{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:06Z","timestamp":1789016826016,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Oncol.","Current Oncology"],"abstract":"<jats:p>Background: Prostate cancer substantially affects patients\u2019 quality of life (QoL). However, whether distinct QoL profiles exist among patients remains unclear. Objective: This study aimed to identify latent QoL profiles among patients with prostate cancer and explore factors associated with profile membership. Methods: A cross-sectional study included 200 patients with prostate cancer recruited from a tertiary hospital in China between May and December 2024. QoL was assessed using the Functional Assessment of Cancer Therapy\u2013Prostate (FACT-P). Latent profile analysis was performed using Mplus 8.3, and the optimal model was selected according to information criteria, entropy, and likelihood ratio tests. Multivariable logistic regression was used to examine factors associated with profile membership. Results: LPA identified two distinct subgroups: low QoL (32.5%) and high QoL (67.5%). Medium and heavy economic burden significantly increased odds of low QoL (OR = 4.13, 95% CI: 1.13\u201315.02, p = 0.032; OR = 11.12, 95% CI:1.55\u201379.86, p = 0.017). Urinary continence markedly reduced odds of low QoL (OR = 0.08, 95% CI: 0.02\u20130.25, p &lt; 0.001). Longer diagnosis-to-treatment intervals were associated with membership in the low-QoL profile (1\u20133 months: OR = 2.99, 95% CI: 1.26\u20137.08, p = 0.013; &gt;3 months: OR = 3.36, 95% CI: 1.02\u201311.07, p = 0.046). Conclusions: This study identified two QoL profiles among patients with prostate cancer. The findings suggest that person-centered QoL assessment may facilitate early identification of patients with greater supportive care needs and contribute to more individualized survivorship care.<\/jats:p>","DOI":"10.3390\/curroncol33090532","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:39:47Z","timestamp":1788363587000},"page":"532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identifying Distinct Quality-of-Life Profiles in Prostate Cancer Patients: A Latent Profile Approach"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0216-0801","authenticated-orcid":false,"given":"Linan","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Nursing, Wenzhou Medical University, Wenzhou 325035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s11764-020-00869-9","article-title":"Quality of life in \u201cchronic\u201d cancer survivors: A meta-analysis","volume":"14","author":"Firkins","year":"2020","journal-title":"J. Cancer Surviv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.jgo.2020.12.009","article-title":"Prevalence and predictors of depressive symptoms in older adults with cancer","volume":"12","author":"Parajuli","year":"2021","journal-title":"J. Geriatr. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sekhoacha, M., Riet, K., Motloung, P., Gumenku, L., Adegoke, A., and Mashele, S. (2022). Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches. Molecules, 27.","DOI":"10.3390\/molecules27175730"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.21037\/apm-21-1229","article-title":"Symptom trajectories and influencing factors of prostate cancer following radical prostatectomy in Chinese patients","volume":"10","author":"Zeng","year":"2021","journal-title":"Ann. Palliat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151369","DOI":"10.1016\/j.soncn.2022.151369","article-title":"An Exploration of Family Caregivers\u2019 Health Care Needs When Caring for Patients With Cancer in the Resource-Challenged Context of West Java, Indonesia","volume":"39","author":"Purba","year":"2023","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejca.2022.10.026","article-title":"Content validity of the EORTC quality of life questionnaire QLQ-C30 for use in cancer","volume":"178","author":"Cocks","year":"2023","journal-title":"Eur. J. Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0885-3924(96)00274-6","article-title":"Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system","volume":"13","author":"Yellen","year":"1997","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2217\/cer.14.41","article-title":"Development, characteristics and validity of the EORTC QLQ-PR25 and the FACT-P for assessment of quality of life in prostate cancer patients","volume":"3","author":"Chu","year":"2014","journal-title":"J. Comp. Eff. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/pon.1817","article-title":"Efficient assessment of the most important symptoms in advanced prostate cancer: The NCCN\/FACT-P Symptom Index","volume":"20","author":"Victorson","year":"2011","journal-title":"Psychooncology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"dju132","DOI":"10.1093\/jnci\/dju132","article-title":"Recommended patient-reported core set of symptoms to measure in prostate cancer treatment trials","volume":"106","author":"Chen","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Peters, E., Schulz, L.M., and Reuss-Borst, M. (2016). Quality of life after cancer-How the extent of impairment is influenced by patient characteristics. