{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:01:39Z","timestamp":1780081299833,"version":"3.54.0"},"reference-count":16,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical Science and Technology Development Foundation, Nanjing Department of Health","award":["ZKX24021"],"award-info":[{"award-number":["ZKX24021"]}]},{"name":"Medical Research Project of Jiangsu Provincial Health Commission","award":["K2024038"],"award-info":[{"award-number":["K2024038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Solitary fibrous tumor\/hemangiopericytoma (SFT\/HPC) of the central nervous system is a rare mesenchymal neoplasm with a propensity for late recurrence and distant metastasis. Pancreatic metastasis from intracranial SFT\/HPC is exceptionally uncommon and may mimic primary pancreatic neoplasms, particularly pancreatic neuroendocrine tumor (PanNET). We report a 52-year-old man with a documented history of recurrent intracranial SFT\/HPC, historically diagnosed as hemangiopericytoma, who developed a hypervascular pancreatic tail lesion 11 years after the initial intracranial tumor diagnosis. Contrast-enhanced imaging and endoscopic ultrasound-guided fine-needle aspiration initially suggested a primary pancreatic neoplasm, including solid pseudopapillary neoplasm or PanNET, and a definitive preoperative diagnosis could not be established. Following laparoscopic resection, histopathological examination revealed a spindle-cell tumor with a rich vascular pattern. Immunohistochemistry documented STAT6 positivity, together with vimentin and Bcl-2 positivity, supporting the diagnosis of pancreatic metastasis from SFT\/HPC. The patient later developed unresectable recurrent pancreatic disease and underwent stereotactic radiotherapy, showing radiological disease control at follow-up. This case highlights that pancreatic metastasis from intracranial SFT\/HPC, although extremely rare, may occur after a prolonged latency period and mimic a hypervascular primary pancreatic neoplasm. In patients with a history of intracranial SFT\/HPC, late metastatic disease should be considered, and definitive diagnosis relies on histopathological examination and targeted immunohistochemistry.<\/jats:p>","DOI":"10.3390\/curroncol33060323","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:36:18Z","timestamp":1780076178000},"page":"323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pancreatic Metastasis from Intracranial Solitary Fibrous Tumor\/Hemangiopericytoma Mimicking a Pancreatic Neuroendocrine Tumor: A Case Report and Focused Literature Review"],"prefix":"10.3390","volume":"33","author":[{"given":"Xiang","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China"},{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Tong","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochen","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizi","family":"Sha","sequence":"additional","affiliation":[{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Jiangsu University, Nanjing 210008, China"},{"name":"The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 Who Classification of Tumors of the Central Nervous System: A Summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A Summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00401-013-1117-6","article-title":"Meningeal Hemangiopericytoma and Solitary Fibrous Tumors Carry the Nab2-Stat6 Fusion and Can Be Diagnosed by Nuclear Expression of Stat6 Protein","volume":"125","author":"Schweizer","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00428-004-0987-3","article-title":"Secondary Tumors of the Pancreas: An Analysis of a Surgical and Autopsy Database and Review of the Literature","volume":"444","author":"Adsay","year":"2004","journal-title":"Virchows Arch."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1046\/j.1440-1827.2001.01258.x","article-title":"Secondary Tumors of the Pancreas: Clinicopathological Study of 103 Autopsy Cases of Japanese Patients","volume":"51","author":"Nakamura","year":"2001","journal-title":"Pathol. 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