{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:28:34Z","timestamp":1785421714431,"version":"3.56.0"},"reference-count":28,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council, Singapore","doi-asserted-by":"crossref","award":["NMRC\/TA\/0064\/2018"],"award-info":[{"award-number":["NMRC\/TA\/0064\/2018"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"crossref"}]},{"award":["NMRC\/TA\/0064\/2018"],"award-info":[{"award-number":["NMRC\/TA\/0064\/2018"]}],"id":[{"id":"https:\/\/ror.org\/04x3cxs03","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Oncology"],"abstract":"<jats:p>Focal therapy (FT) for localized prostate cancer induces architectural changes that complicate post-treatment multiparametric magnetic resonance imaging (mpMRI) surveillance. The Prostate Imaging after Focal Ablation (PI-FAB) system was developed to standardize the evaluation of in-field recurrence on mpMRI. This study assessed the diagnostic performance and inter-reader agreement of PI-FAB following focal cryoablation for localized prostate cancer. In this retrospective study (October 2019 to January 2024), 85 patients (140 lesion sites) underwent post-FT mpMRI and biopsy. Two radiologists (11 and 4 years of experience) independently scored mpMRIs using the three-point PI-FAB scale. Metrics included sensitivity, specificity, PPV, NPV, and accuracy. Inter-reader agreement was measured via quadratic weighted Cohen\u2019s kappa (\u03ba). Reader 1 (more experienced) demonstrated 83.9% sensitivity, 84.4% specificity, 60.5% PPV, and 94.8% NPV. Reader 2 demonstrated 71.4% sensitivity, 87.5% specificity, 58.8% PPV, and 92.5% NPV. Both achieved 84.3% accuracy. Inter-reader agreement was moderate (\u03ba = 0.60). PI-FAB provides good diagnostic performance for detecting in-field recurrence after cryoablation. While reader experience may impact sensitivity, moderate agreement across experience levels supports PI-FAB\u2019s validity and potential clinical utility in standardizing post-FT surveillance.<\/jats:p>","DOI":"10.3390\/curroncol33070417","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:05:31Z","timestamp":1783929931000},"page":"417","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Diagnostic Performance and Inter-Reader Agreement of Prostate Imaging After Focal Ablation (PI-FAB) on Post-Focal Therapy (FT) Magnetic Resonance Imaging (MRI)"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5660-6656","authenticated-orcid":false,"given":"Guanqi","family":"Hang","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic and Abdominal Radiology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2773-2581","authenticated-orcid":false,"given":"Zhuyi Rebekah","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Abdominal Radiology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lois","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Abdominal Radiology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-4330","authenticated-orcid":false,"given":"Jyothirmayi","family":"Velaga","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, St. Vincent\u2019s Hospital, Sydney 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua Thun","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby Xuan Lin","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Guang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-0817","authenticated-orcid":false,"given":"Nye Thane","family":"Ngo","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Shyi P.","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-9447","authenticated-orcid":false,"given":"Li Yan","family":"Khor","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1648-1473","authenticated-orcid":false,"given":"Melvin Lee Kiang","family":"Chua","sequence":"additional","affiliation":[{"name":"Divisions of Radiation Oncology and Medical Sciences, National Cancer Centre Singapore, Singapore 168583, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kae Jack","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Urology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-4281","authenticated-orcid":false,"given":"Yan Mee","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Abdominal Radiology, Singapore General Hospital, Singapore 169608, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1016\/j.juro.2008.08.003","article-title":"Optimal parameters for the destruction of prostate cancer using irreversible electroporation","volume":"180","author":"Rubinsky","year":"2008","journal-title":"J. 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