{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:48:49Z","timestamp":1782719329593,"version":"3.54.5"},"reference-count":24,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS Core-to-Core Program","doi-asserted-by":"publisher","award":["JPJSCCA20240005"],"award-info":[{"award-number":["JPJSCCA20240005"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["JP23K27548"],"award-info":[{"award-number":["JP23K27548"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Background\/Objectives: Accurate preoperative assessment of peritoneal dissemination is essential in ovarian cancer because it influences surgical strategy and the achievement of complete gross resection. However, [18F]FDG-PET may be limited in detecting lesions with low glycolytic activity and in differentiating malignancy from inflammatory changes. This case series evaluated the clinical relevance of [18F]FAPI-74 PET\/CT for preoperative assessment of peritoneal dissemination in ovarian cancer. Methods: Four patients underwent [18F]FAPI-74 PET\/CT as part of preoperative evaluation, with comparison to [18F]FDG-PET\/CT when available. Imaging findings were correlated with intraoperative observations and histopathological results, including immunohistochemical assessment of fibroblast activation protein and \u03b1-smooth muscle actin. Results: FAPI-PET detected peritoneal dissemination not identified by FDG-PET in several cases, including occult metastasis confirmed histologically and additional lesions after neoadjuvant chemotherapy. FAPI-avid lesions showed stromal activation on immunohistochemistry, supporting the biological basis of FAPI uptake. In one case, additional FAPI uptake may have been partly influenced by inflammatory changes associated with bloody ascites. Conclusions: FAPI-PET may provide complementary information by visualizing stromal components of ovarian cancer and may support preoperative mapping of peritoneal dissemination, although interpretation should consider inflammatory conditions.<\/jats:p>","DOI":"10.3390\/curroncol33070389","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:49:33Z","timestamp":1782712173000},"page":"389","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["[18F]FAPI-74 PET for Preoperative Assessment of Peritoneal Dissemination in Ovarian Cancer: A Case Series with Surgical and Histopathological Correlation"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-3182","authenticated-orcid":false,"given":"Aasa","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-2395","authenticated-orcid":false,"given":"Tadashi","family":"Watabe","sequence":"additional","affiliation":[{"name":"Laboratory for Theranostics, Division of Clinical Translation, Institute for Radiation Sciences, The University of Osaka, 1-10, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik L.","family":"Giesel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, Moorenstra\u00dfe 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadahiro","family":"Naka","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The University of Osaka, 2-15, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, The University of Osaka, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2081-3020","authenticated-orcid":false,"given":"Kayako","family":"Isohashi","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Tatsumi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Juntendo University Graduate School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-7327","authenticated-orcid":false,"given":"Noriyuki","family":"Tomiyama","sequence":"additional","affiliation":[{"name":"Department of Radiology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2910-7720","authenticated-orcid":false,"given":"Yasuto","family":"Kinose","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"},{"name":"Department of Obstetrics and Gynecology, Sakai City Medical Center, 1-1-1, Ebaraji-cho, Nishi-ku, Sakai City 593-8304, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Iwamiya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-9994","authenticated-orcid":false,"given":"Shinya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"},{"name":"Department of Obstetrics and Gynecology, Ehime University Graduate School of Medicine, Shitsukawa, Toon 791-0204, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4046-7572","authenticated-orcid":false,"given":"Michiko","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The University of Osaka Graduate School of Medicine, 2-2, Yamadaoka, Suita City 565-0871, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00259-017-3638-z","article-title":"An update on the role of PET\/CT and PET\/MRI in ovarian cancer","volume":"44","author":"Khiewvan","year":"2017","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.7150\/thno.40599","article-title":"FDG uptake in cancer: A continuing debate","volume":"10","author":"Peppicelli","year":"2020","journal-title":"Theranostics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/RLU.0000000000003962","article-title":"Potential and most relevant applications of total body PET\/CT imaging","volume":"47","author":"Alavi","year":"2022","journal-title":"Clin. Nucl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.2967\/jnumed.123.265486","article-title":"Initial evaluation of [18F]FAPI-74 PET for various histopathologically confirmed cancers and benign