{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:32:07Z","timestamp":1786527127008,"version":"build-2736575974"},"reference-count":24,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004319","name":"Shin-Kong Wu Ho-Su Memorial Hospital Research Foundation","doi-asserted-by":"publisher","award":["2025SKHADR011"],"award-info":[{"award-number":["2025SKHADR011"]}],"id":[{"id":"10.13039\/501100004319","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2025SKHADR011"],"award-info":[{"award-number":["2025SKHADR011"]}],"id":[{"id":"https:\/\/ror.org\/04x744g62","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Oncol.","Current Oncology"],"abstract":"<jats:p>Chronic kidney disease (CKD) may reduce physiologic reserve among patients with esophageal cancer, but evidence beyond postoperative cohorts is limited. Using the TriNetX Global Collaborative Network, we studied adults with esophageal cancer diagnosed during 2010\u20132023. CKD stages 3\u20135 were defined by diagnostic codes plus estimated glomerular filtration rate &lt; 60 mL\/min\/1.73 m2 within 6 months before or on the index date; dialysis-dependent patients were excluded. Non-CKD patients served as comparators. Prespecified outcomes from day 1 to up to 3 years included all-cause mortality, subsequent recorded metastatic diagnosis, pneumonia, sepsis, blood transfusion, and major adverse cardiovascular events. Propensity score matching produced 832 pairs. All-cause mortality was not significantly higher in the overall cohort with CKD stages 3\u20135 than in the non-CKD cohort (HR, 1.13; 95% CI, 0.98\u20131.31; p = 0.099), whereas CKD stages 4\u20135 were associated with higher mortality in the stage-specific analysis (HR, 1.46; 95% CI, 1.03\u20132.06; p = 0.031). CKD stages 3\u20135 were also associated with higher risks of blood transfusion (HR, 1.45; 95% CI, 1.04\u20132.01; p = 0.025) and MACEs (HR, 1.22; 95% CI, 1.02\u20131.47; p = 0.027), and with a lower risk of subsequent recorded metastatic diagnosis (HR, 0.80; 95% CI, 0.65\u20130.99; p = 0.036). These findings suggest that the associations of CKD with post-diagnostic outcomes varied by outcome type, with higher mortality observed in the separate CKD stages 4\u20135 analysis.<\/jats:p>","DOI":"10.3390\/curroncol33080474","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:57:26Z","timestamp":1786521446000},"page":"474","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Chronic Kidney Disease Stages 3\u20135 on Mortality and Morbidity Outcomes in Patients with Esophageal Cancer: A Propensity-Score-Matched Cohort Study"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8100-2914","authenticated-orcid":false,"given":"Tsai-Lung","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4048-4444","authenticated-orcid":false,"given":"Cheng-Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan"},{"name":"Department of General Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Kuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan"},{"name":"Division of Digital Informatics Management, Department of Digital Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111045, Taiwan"},{"name":"School of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/S0140-6736(24)02226-8","article-title":"Oesophageal Cancer","volume":"404","author":"Yang","year":"2024","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.athoracsur.2024.04.034","article-title":"Multimodal Treatment of Resectable Esophageal Cancer","volume":"119","author":"Waters","year":"2025","journal-title":"Ann. 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