{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:49:04Z","timestamp":1782244144246,"version":"3.54.5"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Aim: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm with few reported mandibular cases. This review aims to describe the clinical characteristics, surgical management and outcomes of 13 mandibular IMT cases, and to introduce the Jaw in a Day (JIAD) approach as a novel surgical option. Methods: PubMed, Web of Science and Embase were searched systematically. From an initial pool of 261 articles, 13 studies met the inclusion criteria and were reviewed. Results: Thirteen mandibular IMT cases were identified in the literature. A new case is also presented: a 15-year-old female treated with surgical excision using the JIAD approach. At 12-month follow-up, oral function was restored with no disease recurrence. Discussion: Mandibular IMT is exceedingly rare. The JIAD approach offers immediate reconstruction with satisfactory functional outcomes, as supported by both the current case and the reviewed literature. Conclusions: The JIAD surgical approach may represent an effective management strategy for mandibular IMT. Further cases are needed to validate this approach and establish standardized treatment protocols.<\/jats:p>","DOI":"10.3390\/curroncol33070375","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:35:05Z","timestamp":1782239705000},"page":"375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mandibular Inflammatory Myofibroblastic Tumors: A Literature Review with a New Case Presentation"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6342-6567","authenticated-orcid":false,"given":"Cristina","family":"Benites","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6268-9687","authenticated-orcid":false,"given":"Kirollos","family":"Armosh","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1128-9204","authenticated-orcid":false,"given":"Edgar D.","family":"Uribe Sanchez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Ruddocks","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA"},{"name":"University of Florida Cancer Center, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Dziegielewski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Florida, Gainesville, FL 32611, USA"},{"name":"University of Florida Cancer Center, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/PAT.0000000000000050","article-title":"WHO classification of soft tissue tumours: An update based on the 2013 (4th) edition","volume":"46","author":"Jo","year":"2014","journal-title":"Pathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.sdentj.2016.10.001","article-title":"A rare case of inflammatory myofibroblastic tumor of the mandible mimicking a malignant tumor","volume":"29","author":"AlKindi","year":"2017","journal-title":"Saudi Dent. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jobcr.2017.09.005","article-title":"Inflammatory myofibroblastic tumour: A case report and a clinical update","volume":"7","author":"Andrade","year":"2017","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1097\/PRS.0b013e31828bd8d0","article-title":"Jaw in a day: Total maxillofacial reconstruction using digital technology","volume":"131","author":"Levine","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Choi, J.H. (2025). Inflammatory Myofibroblastic Tumor: An Updated Review. Cancers, 17.","DOI":"10.3390\/cancers17081327"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1148\/radiographics.19.5.g99se021107","article-title":"Cysts and cystic lesions of the mandible: Clinical and radiologic-histopathologic review","volume":"19","author":"Scholl","year":"1999","journal-title":"Radiographics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.joen.2015.09.006","article-title":"Inflammatory Myofibroblastic Tumor Mimicking Apical Periodontitis","volume":"41","author":"Adachi","year":"2015","journal-title":"J. Endod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2050313X221091670","DOI":"10.1177\/2050313X221091670","article-title":"Intraosseous inflammatory pseudotumor of the maxilla: A case report","volume":"10","author":"Odeh","year":"2022","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1284.e1","DOI":"10.1016\/j.joms.2016.01.047","article-title":"Fibula Jaw in a Day: State of the Art in Maxillofacial Reconstruction","volume":"74","author":"Qaisi","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"891","DOI":"10.14219\/jada.archive.1974.0517","article-title":"A large dental granuloma (inflammatory pseudotumor) with unusual features: Report of case","volume":"89","author":"Zegarelli","year":"1974","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0030-4220(93)90253-Z","article-title":"Intraoral inflammatory pseudotumor","volume":"76","author":"Earl","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0030-4220(93)90263-4","article-title":"Inflammatory pseudotumor in the submandibular region. Clinicopathologic study and review of the literature","volume":"76","author":"Inui","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/j.1600-0714.1998.tb01921.x","article-title":"Inflammatory pseudotumor in the mandibular retromolar region","volume":"27","author":"Ide","year":"1998","journal-title":"J. Oral Pathol. Med."},{"key":"ref_14","first-page":"28","article-title":"Myofibroblastic tumor of the oral cavity. A rare clinical entity","volume":"70","author":"Fang","year":"2004","journal-title":"N. Y. State Dent. