{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:03:12Z","timestamp":1776679392257,"version":"3.51.2"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of neurotoxic chemotherapy that can affect functioning and quality of life. Currently, duloxetine is the only recommended agent to treat painful CIPN; however, no effective pharmacological treatments have been approved for the prevention or cure of CIPN, highlighting the need to understand non-pharmacological strategies such as exercise. Given significant heterogeneity in the CIPN outcome measures chosen across studies, this scoping review aimed to identify the outcome measures used to evaluate the effectiveness of exercise interventions as a potential countermeasure for CIPN. Following the Arksey and O\u2019Malley framework refined by Levac and colleagues, and the PRISMA-ScR guidelines, four databases were searched, and 20 studies were included in the review. Data were abstracted on study characteristics, cancer and chemotherapy factors, exercise prescription, outcome measures, and CIPN-related findings. Outcome measures varied widely across studies, encompassing various patient-reported, clinical, and functional measures. The most common patient-reported, clinical, and functional measures were the EORTC QLQ-CIPN20, vibration sensation, and maximal isometric strength, respectively. No study satisfied the components of the core outcome measure set proposed by Park and colleagues, limiting cross-study comparisons. These findings underscore the need for standardized CIPN outcome measures in future exercise studies to strengthen evidence synthesis and inform clinical practice.<\/jats:p>","DOI":"10.3390\/curroncol33040231","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:24:23Z","timestamp":1776673463000},"page":"231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcome Measures to Assess the Effectiveness of Exercise Interventions on Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Scoping Review"],"prefix":"10.3390","volume":"33","author":[{"given":"Trei R.","family":"Lindstrom","sequence":"first","affiliation":[{"name":"Faculty of Rehabilitation Medicine, University of Alberta, 2-50  Corbett Hall, Edmonton, AB T6G 2G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna F.","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Faculty of Rehabilitation Medicine, University of Alberta, 2-50  Corbett Hall, Edmonton, AB T6G 2G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9677-3918","authenticated-orcid":false,"given":"Kerry S.","family":"Courneya","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology, Sport, and Recreation, University of Alberta, 1-113 University Hall, Edmonton, AB T6G 2H9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-4847","authenticated-orcid":false,"given":"Margaret L.","family":"McNeely","sequence":"additional","affiliation":[{"name":"Faculty of Rehabilitation Medicine, University of Alberta, 2-50  Corbett Hall, Edmonton, AB T6G 2G4, Canada"},{"name":"Department of Oncology, Cancer Care Alberta, Edmonton, AB T6G 1Z2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref_1","first-page":"426","article-title":"The Effects of Exercise on Symptoms of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Systematic Review and Meta-Analysis","volume":"51","author":"Khmethong","year":"2024","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"D\u2019Souza, R.S., Saini, C., Hussain, N., Javed, S., Prokop, L., and Her, Y.F. (2025). Global Estimates of Prevalence of Chronic Painful Neuropathy and Moderate-to-Severe Neuropathy among Patients with Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Data from 29 Countries between 2000 and 2024. Reg. Anesth. Pain Med., Epub ahead of printing.","DOI":"10.1136\/rapm-2024-106229"},{"key":"ref_3","first-page":"4223","article-title":"Chemotherapy-Induced Peripheral Neuropathy (CIPN): Current Therapies and Topical Treatment Option with High-Concentration Capsaicin","volume":"29","author":"Diel","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1200\/JCO.20.01399","article-title":"Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update","volume":"38","author":"Loprinzi","year":"2020","journal-title":"JCO J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Nakagawa, N., Yamamoto, S., Hanai, A., Oiwa, A., and Arao, H. (2024). Exercise Intervention for the Management of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Network Meta-Analysis. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1346099"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/sms.14360","article-title":"Effects of Exercise Interventions to Reduce Chemotherapy-Induced Peripheral Neuropathy Severity: A Meta-Analysis","volume":"33","year":"2023","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Huang, Y., Tan, T., Liu, L., Yan, Z., Deng, Y., Li, G., Li, M., and Xiong, J. (2024). Exercise for Reducing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1252259"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/14737175.2022.2018300","article-title":"Optimal Outcome Measures for Assessing Exercise and Rehabilitation Approaches in Chemotherapy-Induced Peripheral-Neurotoxicity: Systematic Review and Consensus Expert Opinion","volume":"22","author":"Park","year":"2022","journal-title":"Expert. Rev. Neurother."