study","volume":"31","author":"Stefan","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Su, I.C., Su, Y.K., Setiawan, S.A., Yadav, V.K., Fong, I.H., Yeh, C.T., Lin, C.M., and Liu, H.W. (2023). NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2\/SOD2 Modulation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24097706"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"87","DOI":"10.7555\/JBR.38.20240100","article-title":"Cancer cell membrane-camouflaged biomimetic nanoparticles for enhancing chemo-radiation therapy efficacy in glioma","volume":"39","author":"Tang","year":"2024","journal-title":"J. Biomed. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2007166","DOI":"10.1002\/adfm.202007166","article-title":"siRNA nanoparticle suppresses drug-resistant gene and prolongs survival in an orthotopic glioblastoma xenograft mouse model","volume":"31","author":"Wang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/cai2.77","article-title":"The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide","volume":"2","author":"Wang","year":"2023","journal-title":"Cancer Innov."},{"key":"ref_56","first-page":"100800","article-title":"Implantation of hydrogel-liposome nanoplatform inhibits glioblastoma relapse by inducing ferroptosis","volume":"18","author":"Wang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40164-023-00468-1","article-title":"GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment","volume":"13","author":"Williams","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2843990","DOI":"10.1155\/2022\/2843990","article-title":"MicroRNA-147a Targets SLC40A1 to Induce Ferroptosis in Human Glioblastoma","volume":"2022","author":"Xu","year":"2022","journal-title":"Anal. Cell. Pathol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.bjp.0705687","article-title":"Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: Putative roles of hypoxia-inducible factor-1","volume":"141","author":"Yang","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"eadg5553","DOI":"10.1126\/scitranslmed.adg5553","article-title":"Reactivating PTEN to impair glioma stem cells by inhibiting cytosolic iron-sulfur assembly","volume":"16","author":"Yin","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zhu, H., Dai, C., He, L., Xu, A., and Chen, T. (2019). Iron (II) Polypyridyl Complexes as Antiglioblastoma Agents to Overcome the Blood-Brain Barrier and Inhibit Cell Proliferation by Regulating p53 and 4E-BP1 Pathways. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00946"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Abu-Serie, M.M., Osuka, S., Heikal, L.A., Teleb, M., Barakat, A., and Dudeja, V. (2024). Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: Aldehyde dehydrogenase 1A1 suppression and ferroptosis induction. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1363511"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41419-018-0864-7","article-title":"Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis","volume":"9","author":"Buccarelli","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/s41419-022-05044-9","article-title":"High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1\/MRP1 upregulation","volume":"13","author":"Monteiro","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8464817","DOI":"10.1155\/2024\/8464817","article-title":"Capsaicin Enhances Temozolomide-Resistant Glioblastoma Cells\u2019 Chemosensitivity and Ferroptosis through FHOD1\/IRF2 Downregulation","volume":"2024","author":"Hacioglu","year":"2024","journal-title":"J. Food Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"107377","DOI":"10.1016\/j.isci.2023.107377","article-title":"IRP1 mediated ferroptosis reverses temozolomide resistance in glioblastoma via affecting LCN2\/FPN1 signaling axis depended on NFKB2","volume":"26","author":"Lan","year":"2023","journal-title":"iScience"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/acs.bioconjchem.6b00545","article-title":"pH-Sensitive O6-Benzylguanosine Polymer Modified Magnetic Nanoparticles for Treatment of Glioblastomas","volume":"28","author":"Stephen","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1021\/nn503735w","article-title":"Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors","volume":"8","author":"Stephen","year":"2014","journal-title":"ACS Nano"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/s41419-022-05304-8","article-title":"HIF-alpha activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis","volume":"13","author":"Su","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"119342","DOI":"10.1016\/j.biomaterials.2019.119342","article-title":"Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide","volume":"218","author":"Sukumar","year":"2019","journal-title":"Biomaterials"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41374-022-00779-7","article-title":"Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain","volume":"102","author":"Yang","year":"2022","journal-title":"Lab. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s11307-014-0734-3","article-title":"Combination treatment with theranostic nanoparticles for glioblastoma sensitization to TMZ","volume":"16","author":"Yoo","year":"2014","journal-title":"Mol. Imaging Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1158\/0008-5472.CAN-24-1952","article-title":"Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity","volume":"85","author":"Talty","year":"2025","journal-title":"Cancer Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Liu, Y., Duan, C., Dai, R., and Zeng, Y. (2021). Ferroptosis-mediated Crosstalk in the Tumor Microenvironment Implicated in Cancer Progression and Therapy. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.739392"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Lin, Z., Zou, S., and Wen, K. (2023). The crosstalk of CD8+ T cells and ferroptosis in cancer. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1255443"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"102649","DOI":"10.1016\/j.omtn.2025.102649","article-title":"Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies","volume":"36","author":"Mashayekhi","year":"2025","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Hagiwara, F., Omata, D., Munakata, L., Kageyama, S., Maruyama, K., Kudo, N., and Suzuki, R. (2023). Brain Delivery of Cisplatin Using Microbubbles in Combination with Ultrasound as an Effective Therapy for Glioblastoma. Pharmaceuticals, 16.","DOI":"10.3390\/ph16111599"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/4\/194\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:35:51Z","timestamp":1775190951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/4\/194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":78,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["curroncol33040194"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33040194","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}