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.tripleo.2004.11.023","article-title":"Oral inflammatory myofibroblastic tumor demonstrating ALK, p53, MDM2, CDK4, pRb, and Ki-67 immunoreactivity in an elderly patient","volume":"99","author":"Brooks","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1097\/SCS.0b013e318188a2e9","article-title":"Inflammatory Pseudotumor in the Mandible","volume":"19","author":"Oh","year":"2008","journal-title":"J. Craniofac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00795-009-0483-6","article-title":"A successfully treated inflammatory myofibroblastic tumor of the mandible with long-term follow-up and review of the literature","volume":"43","author":"Satomi","year":"2010","journal-title":"Med. Mol. Morphol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13000-016-0586-z","article-title":"Intraosseous inflammatory myofibroblastic tumor of the mandible with a novel ATIC-ALK fusion mutation: A case report","volume":"11","author":"Tateishi","year":"2016","journal-title":"Diagn. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/jomfp.JOMFP_122_15","article-title":"Inflammatory myofibroblastic tumor of mandible: A rare case report and review of literature","volume":"21","author":"Korlepara","year":"2017","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_20","first-page":"383","article-title":"Intraosseous Inflammatory Myofibroblastic Tumor of the Posterior Mandible: A Rare Case with Immunohistochemical Interpretation","volume":"26","author":"Tripathi","year":"2025","journal-title":"J. Dent."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/jjco\/hyad074","article-title":"Inflammatory myofibroblastic tumors: Recent progress and future of targeted therapy","volume":"53","author":"Nakano","year":"2023","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/RCT.0000000000000444","article-title":"Radiologic and Clinicopathologic Findings of Inflammatory Myofibroblastic Tumor","volume":"41","author":"Tan","year":"2017","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3892\/ol.2015.3168","article-title":"A case report of an inflammatory myofibroblastic tumor of the neck: A focus on the computed tomography and magnetic resonance imaging findings","volume":"10","author":"Cheng","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00256-011-1263-7","article-title":"Soft-tissue inflammatory myofibroblastic tumors (IMTs) of the limbs: Potential and limits of diagnostic imaging","volume":"41","author":"Masciocchi","year":"2012","journal-title":"Skelet. Radiol."},{"key":"ref_25","unstructured":"National Comprehensive Cancer Network (NCCN) (2026, May 01). NCCN Clinical Practice Guidelines in Oncology: Pediatric Soft Tissue Sarcoma, Version 1. Available online: https:\/\/www.nccn.org\/professionals\/physiciangls\/pdf\/pedsts.pdf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/RLU.0b013e3182952caa","article-title":"Inflammatory myofibroblastic tumor: FDG PET\/CT findings with pathologic correlation","volume":"39","author":"Dong","year":"2014","journal-title":"Clin. Nucl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Man, X., Dong, C., Dong, A., and Song, X. (2026). FDG PET\/CT in a Case of Inflammatory Myofibroblastic Tumor of the Bladder. Clin. Nucl. Med.","DOI":"10.1097\/RLU.0000000000006381"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.crad.2013.12.018","article-title":"Inflammatory myofibroblastic tumours of the liver: Gadoxetic acid-enhanced and diffusion-weighted MRI findings with 18F-FDG PET\/CT and clinical significance of regression on follow-up","volume":"69","author":"Kang","year":"2014","journal-title":"Clin. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00428-018-2350-0","article-title":"Misses and near misses in diagnosing nodular fasciitis and morphologically related reactive myofibroblastic proliferations: Experience of a referral center with emphasis on frequency of USP6 gene rearrangements","volume":"473","author":"Erber","year":"2018","journal-title":"Virchows Arch."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/his.13011","article-title":"USP6 gene rearrangement in nodular fasciitis and histological mimics","volume":"69","author":"Shin","year":"2016","journal-title":"Histopathology"},{"key":"ref_31","first-page":"e69995","article-title":"An Examination of the Diagnostic Utility of Ubiquitin-Specific Peptidase 6 (USP6) Rearrangement in Differentiating Nodular Fasciitis From Inflammatory Myofibroblastic Tumor: A Case Report","volume":"16","author":"Coleman","year":"2024","journal-title":"Cureus"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1097\/00000478-200111000-00003","article-title":"Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: A comparative immunohistochemical study","volume":"25","author":"Cook","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/01.MP.0000026615.04130.1F","article-title":"Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: A study of 135 cases","volume":"15","author":"Cessna","year":"2002","journal-title":"Mod. Pathol."},{"key":"ref_34","unstructured":"National Comprehensive Cancer Network (NCCN) (2026, May 01). NCCN Clinical Practice Guidelines in Oncology: Soft Tissue Sarcoma, Version 2. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/sarcoma.pdf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5125\/jkaoms.2023.49.2.96","article-title":"Oral spindle cell\/sclerosing rhabdomyosarcoma on mandible with anaplastic lymphoma kinase expression mimicking inflammatory myofibroblastic tumor","volume":"49","author":"Lee","year":"2023","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100271","DOI":"10.1016\/j.modpat.2023.100271","article-title":"Fusion-driven Spindle Cell Rhabdomyosarcomas of Bone and Soft Tissue: A Clinicopathologic and Molecular Genetic Study of 25 Cases","volume":"36","author":"Dehner","year":"2023","journal-title":"Mod. