{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T11:07:25Z","timestamp":1779966445560,"version":"3.53.1"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Minimally invasive surgery is widely used in endometrial cancer management, but recurrence remains a concern. Methods: A retrospective review of 1201 patients treated from 2012 to 2019 with robotic laparoscopy was conducted. Recurrence-free survival and hazard ratios were calculated using multivariate Cox models. Results: Of 1278 patients, 155 cases of recurrent disease were identified. Age (HR 1.01, p = 0.045), LVSI (HR 3.54, p &lt; 0.001), stage and high-grade histology (HR 3.39, p &lt; 0.001) were associated with increased risk of recurrence. Hazard ratios for stages IB, II and III\/IV were 1.92 (p = 0.007), 2.67 (p = 0.001), and 3.23 (p &lt; 0.001) respectively. The use of a uterine manipulator was an independent risk factor on multivariate analysis (HR 2.12, p &lt; 0.001). Adjuvant chemotherapy (HR 0.67, p = 0.239) and radiotherapy (HR 0.64, p = 0.056) trends favored reduced risk but were not significant. Chemoradiotherapy was found to have a reduction in recurrence with a HR 0.44 (p = 0.002). Conclusions: Traditional prognostic factors remain important for patients with endometrial cancer having undergone robotic laparoscopic hysterectomy. Uterine manipulator use should be carefully reconsidered in endometrial cancer surgery.<\/jats:p>","DOI":"10.3390\/curroncol33060317","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T09:57:43Z","timestamp":1779962263000},"page":"317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial Cancer Recurrence Risk Following Robotic Hysterectomy"],"prefix":"10.3390","volume":"33","author":[{"given":"Sean","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cumming School of Medicine, University of Calgary, Foothills Medical Centre, 1403 29 Street NW, Calgary, AB T2N 2T9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Cross Cancer Institute, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7267-7428","authenticated-orcid":false,"given":"Haley","family":"Frerichs","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, University of Alberta, Walter C. Mackenzie Health Sciences Centre, 8440 112 Street NW, Edmonton, AB T6G 2R7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, University of Alberta, Walter C. Mackenzie Health Sciences Centre, 8440 112 Street NW, Edmonton, AB T6G 2R7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Gill","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, University of Alberta, Walter C. Mackenzie Health Sciences Centre, 8440 112 Street NW, Edmonton, AB T6G 2R7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab Al","family":"Habsi","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Cross Cancer Institute, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Beruar","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Cross Cancer Institute, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-044X","authenticated-orcid":false,"given":"Sophia","family":"Pin","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, University of Alberta, Cross Cancer Institute, 11560 University Avenue NW, Edmonton, AB T6G 1Z2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries, CA","volume":"71","author":"Sung","year":"2021","journal-title":"Cancer J. 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