lesions","volume":"64","author":"Watabe","year":"2023","journal-title":"J. Nucl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41571-024-00881-3","article-title":"Global epidemiology of epithelial ovarian cancer","volume":"21","author":"Webb","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"108523","DOI":"10.1016\/j.ejso.2024.108523","article-title":"The paradigm shift in advanced ovarian cancer: Outcomes of extensive primary cytoreductive surgery. A single-center retrospective analysis","volume":"50","author":"Bianchi","year":"2024","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.3802\/jgo.2023.34.e84","article-title":"An overview of the current debate between using minimally invasive surgery versus laparotomy for interval cytoreductive surgery in epithelial ovarian cancer","volume":"34","author":"Finch","year":"2023","journal-title":"J. Gynecol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e2446325","DOI":"10.1001\/jamanetworkopen.2024.46325","article-title":"Laparoscopic cytoreduction after neoadjuvant chemotherapy in high-grade epithelial ovarian cancer: A LANCE randomized clinical trial","volume":"7","author":"Melamed","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hayek, J., An, A., Wolf, J., Lamiman, K., Kim, M., Knochenhauer, H., Goncalves, N., and Alagkiozidis, I. (2025). Overall survival following interval complete gross resection of advanced ovarian cancer via laparoscopy versus open surgery: An analysis of the National Cancer Database. J. Clin. Med., 14.","DOI":"10.3390\/jcm14041164"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ygyno.2025.04.518","article-title":"Disparities in facility-level adoption of minimally invasive interval debulking surgery for advanced ovarian cancer","volume":"197","author":"Wilke","year":"2025","journal-title":"Gynecol. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41571-021-00546-5","article-title":"Clinical and therapeutic relevance of cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s43018-022-00411-z","article-title":"Cancer-associated fibroblasts in the single-cell era","volume":"3","author":"Lavie","year":"2022","journal-title":"Nat. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, M., Chen, Z., Wang, Y., Zhao, H., and Du, Y. (2022). The role of cancer-associated fibroblasts in ovarian cancer. Cancers, 14.","DOI":"10.3390\/cancers14112637"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e220749","DOI":"10.1148\/radiol.220749","article-title":"FAPI PET: Fibroblast activation protein inhibitor use in oncologic and nononcologic disease","volume":"306","author":"Mori","year":"2023","journal-title":"Radiology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Guglielmo, P., Alongi, P., Baratto, L., Abenavoli, E., Buschiazzo, A., Celesti, G., Conte, M., Filice, R., Gorica, J., and Jonghi-Lavarini, L. (2023). Head-to-head comparison of FDG and radiolabeled FAPI PET: A systematic review of the literature. Life, 13.","DOI":"10.3390\/life13091821"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1007\/s00259-023-06369-z","article-title":"[68Ga]Ga-FAPI-04 PET\/CT in the evaluation of epithelial ovarian cancer: Comparison with [18F]F-FDG PET\/CT","volume":"50","author":"Chen","year":"2023","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1007\/s00259-025-07277-0","article-title":"Head-to-head comparison of fibroblast activation protein inhibitors (FAPI) radiopharmaceuticals and [18F]FDG in gynaecological malignancies: Systematic literature review and meta-analysis","volume":"52","author":"Florit","year":"2025","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2417775","DOI":"10.1001\/jamanetworkopen.2024.17775","article-title":"Primary cytoreduction and survival for patients with less-common epithelial ovarian cancer","volume":"7","author":"Matsuo","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1007\/s00259-020-04769-z","article-title":"Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET\/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer","volume":"47","author":"Chen","year":"2020","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Liu, X., Liu, H., Gao, C., and Zeng, W. (2023). Comparison of 68Ga-FAPI and 18F-FDG PET\/CT for the diagnosis of primary and metastatic lesions in abdominal and pelvic malignancies: A systematic review and meta-analysis. Front. Oncol., 12.","DOI":"10.3389\/fonc.2023.1093861"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2967\/jnumed.119.227967","article-title":"68Ga-FAPI PET\/CT: Tracer uptake in 28 different kinds of cancer","volume":"60","author":"Kratochwil","year":"2019","journal-title":"J. Nucl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s12276-023-01013-0","article-title":"Cancer-associated fibroblasts: From basic science to anticancer therapy","volume":"55","author":"Yang","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41586-025-09303-5","article-title":"NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity","volume":"645","author":"Heide","year":"2025","journal-title":"Nature"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/7\/389\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T07:35:19Z","timestamp":1782718519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/7\/389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["curroncol33070389"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33070389","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}