{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:02:06Z","timestamp":1792789326264,"version":"4.5.0"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008730","name":"Norwegian Cancer Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Liaison Committee for Education, Research and Innovation in Central Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Undernutrition and cachexia are common in advanced cancer and often linked to systemic inflammation. While inflammation is associated with poorer prognosis, accelerated weight loss, and reduced treatment tolerance, its direct impact on food intake remains insufficiently investigated. Aim: To examine the association between systemic inflammation and energy and protein intake over time in patients with advanced cancer. Methods: A total of 170 patients from the Palliative Radiotherapy and Inflammation Study were included. Nutritional status was assessed using PG-SGA SF. Dietary intake was recorded using repeated 24 h recalls. Systemic inflammation was defined as CRP &gt; 10 mg\/L. Mixed linear models were applied to evaluate the association between inflammation energy and protein intake over time. Results: Systemic inflammation (CRP &gt;10 mg\/L) was present in 87 (51%) patients and associated with significantly lower energy (\u22123.6 kcal\/kg, p = 0.04) and lower protein intake (\u22120.25 g\/kg, p = 0.003). Patients with inflammation were more often undernourished and had shorter survival. Conclusions: Systemic inflammation is likely associated with clinically relevant reductions in energy and protein intake in advanced cancer. CRP may help identify patients for whom standard nutritional support is insufficient.<\/jats:p>","DOI":"10.3390\/curroncol33040209","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:25:12Z","timestamp":1775633112000},"page":"209","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Linking Inflammation to Reduced Food Intake in Advanced Cancer: A Prospective Observational Study"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-0240","authenticated-orcid":false,"given":"Asta","family":"Bye","sequence":"first","affiliation":[{"name":"Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet\u2014Oslo Metropolitan University, 0130 Oslo, Norway"},{"name":"European Palliative Care Research Centre (PRC), Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-4268","authenticated-orcid":false,"given":"Trude Rakel","family":"Balstad","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU\u2014Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Department of Clinical Medicine, Clinical Nutrition Research Group, UiT The Arctic University of Norway, 9019 Tromso, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Ervik Raaness","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine and Dentistry, University of Bergen, 5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-8437","authenticated-orcid":false,"given":"Tora Skeidsvoll","family":"Solheim","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU\u2014Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Cancer Clinic, St. Olavs Hospital-Trondheim University Hospital, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild","family":"Habberstad","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU\u2014Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Cancer Clinic, St. Olavs Hospital-Trondheim University Hospital, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Klepstad","sequence":"additional","affiliation":[{"name":"Department of Circulation and Medical Imaging, NTNU\u2014Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Department of Anesthesiology and Intensive Care Medicine, St. Olavs Hospital-Trondheim University Hospital, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Torbj\u00f8rn","family":"L\u00f8hre","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU\u2014Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Cancer Clinic, St. Olavs Hospital-Trondheim University Hospital, 7006 Trondheim, Norway"},{"name":"Centre for Crisis Psychology, Faculty of Psychology, University of Bergen, 5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9115-8529","authenticated-orcid":false,"given":"Olav Faisal","family":"Dajani","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre (PRC), Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway"},{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, University of Oslo, 0318 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre (PRC), Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway"},{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, University of Oslo, 0318 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Aass","sequence":"additional","affiliation":[{"name":"European Palliative Care Research Centre (PRC), Department of Oncology, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, 0424 Oslo, Norway"},{"name":"Regional Advisory Unit for Palliative Care, Department of Oncology, Oslo University Hospital, University of Oslo, 0318 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-5969","authenticated-orcid":false,"given":"Ola Magne","family":"Vagnildhaug","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU\u2014Norwegian University of Science and Technology, 7491 Trondheim, Norway"},{"name":"Cancer Clinic, St. Olavs Hospital-Trondheim University Hospital, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41430-024-01433-9","article-title":"Malnutrition, sarcopenia and cachexia: Exploring prevalence, overlap, and perceptions in older adults with 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