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2822-z"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1007\/s11255-025-04510-5","article-title":"Patient satisfaction and decision regret in patients undergoing radical prostatectomy: A multicenter analysis","volume":"57","author":"Guercio","year":"2025","journal-title":"Int. Urol. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s11912-025-01660-8","article-title":"Patterns of Care and Treatment Outcomes Among Men Diagnosed with Prostate Cancer from Culturally and Linguistically Diverse Backgrounds: A Scoping Review","volume":"27","author":"Tamirat","year":"2025","journal-title":"Curr. Oncol. Rep."},{"key":"ref_14","first-page":"816","article-title":"Correction to: Effectiveness of dyadic interventions on family function, caregiver burden and symptom distress for cancer patients and family caregivers: A meta-analysis of randomized controlled trials","volume":"34","author":"Li","year":"2026","journal-title":"Support. Care Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"103002","DOI":"10.1016\/j.ejon.2025.103002","article-title":"Informing the development of a nurse-led survivorship intervention for men with prostate cancer treated with androgen deprivation therapy: A qualitative exploratory study","volume":"79","author":"Sara","year":"2025","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.33546\/bnj.1927","article-title":"Establishing appropriate sample size for developing and validating a questionnaire in nursing research","volume":"7","author":"Gunawan","year":"2021","journal-title":"Belitung Nurs. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/10705510701575396","article-title":"Deciding on the Number of Classes in Latent Class Analysis and Growth Mixture Modeling: A Monte Carlo Simulation Study","volume":"14","author":"Nylund","year":"2007","journal-title":"Struct. Equ. Model. A Multidiscip. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1080\/10705511.2013.824781","article-title":"Statistical Power to Detect the Correct Number of Classes in Latent Profile Analysis","volume":"20","author":"Tein","year":"2013","journal-title":"Struct. Equ. Model."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0090-4295(97)00459-7","article-title":"Measuring quality of life in men with prostate cancer using the functional assessment of cancer therapy-prostate instrument","volume":"50","author":"Esper","year":"1997","journal-title":"Urology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.32614\/RJ-2016-021","article-title":"mclust 5: Clustering, Classification and Density Estimation Using Gaussian Finite Mixture Models","volume":"8","author":"Scrucca","year":"2016","journal-title":"R J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.3390\/curroncol31090366","article-title":"Quality of Life Determinants in Patients with Metastatic Prostate Cancer: Insights from a Cross-Sectional Questionnaire-Based Study","volume":"31","author":"Mittal","year":"2024","journal-title":"Curr. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s11136-015-0993-8","article-title":"Psychometric properties of Functional Assessment of Cancer Therapy-Prostate (FACT-P) in Chinese patients with prostate cancer","volume":"24","author":"Wong","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhao, X., Liu, S., Zou, Z., and Liang, C. (2025). Global, regional, and national prevalence of prostate cancer from 1990 to 2021: A trend and health inequality analyses. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1595159"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hiatt, R.A., Xun, W., Santiago-Rodriguez, E.J., Pikhartova, J., and Shelton, N. (2025). Socio-economic position, area-level deprivation and gradients in cancer incidence: England and Wales, 1971\u20132016. BMC Public Health, 25.","DOI":"10.1186\/s12889-025-21875-5"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41585-024-00948-x","article-title":"Racial disparities in prostate cancer in the UK and the USA: Similarities, differences and steps forwards","volume":"22","author":"Dee","year":"2025","journal-title":"Nat. Rev. Urol."