{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:13:34Z","timestamp":1792800814651,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM202211030"],"award-info":[{"award-number":["SZSM202211030"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Key Medical Discipline Construction Fund","award":["SZXK013"],"award-info":[{"award-number":["SZXK013"]}]},{"name":"Shenzhen Clinical Research Center for Cancer","award":["[2021]287"],"award-info":[{"award-number":["[2021]287"]}]},{"name":"Shenzhen High-level Hospital Construction Fund","award":["E010125001"],"award-info":[{"award-number":["E010125001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: An increasing number of reports showed patients with bulky tumors after lattice radiation therapy (LRT) treatment achieved good local control. However, in these reports, LRT was previously used primarily for palliation. We reported a case that LRT plays a synergistic role in the radical treatment of locally advanced bulky cervical cancer (LABCC) combined with INTERLACE study protocol. Methods: The patient was a 54-year-old female with LABCC and treated with LRT combined with the INTERLACE study protocol. She received three fractions of 3 Gy each to the gross tumor volume (GTV) and three fractions of 9 Gy each to the lattice therapy volume (LTV), on an emergent basis, using volumetric modulated arc therapy (VMAT). Subsequently, according to the INTERLACE study protocol, chemotherapy and radiotherapy were carried out and the standard follow-up examinations were conducted. Adverse events (AEs) were assessed according to the Common Terminology Criteria for AEs (CTCAE) version 5.0. Results: The patient initially received LRT, which reduced the tumor burden and controlled bleeding. After this was combined with the INTERLACE study protocol, the complete clinical response (cCR) was achieved and they maintained this status for 13 months after the completion of concurrent chemoradiotherapy (CCRT), with only manageable grade IV hematological toxicity observed after the completion of CCRT. During this period, only manageable grade IV hematological toxicity (platelet count 16 \u00d7 109\/L, white blood cell count 0.33 \u00d7 109\/L) was observed. Conclusions: In this case, LRT combined with INTERLACE study protocol appears to be a safe and effective for the treatment of LABCC which improved the patient\u2019s quality of life without uncontrolled treatment-related toxicity.<\/jats:p>","DOI":"10.3390\/curroncol33040196","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:09:18Z","timestamp":1774944558000},"page":"196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lattice Radiation Therapy Plays a Synergistic Role in the Radical Treatment of Bulky Cervical Cancer: A Case Report and Literature Review"],"prefix":"10.3390","volume":"33","author":[{"given":"Feifei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Family Relations and Applied Nutrition, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-689X","authenticated-orcid":false,"given":"Zhitao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-8246","authenticated-orcid":false,"given":"Zhijian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiugui","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: A worldwide analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/AOG.0000000000003311","article-title":"Prognostic Performance of the 2018 International Federation of Gynecology and Obstetrics Cervical Cancer Staging Guidelines","volume":"134","author":"Wright","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.6004\/jnccn.2023.0062","article-title":"NCCN Guidelines\u00ae Insights: Cervical Cancer, Version 1.2024: Featured Updates to the NCCN Guidelines","volume":"21","author":"Yashar","year":"2023","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.ijrobp.2008.03.054","article-title":"Preoperative concurrent radiation therapy and chemotherapy for bulky stage IB2, IIA, and IIB carcinoma of the uterine cervix with proximal parametrial invasion","volume":"72","author":"Huguet","year":"2008","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(24)01438-7","article-title":"Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): An international, multicentre, randomised phase 3 trial","volume":"404","author":"McCormack","year":"2024","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0140-6736(24)00317-9","article-title":"Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11\/GOG-3047\/KEYNOTE-A18): A randomised, double-blind, phase 3 clinical trial","volume":"403","author":"Lorusso","year":"2024","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0140-6736(24)01808-7","article-title":"Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11\/GOG-3047\/KEYNOTE-A18): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"404","author":"Lorusso","year":"2024","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ijrobp.2025.04.037","article-title":"Distant Metastasis After Chemoradiation and Image Guided Adaptive Brachytherapy in Locally Advanced Cervical Cancer","volume":"123","author":"Knoth","year":"2025","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ferini, G., Valenti, V., Tripoli, A., Illari, S.I., Molino, L., Parisi, S., Cacciola, A., Lillo, S., Giuffrida, D., and Pergolizzi, S. (2021). Lattice or Oxygen-Guided Radiotherapy: What If They Converge? Possible Future Directions in the Era of Immunotherapy. Cancers, 13.","DOI":"10.3390\/cancers13133290"},{"key":"ref_10","first-page":"100569","article-title":"Lattice radiation therapy in clinical practice: A systematic review","volume":"39","author":"Iori","year":"2023","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.ijrobp.2011.01.065","article-title":"High-Dose Spatially Fractionated GRID Radiation Therapy (SFGRT): A Comparison of Treatment Outcomes With Cerrobend vs. MLC SFGRT","volume":"82","author":"Neuner","year":"2012","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_12","first-page":"e389","article-title":"The use of lattice radiation therapy (LRT) in the treatment of bulky tumors: A case report of a large metastatic mixed mullerian ovarian tumor","volume":"7","author":"Amendola","year":"2015","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijrobp.2019.01.073","article-title":"A Current Review of Spatial Fractionation: Back to the Future?","volume":"104","author":"Billena","year":"2019","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jiang, L., Li, X., Zhang, J., Li, W., Dong, F., Chen, C., Lin, Q., Zhang, C., Zheng, F., and Yan, W. (2020). Combined high-dose LATTICE radiation therapy and immune checkpoint blockade for advanced bulky tumors: The concept and a case report. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.548132"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e010581","DOI":"10.1136\/jitc-2024-010581","article-title":"XCL1-secreting CEA CAR-T cells enhance endogenous CD8+ T cell responses to tumor neoantigens to confer a long-term antitumor immunity","volume":"13","author":"Li","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1667\/RADE-20-00065.1","article-title":"Evidence for early stage anti-tumor immunity elicited by spatially fractionated radiotherapy-immunotherapy combinations","volume":"194","author":"Johnsrud","year":"2020","journal-title":"Radiat. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.radonc.2021.11.023","article-title":"LITE SABR M1: A phase I trial of lattice stereotactic body radiotherapy for large tumors","volume":"167","author":"Duriseti","year":"2022","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6437","DOI":"10.1158\/1078-0432.CCR-20-1790","article-title":"Improved survival associated with local tumor response following multisite radiotherapy and pembrolizumab: Secondary analysis of a phase I trial","volume":"26","author":"Luke","year":"2020","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1667\/RADE-20-00066.1","article-title":"The technical and clinical implementation of LATTICE radiation therapy (LRT)","volume":"194","author":"Wu","year":"2020","journal-title":"Radiat. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijrobp.2021.09.027","article-title":"A story of hypofractionation and the table on the wall","volume":"112","author":"Timmerman","year":"2022","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative analyses of normal tissue effects in the clinic (QUANTEC): An introduction to the scientific issues","volume":"76","author":"Bentzen","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_22","unstructured":"(2013). International Commission on Radiation Units and Measurements in collaboration with Groupe Europeen de Curietherapie-European Society for Radiotherapy and Oncology. Prescribing, recording, and reporting brachytherapy for cancer of the cervix. J. ICRU, 13, NP."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e14469","DOI":"10.1002\/acm2.14469","article-title":"Dosimetric impact of intrafraction patient motion on MLC-based 3D-conformal spatially fractionated radiation therapy treatment of large and bulky tumors","volume":"25","author":"Misa","year":"2024","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ijrobp.2023.12.013","article-title":"Overview and recommendations for prospective multi-institutional spatially fractionated radiation therapy clinical trials","volume":"119","author":"Li","year":"2024","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.21037\/apm-22-246","article-title":"How a very large sarcomatoid lung cancer was efficiently managed with lattice radiation therapy: A case report","volume":"11","author":"Iori","year":"2022","journal-title":"Ann. Palliat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Liu, X., Xu, K., Yao, Q., Fang, J., Zhou, W., and Lang, J. (2025). Metastatic colon adenocarcinoma to the gingiva treated with spatial fractionation radiotherapy: A case report. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1580430"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Iati\u2019, G., Parisi, S., Ferrantelli, G., and Pergolizzi, S. (2025). Metabolism-guided LATTICE radiotherapy in an elderly patient with locally advanced head and neck cancer treated with curative aim: A case report. Reports, 8.","DOI":"10.20944\/preprints202509.0329.v1"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hobson, J., Grams, M.P., Gicobi, J.K., Wigle, D., Kottschade, L.A., Durham, L.A., Corbin, K., Dong, H., Markovic, S.N., and Park, S.S. (2025). Case report: Complete pathologic response in advanced melanoma with SFRT and dual checkpoint inhibition. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1697902"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.ijrobp.2023.01.002","article-title":"Overall severe morbidity after chemo-radiation therapy and magnetic resonance imaging-guided adaptive brachytherapy in locally advanced cervical cancer: Results from the EMBRACE-I study","volume":"116","author":"Vittrup","year":"2023","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100222","DOI":"10.1016\/j.tipsro.2023.100222","article-title":"Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report","volume":"28","author":"Saito","year":"2023","journal-title":"Tech. Innov. Patient Support Radiat. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/jmp.JMP_38_17","article-title":"Grid block design based on monte carlo simulated dosimetry, the linear quadratic and hug\u2013kellerer radiobiological models","volume":"42","author":"Nedaie","year":"2017","journal-title":"J. Med. Phys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.ijrobp.2025.06.3901","article-title":"Feasibility study of functional magnetic resonance imaging-based biologically-guided lattice radiotherapy","volume":"123","author":"Yuan","year":"2025","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Ferini, G., Parisi, S., Lillo, S., Viola, A., Minutoli, F., Critelli, P., Valenti, V., Illari, S.I., Brogna, A., and Umana, G.E. (2022). Impressive results after \u201cmetabolism-guided\u201d lattice irradiation in patients submitted to palliative radiation therapy: Preliminary results of LATTICE_01 multicenter study. Cancers, 14.","DOI":"10.3390\/cancers14163909"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1016\/j.ijrobp.2023.06.054","article-title":"Dose painting radiotherapy guided by diffusion-weighted magnetic resonance vs. 18F-FDG-PET\/CT in locoregionally advanced nasopharyngeal carcinoma: A randomized, controlled clinical trial","volume":"117","author":"Liu","year":"2023","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_35","first-page":"29","article-title":"Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy","volume":"13","author":"Leibfarth","year":"2018","journal-title":"Clin. Transl. Radiat. Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/4\/196\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T04:12:51Z","timestamp":1775103171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/4\/196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["curroncol33040196"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33040196","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}