},{"key":"ref_9","unstructured":"Portney, L.G., and Watkins, M.P. (2009). Foundations of Clinical Research: Applications to Practice, Pearson Education, Inc.. [3rd ed.]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping Studies: Towards a Methodological Framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol. Theory Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping Studies: Advancing the Methodology","volume":"5","author":"Levac","year":"2010","journal-title":"Implement. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_13","first-page":"126","article-title":"Physical Activity, Exercise, and Physical Fitness: Definitions and Distinctions for Health-Related Research","volume":"100","author":"Caspersen","year":"1985","journal-title":"Public. Health Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater Reliability: The Kappa Statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem. Med."},{"key":"ref_15","first-page":"95","article-title":"Strength and Endurance Training in the Treatment of Lung Cancer Patients in Stages IIIA\/IIIB\/IV","volume":"22","author":"Henke","year":"2014","journal-title":"Support. Care Cancer"},{"key":"ref_16","first-page":"615","article-title":"Eight-Week, Multimodal Exercise Counteracts a Progress of Chemotherapy-Induced Peripheral Neuropathy and Improves Balance and Strength in Metastasized Colorectal Cancer Patients: A Randomized Controlled Trial","volume":"26","author":"Zimmer","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_17","first-page":"2159","article-title":"Exercise Improves Functional Capacity and Lean Body Mass in Patients with Gastrointestinal Cancer during Chemotherapy: A Single-Blind RCT","volume":"27","author":"Stuecher","year":"2019","journal-title":"Support. Care Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kneis, S., Wehrle, A., M\u00fcller, J., Maurer, C., Ihorst, G., Gollhofer, A., and Bertz, H. (2019). It\u2019s Never Too Late\u2014Balance and Endurance Training Improves Functional Performance, Quality of Life, and Alleviates Neuropathic Symptoms in Cancer Survivors Suffering from Chemotherapy-Induced Peripheral Neuropathy: Results of a Randomized Controlled Trial. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5522-7"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/s41416-021-01471-1","article-title":"Preventive Effect of Sensorimotor Exercise and Resistance Training on Chemotherapy-Induced Peripheral Neuropathy: A Randomised-Controlled Trial","volume":"125","author":"Weiler","year":"2021","journal-title":"Br. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/acn3.51426","article-title":"Type of Exercise May Influence Postural Adaptations in Chemotherapy-Induced Peripheral Neuropathy","volume":"8","author":"Waibel","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_21","first-page":"970","article-title":"Effects on Chemotherapy-Induced Peripheral Neuropathy by Moderate Strength Training in Combination with Whole-Body Vibration in Breast Cancer Patients","volume":"33","author":"Dalferth","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_22","first-page":"1019","article-title":"Effects of Exercise during Chemotherapy on Chemotherapy-Induced Peripheral Neuropathy: A Multicenter, Randomized Controlled Trial","volume":"26","author":"Kleckner","year":"2018","journal-title":"Support. Care Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E531","DOI":"10.1097\/NCC.0000000000001003","article-title":"Efficacy of the Motivational Interviewing-Walk Intervention for Chemotherapy-Induced Peripheral Neuropathy and Quality of Life During Oxaliplatin Treatment: A Pilot Randomized Controlled Trial","volume":"45","author":"Larson","year":"2022","journal-title":"Cancer Nurs."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s13063-022-06294-w","article-title":"Assessing Gait, Balance, and Muscle Strength among Breast Cancer Survivors with Chemotherapy-Induced Peripheral Neuropathy (CIPN): Study Protocol for a Randomized Controlled Clinical Trial","volume":"23","author":"Haladay","year":"2022","journal-title":"Trials"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e2326463","DOI":"10.1001\/jamanetworkopen.2023.26463","article-title":"Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer: A Secondary Analysis of a Randomized Clinical Trial","volume":"6","author":"Cao","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_26","first-page":"677","article-title":"Pilot Trial Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neurotoxicity (CIPN) and the Interoceptive Brain System","volume":"32","author":"Kleckner","year":"2024","journal-title":"Support Care Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Manuweera, T., Wagenknecht, A., Rosales, J., Baechler, C., Chung, K.H., Clingan, C.L., Kleckner, A.S., Rosenblatt, P.Y., Ciner, A., and Zhu, S. (2026, January 15). Protocols for Two Phase Ii Randomized Controlled Trials Testing the Effects of Exercise on Chemotherapy-Induced Peripheral Neurotoxicity (Cipn) and the Interoceptive Brain Circuitry in Patients with Breast or Gastrointestinal Cancers. Available online: https:\/\/ssrn.com\/abstract=5122547.","DOI":"10.2139\/ssrn.5122547"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4103\/apjon.apjon-2075","article-title":"Cold Application and Exercise on Development of Peripheral Neuropathy during Taxane Chemotherapy in Breast Cancer Patients: A Randomized Controlled Trial","volume":"8","author":"Demir","year":"2021","journal-title":"Asia Pac. J. Oncol. Nurs."