},{"key":"ref_26","first-page":"3461","article-title":"Burden among partner caregivers of patients diagnosed with localized prostate cancer within 1 year after diagnosis: An economic perspective","volume":"21","author":"Li","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.21037\/tlcr-2025-599","article-title":"The impact of rurality, socioeconomic status, and health literacy on lung cancer screening uptake: A systematic review protocol","volume":"14","author":"Phulgirkar","year":"2025","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hatam, N., Askarian, M., Taherifard, E., Ahmadkhani, A., Golabi, F., Bordbar, S., and Taherifard, E. (2025). Exploring patient-centered care delivery in outpatient settings for older adults: A scoping review and recommendations for implementation in countries with low and middle income. BMC Geriatr., 25.","DOI":"10.1186\/s12877-025-06643-9"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101547","DOI":"10.1016\/j.ehb.2025.101547","article-title":"Impact of health insurance expansion on patients\u2019 financial burden and family well-being in South Korea","volume":"59","author":"Bae","year":"2025","journal-title":"Econ. Hum. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5334\/ijic.9054","article-title":"Community Cancer Champions\u2019 Project: Learning from the Design and Implementation of an Integrated Health and Voluntary and Community Sector (VCS) Asset-Based Community Development Project-A Case Study from Plymouth, England","volume":"25","author":"Stevenson","year":"2025","journal-title":"Int. J. Integr. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"151649","DOI":"10.1016\/j.soncn.2024.151649","article-title":"Innovative Cancer Follow-Up with Telehealth: A New Method for Oncology Nurses","volume":"40","author":"Donmez","year":"2024","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4103\/ijc.IJC_1009_19","article-title":"The economic burden of esophageal cancer in Iran","volume":"59","author":"Daroudi","year":"2022","journal-title":"Indian J. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhou, X., Bao, R., Guan, X., Li, W., Yang, C., Zhu, R., Li, H., and Wang, X. (2025). A pay-it-forward approach to improve feedback rate of HPV-based self-sampling in cervical cancer screening among women in ethnic minority regions of China: A randomized controlled trial protocol. Front. Psychiatry, 16.","DOI":"10.3389\/fpsyt.2025.1586076"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104612","DOI":"10.1016\/j.breast.2025.104612","article-title":"Improving equitable access to comprehensive care for people with advanced breast cancer: A global expert review and call-to-action for 2025\u20132035 (Goal 9)","volume":"84","author":"Eniu","year":"2025","journal-title":"Breast"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Shen, Y., Deng, J., Wu, S., Liu, L., Guan, H., and Cai, R. (2025). Financial Toxicity and Psychosocial Challenges of Chinese Parents in Pediatric Cancer Treatment: A Phenomenological Study. Cancer Nurs., Epub ahead of printing.","DOI":"10.1097\/NCC.0000000000001508"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/MPH.0000000000003085","article-title":"Exploration of Psychosocial Issues of Parents in Pediatric Oncology","volume":"47","author":"Jose","year":"2025","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_37","first-page":"1156","article-title":"Gaps in care, support, and research among diverse patients with early onset cancers","volume":"33","author":"Reedy","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jocn.12042","article-title":"Long-term urinary catheter users self-care practices and problems","volume":"22","author":"Wilde","year":"2013","journal-title":"J. Clin. Nurs."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/WON.0000000000000069","article-title":"Living with a long-term, indwelling urinary catheter: Catheter users\u2019 experience","volume":"41","author":"Fowler","year":"2014","journal-title":"J. Wound Ostomy Cont. Nurs."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Youssef, N., Shepherd, A., Best, C., Hagen, S., Mackay, W., Waddell, D., and El Sebaee, H. (2023). The Quality of Life of Patients Living with a Urinary Catheter and Its Associated Factors: A Cross-Sectional Study in Egypt. Healthcare, 11.","DOI":"10.3390\/healthcare11162266"},{"key":"ref_41","first-page":"409","article-title":"Factors influencing fear of cancer recurrence among prostate cancer patients: A systematic review and meta-analysis","volume":"33","author":"Qi","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1097\/JS9.0000000000003266","article-title":"Impact of the COVID-19 pandemic in 2020 on the diagnosis, treatment, and prognosis of major cancers","volume":"111","author":"Tang","year":"2025","journal-title":"Int. J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e425","DOI":"10.1097\/jnr.0000000000000713","article-title":"Immunotherapy Decision-Making Experiences of Patients with Cancer and Their Family Caregivers: A Qualitative Study","volume":"33","author":"Lee","year":"2025","journal-title":"J. Nurs. Res."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/9\/532\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:16:42Z","timestamp":1789013802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/9\/532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["curroncol33090532"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33090532","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}