{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:49:23Z","timestamp":1786121363892,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project","award":["2025ZD01905004"],"award-info":[{"award-number":["2025ZD01905004"]}]},{"name":"Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project","award":["2026ZD01911605"],"award-info":[{"award-number":["2026ZD01911605"]}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"crossref","award":["2025A03J3908"],"award-info":[{"award-number":["2025A03J3908"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"crossref","award":["2025A03J3902"],"award-info":[{"award-number":["2025A03J3902"]}],"id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2025A03J3908"],"award-info":[{"award-number":["2025A03J3908"]}],"id":[{"id":"https:\/\/ror.org\/00zat6v61","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2025A03J3902"],"award-info":[{"award-number":["2025A03J3902"]}],"id":[{"id":"https:\/\/ror.org\/00zat6v61","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2311100"],"award-info":[{"award-number":["2024YFC2311100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Oncol.","Current Oncology"],"abstract":"<jats:p>Epstein\u2013Barr virus (EBV) contributes to human immunodeficiency virus (HIV)-associated diffuse large B-cell lymphoma (DLBCL) pathogenesis. We retrospectively analyzed clinical features and outcomes of EBV-positive (n = 32) and -negative (n = 71) cases. EBV status was determined using in situ hybridization. Immunological parameters, histological subtype, systemic B symptoms, plasma EBV DNA, and response to therapy were examined. Survival was compared using Kaplan\u2013Meier analysis. Factors associated with overall survival (OS) and progression-free survival (PFS) in EBV-positive patients were examined using Cox regression models. EBV-positive cases showed a higher proportion of non-germinal center B cell subtypes and B symptoms, higher circulating EBV viral loads, and lower CD4+ T-cell counts at diagnosis than EBV-negative cases. OS did not differ significantly within the full cohort but was shorter in EBV-positive cases with high International Prognostic Index scores or CD4+ T-cell counts \u2265 50 cells\/\u03bcL. Concurrent infections and elevated plasma EBV DNA levels remained associated with unfavorable survival outcomes. EBV-positivity in HIV-associated DLBCL is related to more aggressive clinical and immunological features and independently predicts poorer survival outcomes in high-risk subgroups. Plasma EBV DNA may reliably indicate EBV status and serve as a prognostic biomarker. Integrating these features into clinical decision-making may enhance risk stratification and inform individualized treatments.<\/jats:p>","DOI":"10.3390\/curroncol33080466","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:48:08Z","timestamp":1785948488000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Prognostic Analysis of EBV-Positive HIV-Associated Diffuse Large B-Cell Lymphoma in China: A Retrospective Single-Center Study"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9347-0825","authenticated-orcid":false,"given":"Lizhi","family":"Feng","sequence":"first","affiliation":[{"name":"Infectious Disease Center, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou 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Medical Research Institute of Infectious Diseases, Guangzhou 510440, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Infectious Disease Center, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou 510440, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Infectious Disease Center, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou 510440, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1757-1411","authenticated-orcid":false,"given":"Haisheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Key Laboratory of Clinical Pathogen Research for Infectious Diseases, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Key Laboratory of Clinical Pathogen Research for Infectious Diseases, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Tang","sequence":"additional","affiliation":[{"name":"Infectious Disease Center, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou 510440, China"},{"name":"Institute of Infectious Disease, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5711-8681","authenticated-orcid":false,"given":"Linghua","family":"Li","sequence":"additional","affiliation":[{"name":"Infectious Disease Center, Guangzhou Eighth People\u2019s Hospital, Guangzhou Medical University, Guangzhou 510440, China"},{"name":"Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou 510440, 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