{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:53:08Z","timestamp":1781693588889,"version":"3.54.5"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background: Gestational trophoblastic neoplasia (GTN) is rare but highly curable. This study compared clinical characteristics and outcomes between molar and non-molar disease. Methods: This retrospective cohort included 550 patients at a Brazilian reference center (1985\u20132025). Survival was assessed using Kaplan\u2013Meier methods. Multivariable analyses included Poisson and Cox regression models. Results: Molar GTN comprised 86% of cases. Non-molar GTN (14%) presented with more advanced FIGO stages, higher WHO risk scores, and more metastases (p &lt; 0.001). Overall five-year disease-specific survival (DSS) was 97.4% (95% CI 95.9\u201398.9) and progression-free survival (PFS) was 92.4% (95% CI 90.1\u201394.7). Non-molar disease had lower DSS (84.4% vs. 99.8%; p &lt; 0.001) and PFS (85.3% vs. 93.5%; p = 0.049) in unadjusted analyses. However, after multivariable adjustment, GTN type was not independently associated with DSS (HR 9.41; 95% CI 0.70\u2013127; p = 0.092) or PFS (HR 1.61; 95% CI 0.57\u20134.60; p = 0.372). Non-molar patients had a lower likelihood of subsequent pregnancy (RR 0.60; 95% CI 0.36\u20131.00; p = 0.049). Conclusions: Although non-molar GTN presents with more aggressive clinical features, survival outcomes appear to be primarily driven by baseline disease severity rather than GTN subtype itself.<\/jats:p>","DOI":"10.3390\/curroncol33060352","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:14:58Z","timestamp":1781180098000},"page":"352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational Trophoblastic Neoplasia Following Hydatidiform Mole and Non-Molar Pregnancy: Clinical and Prognostic Features from a 40-Year Cohort Study at a Reference Center in Southern Brazil"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3754-473X","authenticated-orcid":false,"given":"Elza Maria Hartmann","family":"Uberti","sequence":"first","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9563-000X","authenticated-orcid":false,"given":"Lidia Rosi de Freitas","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Bernardes","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Department of Obstetrics and Gynecology, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Silveira","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Guilherme \u00c1lvaro Hospital, Santos 11045-904, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9927-3246","authenticated-orcid":false,"given":"Cassiano Burman","family":"Patias","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Department of Radiology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90020-090, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo dos","family":"Santos Filho","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Department of Obstetrics and Gynecology, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosilene Jara","family":"Reis","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Department of Obstetrics and Gynecology, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josenel Maria Barcelos","family":"Copetti","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Department of Pathology, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, RS, Brazil"},{"name":"Department of Pathology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90020-090, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Pio","family":"Furtado","sequence":"additional","affiliation":[{"name":"Gestational Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90035-074, RS, Brazil"},{"name":"Santa Rita Hospital, Irmandade Santa Casa de Miseric\u00f3rdia de Porto Alegre, Porto Alegre 90050-170, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ijgo.70275","article-title":"Diagnosis and management of gestational trophoblastic disease: 2025 update","volume":"171","author":"Ngan","year":"2025","journal-title":"Int. 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