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Delayed diagnoses, limited therapeutic options, and lack of safety data exacerbate the clinical challenges of treating cancer during pregnancy. Further, the biology of gestational cancers is poorly understood due to the scarcity of model systems and mechanistic studies. This manuscript presents a multidisciplinary perspective from a group of researchers and clinicians to evaluate the current state of pregnancy-associated cancers, identify unmet clinical and biological questions, and propose strategies to improve diagnosis, treatment, and maternal\u2013fetal outcomes.<\/jats:p>","DOI":"10.3390\/curroncol33050296","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:53:10Z","timestamp":1779191590000},"page":"296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cancer During Pregnancy: Navigating Clinical and Research Challenges"],"prefix":"10.3390","volume":"33","author":[{"given":"Mackenzie K.","family":"Callaway","sequence":"first","affiliation":[{"name":"Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, 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