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"102974","DOI":"10.1016\/j.ejon.2025.102974","article-title":"The Impact of Walking Exercise Guided by the Theory of Unpleasant Symptoms on Peripheral Neuropathy and Arthralgia-Myalgia in Breast Cancer Patients Undergoing Paclitaxel Treatment: A Randomized Controlled Trial","volume":"78","author":"Ozdemir","year":"2025","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1016\/j.cllc.2025.07.005","article-title":"The Effect of Exercise on Quality of Life in Patients With Advanced Lung Cancer: A Secondary Analysis of a Randomized Controlled Trial","volume":"26","author":"Bloch","year":"2025","journal-title":"Clin. Lung Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.clbc.2019.05.013","article-title":"Effect of Exercise on Taxane Chemotherapy-Induced Peripheral Neuropathy in Women With Breast Cancer: A Randomized Controlled Trial","volume":"19","author":"Bland","year":"2019","journal-title":"Clin. Breast Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/NCC.0000000000000693","article-title":"A Randomized Controlled Trial to Assess the Effectiveness of Muscle Strengthening and Balancing Exercises on Chemotherapy-Induced Peripheral Neuropathic Pain and Quality of Life Among Cancer Patients","volume":"43","author":"Dhawan","year":"2020","journal-title":"Cancer Nurs."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Martin-Sanchez, C., Fern\u00e1ndez-Rodr\u00edguez, E.J., Lopez-Mateos, Y., Garcia-Martin, A., Fonseca-Sanchez, E., and S\u00e1nchez-Gonz\u00e1lez, J.L. (2024). Effects of a Resistance Exercise Program in Patients with Colorectal Cancer Undergoing Chemotherapy Treatment: A Randomized Controlled Trial Study Protocol. J. Clin. Med., 13.","DOI":"10.3390\/jcm13154478"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.1097\/NCC.0000000000001322","article-title":"The Effects of an App-Based Physical Activity Program on Colorectal Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial","volume":"48","author":"Hwang","year":"2025","journal-title":"Cancer Nurs."},{"key":"ref_35","first-page":"33","article-title":"Systematic Review of Long-Term Chemotherapy-Induced Peripheral Neuropathy (CIPN) Following Adjuvant Oxaliplatin for Colorectal Cancer","volume":"30","author":"Teng","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1212\/WNL.0000000000004272","article-title":"Chemotherapy-Induced Peripheral Neuropathy Clinical Trials: Review and Recommendations","volume":"89","author":"Gewandter","year":"2017","journal-title":"Neurology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3402108","DOI":"10.1155\/2020\/3402108","article-title":"A Simplified Diagnostic Classification Scheme of Chemotherapy-Induced Peripheral Neuropathy","volume":"2020","author":"Huang","year":"2020","journal-title":"Dis. Markers"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Bland, K.A., Neil-Sztramko, S.E., Zadravec, K., Medysky, M.E., Kong, J., Winters-Stone, K.M., and Campbell, K.L. (2022). Correction to: Attention to Principles of Exercise Training: An Updated Systematic Review of Randomized Controlled Trials in Cancers Other than Breast and Prostate. BMC Cancer, 22.","DOI":"10.1186\/s12885-021-09022-w"},{"key":"ref_39","first-page":"1042","article-title":"Attention to the Principles of Exercise Training in Exercise Studies of Persons With Lung Cancer: A Systematic Review","volume":"29","author":"Medysky","year":"2021","journal-title":"J. Aging Phys. Act."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.annonc.2020.07.003","article-title":"Systemic Anticancer Therapy-Induced Peripheral and Central Neurotoxicity: ESMO\u2013EONS\u2013EANO Clinical Practice Guidelines for Diagnosis, Prevention, Treatment and Follow-Up","volume":"31","author":"Jordan","year":"2020","journal-title":"Ann. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chung, K.H., Park, S.B., Streckmann, F., Wiskemann, J., Mohile, N., Kleckner, A.S., Colloca, L., Dorsey, S.G., and Kleckner, I.R. (2022). Mechanisms, Mediators, and Moderators of the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy. Cancers, 14.","DOI":"10.3390\/cancers14051224"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22278","DOI":"10.1002\/cam4.6753","article-title":"Updated Systematic Review of the Effects of Exercise on Understudied Health Outcomes in Cancer Survivors","volume":"12","author":"Sturgeon","year":"2023","journal-title":"Cancer Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lee, K.T., Bulls, H.W., Hoogland, A.I., James, B.W., Colon-Echevarria, C.B., and Jim, H.S.L. (2024). Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Narrative Review and Proposed Theoretical Model. Cancers, 16.","DOI":"10.3390\/cancers16142571"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Starobova, H., and Vetter, I. (2017). Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy. Front. Mol. Neurosci., 10.","DOI":"10.3389\/fnmol.2017.00174"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/4\/231\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:18:24Z","timestamp":1776676704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/4\/231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":45,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["curroncol33040231"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33040231","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}