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/his.13649","article-title":"Spindle cell rhabdomyosarcoma of bone with FUS-TFCP2 fusion: Confirmation of a very recently described rhabdomyosarcoma subtype","volume":"73","author":"Dashti","year":"2018","journal-title":"Histopathology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/gcc.23145","article-title":"Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma\u2014Diagnostic challenge and report of two cases","volume":"62","author":"Liang","year":"2023","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tripleo.2004.03.026","article-title":"Aggressive fibromatosis involving the mandible\u2014Case report and review of the literature","volume":"99","author":"Seper","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.mayocp.2017.02.012","article-title":"Biology and Treatment of Aggressive Fibromatosis or Desmoid Tumor","volume":"92","author":"Skubitz","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/PAS.0000000000001167","article-title":"Morphologic Overlap Between Inflammatory Myofibroblastic Tumor and IgG4-related Disease: Lessons From Next-generation Sequencing","volume":"43","author":"Taylor","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1097\/PAS.0b013e3181a5a207","article-title":"Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: A comparative clinicopathologic study","volume":"33","author":"Yamamoto","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/modpathol.2010.226","article-title":"IgG4 plasma cells in inflammatory myofibroblastic tumor: Inflammatory marker or pathogenic link?","volume":"24","author":"Saab","year":"2011","journal-title":"Mod. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/PAI.0000000000000252","article-title":"A Comparative Study of Inflammatory Myofibroblastic Tumors and Tumefactive IgG4-related Inflammatory Lesions: The Relevance of IgG4 Plasma Cells","volume":"24","author":"Chougule","year":"2016","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13000-020-00966-4","article-title":"ALK-1-positive inflammatory myofibroblastic tumor of the thyroid complicated by Hashimoto\u2019s thyroiditis: Report of a rare case and a literature review","volume":"15","author":"Li","year":"2020","journal-title":"Diagn. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.joms.2021.11.017","article-title":"A Rare Presentation of Intraosseous Sarcoidosis of the Mandible Presenting as Peri-Implantitis: A Case Report and Literature Review","volume":"80","author":"Cheema","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1164\/rccm.202002-0251ST","article-title":"Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline","volume":"201","author":"Crouser","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jaber, M., Abouseif, N., Abdelmagied, M., and El-Ameen, E.M. (2025). Clinical and Demographic Characteristics of Oral Sarcoidosis: A Systematic Review of Case Reports and Case Series. J. Clin. Med., 14.","DOI":"10.3390\/jcm14197006"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/dc.21444","article-title":"Cytology of fine-needle aspiration of inflammatory myofibroblastic tumor","volume":"39","author":"Stoll","year":"2011","journal-title":"Diagn. Cytopathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/dc.20765","article-title":"Fine-needle aspiration cytology of soft tissue lesions: Diagnostic challenges","volume":"35","author":"Domanski","year":"2007","journal-title":"Diagn. Cytopathol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/cncr.21154","article-title":"Core-needle biopsy performed by the cytopathologist: A technique to complement fine-needle aspiration of soft tissue and bone lesions","volume":"105","author":"Domanski","year":"2005","journal-title":"Cancer"},{"key":"ref_52","first-page":"933","article-title":"Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies: Guideline From the College of American Pathologists","volume":"145","author":"Dacic","year":"2020","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/dc.23005","article-title":"Diagnostic accuracy and clinical utility of biopsy in musculoskeletal lesions: A comparison of fine-needle aspiration, core, and open biopsy techniques","volume":"42","author":"Layfield","year":"2014","journal-title":"Diagn. Cytopathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"108388","DOI":"10.1016\/j.ejso.2024.108388","article-title":"Treatment and outcomes in pediatric inflammatory myofibroblastic tumors\u2014A systematic review of published studies","volume":"50","author":"Raitio","year":"2024","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/ijc.34132","article-title":"Inflammatory myofibroblastic tumor: A multi-institutional study from the Pediatric Surgical Oncology Research Collaborative","volume":"151","author":"Rich","year":"2022","journal-title":"Int. J. Cancer"},{"key":"ref_56","unstructured":"Rich, B.S., Fishbein, J., Engstrom, B., Lautz, T., Rubalcava, N.S., Kartal, T., Newman, E., Dasgupta, R., and Glick, R.D. (2021, January 4\u20138). Inflammatory Myofibroblastic Tumor: A Multi-Institutional Study from the Pediatric Surgical Oncology Research Collaborative. Proceedings of the 2021 ASCO Annual Meeting, Virtual. Available online: https:\/\/www.asco.org\/abstracts-presentations\/195631."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.oraloncology.2011.09.004","article-title":"Head and neck inflammatory myofibroblastic tumor (IMT): Evaluation of clinicopathologic and prognostic features","volume":"48","author":"Ong","year":"2012","journal-title":"Oral Oncol."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/7\/375\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:30:24Z","timestamp":1782243024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/7\/375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":57,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["curroncol33070375"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33070375","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}