{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:09:04Z","timestamp":1778519344469,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: High-grade glioma (HGG), formerly known as Glioblastoma multiforme, can be complicated by hematomas, either at the initial presentation or after surgical removal. Rarely, postoperative bleeding can occur extra-axially, resulting in subdural hematomas (SDH) that might require surgical evacuation. Of note, little is known about the cellular composition of those hematomas. Observations: We present the case of a patient operated on for HGG who developed postoperative recurrent SDH that required multiple surgical evacuations. Histopathological analyses of the membranes comprising the SDH revealed the presence of HGG tumoral cells. Conclusions: Based on our observation, hematomas associated with HGG, either extra or intra-axial, should be suspected of being a sign of tumoral recurrence or spread and histopathological analyses might be considered as they could lead to further adaptation of the patient\u2019s treatment.<\/jats:p>","DOI":"10.3390\/curroncol33050283","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:39:32Z","timestamp":1778513972000},"page":"283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-Grade Glioma Tumoral Cells in a Case of Postoperative, Recurrent Subdural Hematoma\u2026 Where Did They Come From?"],"prefix":"10.3390","volume":"33","author":[{"given":"Paul E.","family":"Constanthin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Geneva University Hospitals (HUG), 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva (UNIGE), 1205 Geneva, Switzerland"},{"name":"Department of Neurosurgery, Pellegrin Hospital, Bordeaux University Hospital, 33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Durouchoux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Pellegrin Hospital, Bordeaux University Hospital, 33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Jannelli","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Geneva University Hospitals (HUG), 1205 Geneva, Switzerland"},{"name":"Faculty of Medicine, University of Geneva (UNIGE), 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9gane","family":"Le Quang","sequence":"additional","affiliation":[{"name":"Pathology Department, Bordeaux University Hospital, 33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0992-1597","authenticated-orcid":false,"given":"Guillaume","family":"Chotard","sequence":"additional","affiliation":[{"name":"Pathology Department, Bordeaux University Hospital, 33000 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Engelhardt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Pellegrin Hospital, Bordeaux University Hospital, 33000 Bordeaux, France"},{"name":"Institute of Cellular Biochemistry and Genetics, CNRS UMR 5095, Bordeaux University, 33076 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015\u20132019","volume":"24","author":"Ostrom","year":"2022","journal-title":"Neuro-Oncology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/bpa.12171","article-title":"International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading","volume":"24","author":"Louis","year":"2014","journal-title":"Brain Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2013\u20132017","volume":"22","author":"Ostrom","year":"2020","journal-title":"Neuro-Oncology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1227\/00006123-198204000-00004","article-title":"Spontaneous Intracranial Hemorrhage Caused by Brain Tumor: Its Incidence and Clinical Significance","volume":"10","author":"Wakai","year":"1982","journal-title":"Neurosurgery"},{"key":"ref_5","first-page":"e14212","article-title":"Lion in Sheep\u2019s Clothing: Glioblastoma Mimicking Intracranial Hemorrhage","volume":"13","author":"Broka","year":"2021","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"bcr2018224929","DOI":"10.1136\/bcr-2018-224929","article-title":"Chronic Calcified Subdural Haematoma Found after Presentation of Symptomatic Glioma","volume":"2018","author":"Chan","year":"2018","journal-title":"BMJ Case Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1080\/02688697.2020.1866747","article-title":"Giant Cell Glioblastoma Multiforme Presents as Acute Pathological Nontraumatic Subdural Haematoma","volume":"37","author":"Dajani","year":"2023","journal-title":"Br. 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